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Biomedical subjects

Sanjay R Parikh

Publications and source records attributed to Sanjay R Parikh.

12 recordsLinked to original sources
PubMed2006

Validation of a new grading system for endoscopic examination of adenoid hypertrophy.

OBJECTIVE: To propose and validate a new subjective grading system of adenoid size with flexible fiberoptic evaluation. STUDY DESIGN AND SETTING: Digital video clips of 24 flexible fiberoptic nasopharyngeal exams were presented to 24 examiners (otolaryngology resident and consultant physicians) at a tertiary care institution. Examiners were asked to use the proposed grading system to rate adenoid hypertrophy. Kappa statistical analysis was used to evaluate the degree of intergrader agreement or disagreement. RESULTS: Statistical analysis of intergrader agreement demonstrated an overall Kappa score of 0.71 suggesting a "substantial" strength of agreement. The Kappa strength of agreement was found to be 0.83 (almost perfect) among consultant physicians and 0.62 (substantial) among resident physicians. CONCLUSIONS: The proposed adenoid staging system is a reliable and consistent method of staging adenoid tissue size. SIGNIFICANCE: This new validated grading system may be a useful standard for reporting adenoid size in future clinical outcome studies.

Adenoids↗
PubMed2005

Early extubation following major tracheal surgery in select children.

Major airway surgery in children has traditionally consisted of a period of endotracheal intubation after the procedure for a period of 1-2 weeks to ensure stability of the repair. Recent literature has supported a trend toward decreasing this time period to prevent the consequences of leaving a foreign body in the airway and the morbidity associated with the use of sedation and narcotics in children. We present a series of five select children from our institution that underwent major tracheal surgery and were successfully extubated early in their postoperative course; four on postoperative day number 1. This demonstrates the feasibility of this approach in select patients.

Adolescent↗
PubMed2005

An unusual case of rhabdomyosarcoma presenting as orbital apex syndrome.

PRECIS: A 12-year-old female presented with symptoms and signs of orbital apex syndrome (OAS), secondary to stage IV alveolar rhabdomyosarcoma (RMS) originating in the sphenoid and ethmoid sinuses. OBJECTIVE: To present a case of alveolar rhabdomyosarcoma, unusual in its presentation as orbital apex syndrome and also its origin from the sphenoid and ethmoid sinuses. DESIGN: : Observational case report. METHODS: Ophthalmologic findings, neuroimaging, medical and surgical intervention, histopathologic analysis, and clinical course are described. RESULTS: A 12-year-old female presented with progressive visual loss in her left eye, difficulty with eye movements, and mild headache. Her examination was consistent with orbital apex syndrome. Imaging with contrast revealed a mass originating in the left sphenoid and ethmoid sinuses invading the left optic canal. Emergent biopsy was interpreted as alveolar rhabdomyosarcoma; subsequent metastatic work-up revealed bone marrow metastases. The patient was diagnosed with stage IV alveolar rhabdomyosarcoma and immediately started on combination orbital radiation therapy (RT) and systemic chemotherapy. She experienced gradual improvement of ocular motility, though her optic neuropathy persisted. CONCLUSION: Alveolar rhabdomyosarcoma of paranasal origin, specifically from the sphenoid and ethmoid sinuses, should be included in the differential diagnosis for orbital apex syndrome in children.

Blepharoptosis↗
PubMed2005

Bilateral congenital vocal cord paralysis: a 16-year institutional review.

OBJECTIVE: To review the management and outcome of bilateral congenital true vocal cord paralysis in 22 patients treated over a 16-year period and to review the role of tracheostomy in these patients. DESIGN: Retrospective chart review. SETTING: Pediatric tertiary hospital. PATIENTS: Twenty-two pediatric patients diagnosed with bilateral congenital true vocal cord paralysis. INTERVENTIONS: Flexible or rigid diagnostic evaluation, tracheostomy, and vocal cord lateralization procedures. MAIN OUTCOMES MEASURES: Vocal cord recovery and decannulation. RESULTS: With a mean follow up of 50 months, 15 of 22 patients (68%) with bilateral vocal cord paralysis required tracheostomy for airway securement. Of the 15 tracheotomized patients, 10 were successfully decannulated (8 had spontaneous recovery, whereas 2 required lateralization procedures). Eleven of these patients with tracheostomy had comorbid factors, including neurologic abnormalities (midbrain/brainstem dysgenesis, Arnold-Chiari malformation, global hypotonia, and developmental delay). Of the 7 patients not requiring tracheostomy, 6 recovered vocal cord function (86%). CONCLUSION: In our series of 22 patients with bilateral vocal cord paralysis, 14 had spontaneous recovery of function. Patients managed with tracheostomy were noted to have a high incidence of comorbid factors. In this series, recovery rates were found to be higher in nontracheostomized patients than in tracheostomized patients. Patients can be carefully selected for observation versus tracheostomy at the time of diagnosis based on underlying medical conditions.

Cohort Studies↗
PubMed2004

Pediatric unilateral vocal fold immobility.

Unilateral VFI is a rare entity in the pediatric age group. Initial evaluation should include a thorough history and physical examination, particularly assessing for associated CNS and cardiovascular anomalies. Modalities of investigation include fiberoptic examination, EMG in the older child,diagnostic imaging, and rigid endoscopy. Controversy exists about the relevance of "growth centers" in the developing larynx, although recent studies dispute their existence. Recovery in idiopathic or congenital cases can occur up to 11 years later, which supports some observation between onset of paralysis and surgical intervention. In cases where the etiology is clear and recovery is not anticipated, a few reported series have demonstrated success with endoscopic injection and thyroplasty techniques. Unlike the case in adults, careful identification of the vocal fold level should be performed in children before implant placement. Further research is necessary to prove prospectively that surgical intervention in the pediatric larynx will not affect subsequent growth. Until this occurs, the otolaryngologist will continue to be challenged with decisions regarding the timing and choice of technique for correction of unilateral VFI in neonates and children.

Child↗
PubMed2003

Utility of tonsillectomy in 2 patients with the syndrome of periodic fever, aphthous stomatitis, pharyngitis, and cervical adenitis.

OBJECTIVES: To review the various causes of period fever in childhood, including the syndrome of periodic fever, aphthous stomatitis, pharyngitis, and cervical adenitis (PFAPA), and to examine the value of tonsillectomy in the treatment of PFAPA syndrome. DESIGN: Retrospective case series. SETTING: Urban and tertiary care referral children's hospital. PATIENTS: Two patients who underwent tonsillectomy for presumed recurrent adenotonsillitis were later diagnosed as having PFAPA syndrome. Intervention Tonsillectomy. MAIN OUTCOME MEASURE: Frequency of PFAPA symptoms before and after tonsillectomy. RESULTS: No difference was found in the frequency of PFAPA symptoms after tonsillectomy. CONCLUSION: Although a larger series of patients is required, our initial experience suggests that tonsillectomy is not always beneficial for patients with PFAPA syndrome.

Adolescent↗
PubMed2003

Differences between ventricular repolarization in men and women: description, mechanism and implications.

The purpose of this review article is to discuss the differences between ventricular repolarization in males and females in terms of morphology, possible mechanism, and practical significance. The interest in the subject increased when it became known that in comparison to men, women have a higher incidence of torsade de pointes (tdp) and a greater lengthening of QT-interval after administration of class III antiarrhythmic drugs. Before puberty, the QT intervals and the patterns of ventricular repolarization in boys and girls are similar. At puberty, in boys the QT interval shortens, and a typical male pattern of ventricular repolarization develops. This pattern is characterized by a higher amplitude of the J-point, a shorter and steeper ST segment course, a steeper ascent, and a higher amplitude of the T wave. This pattern is prevalent in >90% of young males. With increasing age the prevalence of the male pattern in males declines gradually and drops to 14% in the oldest age group. The rise and fall of the prevalence of the male pattern appears to parallel the rise and decline of testosterone in males. The female pattern of ventricular repolarization is prevalent in about 80% of females in all age groups. The hormonal effects on ventricular repolarization have been studied in normal and castrated rabbits of both sexes. The available evidence indicates that the females have greater divergence of L calcium current among different layers of the myocardium and a lower density of the repolarizing Kr and Ks currents. The clinical significance of the repolarization differences among genders remains to be determined. Of particular interest is the question whether the males with female pattern are at the same risk of tdp as the females or whether the females with male pattern are at lower risk of tdp than the females with female pattern.

Adolescent↗
PubMed2002

Prevalence of male and female patterns of early ventricular repolarization in the normal ECG of males and females from childhood to old age.

OBJECTIVES: This study was designed to establish the cause of electrocardiographic (ECG) pattern differences between genders. BACKGROUND: The male and female patterns of early ventricular repolarization in normal ECGs differ from each other. The male pattern displays a higher J-point amplitude and increased ST angle. The distribution of these patterns between genders has not been studied. METHODS: Normal ECGs of 529 males and 544 females, age 5 to 96 years, were subdivided into nine age groups in each gender. We designated the pattern as female if the J point was <0.1 mV in each of the leads V(1) to V(4), and as male if the J point was > or =0.1 mV and the ST angle > or =20 degrees in at least one of the V(1) to V(4) leads; the pattern was indeterminate if the J point was > or =0.1 mV and the ST angle was <20 degrees. RESULTS: Distribution of patterns was significantly different between genders (p < 0.001). In females, the patterns were distributed similarly from puberty to advanced age with about 80% prevalence of the female pattern. In males, the male pattern prevalence increased at puberty, reached 91% in the age group of 17 to 24 years and declined gradually with advancing age to 14% in the oldest males. The prevalence of indeterminate pattern was about 10% in both genders. Patterns were unchanged in 95% of 493 subjects who had ECGs recorded at separate times or at different heart rates. CONCLUSIONS: Gender differences in early ventricular repolarization were caused by age-dependent changes in prevalence of the male pattern.

Adolescent↗
PubMed2002

Rotational ablation and stent placement for severe calcific coronary artery stenosis after Kawasaki disease.

We report on a 5-year-old child who had an episode of Kawasaki disease with giant coronary artery aneurysms at the age of 4 months. Surveillance coronary angiography showed severe calcific stenosis in the proximal left anterior descending artery. Balloon angioplasty failed to resolve the obstruction. Rotational ablation was therefore performed. Surveillance angiogram performed 6 months after rotational ablation showed critical restenosis. Rotational ablation was therefore repeated, followed by stent placement. To the best of our knowledge, this is the youngest child who has undergone coronary stenting after Kawasaki disease.

Atherectomy, Coronary↗
PubMed2002

Navigational systems for sinus surgery: new developments.

The last 15 years have seen an explosion in the understanding and treatment of paranasal sinus disease. On the heels of the development of computed tomography (CT), a new modality of paranasal intervention was propagated with the introduction of rigid telescopic technology. In the last 10 years, both computer hardware and software improvements have permitted the otolaryngologist to further this endoscopic ability with CT-guided navigational systems. This article reviews the technology, utility, and advances in the field of image-guided endoscopic sinus surgery.

Forecasting↗