Biomedical subjects

Sangeeta

Publications and source records attributed to Sangeeta.

3 recordsLinked to original sources

PubMed2002

SEM study on cytotoxic effect of monocrotophos (MCP) on lungs of rat.

Monocrotophos (MCP) on oral administration (0.28 mg/100 g of body wt. i.e. 1/5th of LD50) to female rats for 15 and 30 days damaged alveolar walls lined by type II cells (great alveolar cells); clara cells (non-ciliated cells) lining bronchiolar epithelium; and emphysematous lesions due to loss of inter-alveolar walls. This led to increase in surface tension in lung due to decrease in secretion of surfactant as a result of necrosis of great alveolar cells and clara cells resulting in hypoxia. This effect was time dependent. In R group (15 days without pesticide after 30 days daily oral treatment), the toxic effects mentioned above still persisted which revealed non-repair of necrosis caused by MCP.

Animals↗

PubMed2000

Endolaryngeal foreign bodies.

Unusual foreign bodies of the larynx viz. a toy gear, a metallic spring, a safety pin, a piece of stone, lodged in the endolaryngeal region are reported. Radiographic documentation with the rare feature of absence of symptoms inspite of lodgement for long duration is recorded.

Child, Preschool↗

PubMed1993

Effect of macrocomponents of food on the pharmacokinetics of a long acting preparation of anhydrous theophylline.

In a single dose crossover study, the effect of macrocomponents of food on the pharmacokinetics of a long acting preparation of anhydrous theophylline was investigated. Compared to fasting subjects, carbohydrate and fat rich diet caused an enhancement of absorption half life and a lower Cmax with a delayed tmax and elimination of the bronchodilator. Protein coadministration decreased AUCO-OC of the drug without significantly altering its absorption or elimination kinetics.

Absorption↗