Biomedical subjects
Publications and source records attributed to Salvio Serrano Ortega.
We present the case of a 55-year-old male with melanoma in the right retroauricular region who had cutaneous necrosis only in one of the injection sites after adjuvant treatment with interferon (IFN alpha 2b) according to the Kirkwood proposed regime. Appearance of cutaneous necrosis is a rare condition that has been described in patients treated with different types of IFN.
Traumatic or amputation neuromas are benign tumours formed by a proliferation of Schwann cells, axons and connective tissue elements. They are secondary to the partial or total section of a nerve pathway due to an accidental or surgical trauma. They can form at any site and affect any type of nerve. The presence of amputation neuromas is very frequent in major surgery but rare in simple excisions of skin tumours. We report two cases with neuroma localized in the neck, one after lymph node dissection for melanoma metastasis and the other after excision of a cutaneous melanoma with 3-cm margin on lateral neck. In both cases, the presence of the neuroma mandated a surgical excision to rule out a possible recurrence of melanoma.
The incidence of lip cancer in Granada, Spain, is much higher than that recorded in other countries. The natural history of the disease generally includes induction on previous actinic lesions, promotion with local growth of the tumour, and the appearance of metastasis in regional lymph node chains and, exceptionally, via the blood stream. In order to determine the risk factors for metastases, a retrospective hospital-based study was conducted of 251 cases of lower lip cancer diagnosed and treated during a 10-year period from 1985 to 1995. All patients studied had a minimum follow-up of five years. Among the metastasis risk factors considered, only localization in commissure showed statistical significance (p < 0.001).