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Biomedical subjects

Sanjeev D Nandedkar

Publications and source records attributed to Sanjeev D Nandedkar.

3 recordsLinked to original sources

Motor unit number index (MUNIX).

The surface-recorded compound muscle action potential (CMAP) and electromyographic (EMG) interference pattern is used to compute the motor unit number index (MUNIX). The MUNIX demonstrated all known changes in the number of motor units in normal subjects, and in patients with amyotrophic lateral sclerosis (ALS). In normal subjects MUNIX decreased slightly with age and showed excellent reproducibility. In many ALS patients MUNIX was reduced even when the CMAP was normal. Lower MUNIX values were seen in weaker muscles. This is a noninvasive method that requires minimal electrical stimulation. It is performed in less than 5 min. This makes it suitable for serial EMG investigations.

Action Potentials↗

Models and simulations in electromyography.

In electromyography, one assesses the pathophysiology on the basis of the waveform characteristics of the recorded signal. This requires detailed knowledge of the relationship between the waveform generators and the waveform measurements. Models and computer simulations can be used to explore this relationship in an efficient manner. Combining models with experimental methods will allow us to define new measurements and new rules of interpretation. This is discussed with some of the models developed for electromyography signal analysis.

Animals↗