Biomedical subjects

Sandro Leuthardt

Publications and source records attributed to Sandro Leuthardt.

2 recordsLinked to original sources

PubMed2002

Electrophoretic separations with polyether ether ketone capillaries and capacitively coupled contactless conductivity detection.

Polyether ether ketone (PEEK) capillaries were found to be compatible with capacitively-coupled contactless-conductivity detection (C4D). Detection limits in the order of 10(-7) M were obtained with C4D employing a high excitation voltage (HV-C4D) for inorganic cations and anions. The organic polymer capillary shows a relatively low electroosmotic flow of 2.6 x 10(-4) cm2 V(-1) s(-1). Thus inorganic anions and slower organic anions can be separated with a PEEK capillary in a single run without flow modifier. This feature also enables the analysis of both, cations and (fast and slow) anions, in a sample in two subsequent runs just by reversing the polarity or in a single run if dual opposite end injection is employed.

Electrochemistry↗

PubMed2002

Conductimetric and potentiometric detection in conventional and microchip capillary electrophoresis.

Potentiometric detection is rarely used in separation methods but is promising for certain classes of analytes which can only with difficulty be quantified by more standard methods. Conductimetric detection of ions is very versatile and has recently received renewed interest spurned by the introduction of the capacitively coupled contactless configuration. Both are useful and complementary alternatives to the established optical detection methods, and to the more widely known electrochemical method of amperometry. The simplicity of the electrochemical methods makes them particularly attractive for microfabricated devices, but relatively little work has to date been carried out with regard to potentiometric and conductimetric detection.

Conductometry↗