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Sally Rose

Publications and source records attributed to Sally Rose.

8 recordsLinked to original sources
PubMed2005

A preliminary study of the metabolic stability of a series of benzoxazinone derivatives as potent neuropeptide Y5 antagonists.

The metabolic stability of benzoxazinone derivatives, a potent series of NPY Y5 antagonists, has been investigated. This study resulted in the identification of the structural moieties prone to metabolic transformations and which strongly influenced the in vitro half-life. This provides opportunities to optimize the structure of this new class of NPY Y5 antagonists.

Drug Evaluation, Preclinical↗
PubMed2005

High rates of chlamydia in patients referred for termination of pregnancy: treatment, contact tracing, and implications for screening.

AIMS: To determine the rate of chlamydia and other sexually transmitted infections (STIs), and to describe treatment and factors associated with chlamydia in patients presenting for a termination of pregnancy (TOP). METHODS: A retrospective audit of patients attending one of two TOP clinics from 1 February 2003. (Clinic A, n=500; Clinic B, n=501). Age, ethnicity, marital status, previous pregnancies, contraception, STIs, and treatment were recorded. RESULTS: Ten percent of patients tested positive for an STI. Chlamydia was most commonly detected, in 7.7% of all patients. Higher rates of chlamydia were observed at clinic B (10.2% vs 5.2%, p=0.005) and in under 25 year olds (11.2% vs 3.6%, p<0.001). Rates of chlamydia in Pacific women were 18.6%, in Maori 12.9%, in Asian 7.3% and 4.4% in New Zealand European women. All patients testing positive for chlamydia were treated prior to TOP but only 41% of partners were treated. Other infections detected included 18 cases of human papillomavirus (HPV), three cases of trichomoniasis, one case of gonorrhoea, and one case of syphilis. CONCLUSIONS: There is a high rate of chlamydia in women presenting for TOP, particularly in under 25 year olds, Pacific, and Maori women. There is an immediate need for policymakers to respond to this increasing burden of chlamydia by instigating targeted education, guidelines, and mandatory chlamydia screening and contact tracing for pregnant women.

Abortion, Induced↗
PubMed2004

Risk factors for type 2 diabetes in postmenopausal New Zealand women: a cross-sectional study.

AIM: To describe the diabetes risk profile of 3377 postmenopausal New Zealand women. METHODS: Participants took part in a face-to-face interview with a research nurse. Medical history, lifestyle information, height, weight, and random capillary blood glucose were recorded. Risk scores for type 2 diabetes were later calculated for each participant using a modified diabetes 'risk analysis' tool developed by the United States Diabetes Prevention Program (DPP). RESULTS: 157 women had diagnosed diabetes (4.4%) and were not therefore included in the risk analysis. Over half of the women (1843 of 3377) were at 'high risk' for the development of type 2 diabetes when assessed using the DPP diabetes risk analysis tool; 38.6% of participants were overweight, 25.6% were obese, 32.5% were physically inactive, 16.9% had a family history of diabetes, and 6.5% had random capillary blood glucose recordings of 7.5 mmol/L or greater. CONCLUSION: Risk factors for type 2 diabetes are prevalent in this group of postmenopausal New Zealand women. To appropriately target lifestyle modification programmes, these findings (in conjunction with recent evidence that lifestyle modification can reduce diabetes onset) highlight an urgent need to identify those women with risk factors before they develop type 2 diabetes.

Aged↗
PubMed2004

Rates of Chlamydia trachomatis testing and chlamydial infection in pregnant women.

AIMS: To determine the rate of Chlamydia trachomatis testing and chlamydial infection in pregnancy (by auditing a community medical laboratory database). METHODS: Data for women registered with a maternity care provider between 1999 and 2002 were matched with a community medical laboratory database for patients who met one of three criteria: tested for C. trachomatis, or had a first or second antenatal blood screen at that laboratory. The rate of C. trachomatis testing and of chlamydial infection was then calculated in this sample. RESULTS: The overall rate of C. trachomatis testing for 6614 matched deliveries was 37.5%, with 4.8% of those tests positive for chlamydial infection. The rate of testing differed significantly between age-bands (p<0.0001), and by ethnicity (p<0.0001). The rate of infection showed a significant effect of age (p<0.0001) and ethnicity (p<0.0001). Maori and Pacific women, and those under the age of 25 years, had the highest rates--both of testing and of C. trachomatis infection. CONCLUSIONS: There is a high rate of maternal C. trachomatis in under 25-year-olds, and in Maori and Pacific women, together with incomplete testing for the infection in pregnancy. This highlights the need to instigate routine testing for C. trachomatis in pregnancy--to reduce the significant, yet preventable, morbidity associated with chlamydia in both the mother and the neonate.

Adolescent↗
PubMed2003

Computational design strategies for combinatorial libraries.

Medicinal chemistry principles are being increasingly applied to the design of smaller, high purity, information-rich libraries. Recent computational advances in statistical methodology, the design of libraries to reduce ADMET problems, targeting protein families and revisiting natural products as sources of inspiration for scaffolds and reagents are all areas of progressive research.

Animals↗
PubMed2002

Statistical design and application to combinatorial chemistry.

Combinatorial chemistry has matured from its early production-belt image of synthesizing the maximum number of compounds in the minimum amount of time. It is now a discovery technology driven by good experimental design, with a focus on producing high numbers of quality drug-like compounds. Complex statistical and optimization algorithms are routinely applied to ensure that the library is designed with the best chance of achieving its goals, while also facilitating efficient synthesis.

Chemical Phenomena↗
PubMedDate not supplied

Molecular field extrema as descriptors of biological activity: definition and validation.

The paper describes the generation of four types of three-dimensional molecular field descriptors or 'field points' as extrema of electrostatic, steric, and hydrophobic fields. These field points are used to define the properties necessary for a molecule to bind in a characteristic way into a specified active site. The hypothesis is that compounds showing a similar field point pattern are likely to bind at the same target site regardless of structure. The methodology to test this idea is illustrated using HIV NNRTI and thrombin ligands and validated across seven other targets. From the in silico comparisons of field point overlays, the experimentally observed binding poses of these ligands in their respective sites can be reproduced from pairwise comparisons.

Algorithms↗