Biomedical subjects

Satoshi Adachi

Publications and source records attributed to Satoshi Adachi.

3 recordsLinked to original sources

PubMed2003

Heparin-binding EGF-like growth factor and ErbB signaling is essential for heart function.

The heparin-binding epidermal growth factor (EGF)-like growth factor (HB-EGF) is a member of the EGF family of growth factors that binds to and activates the EGF receptor (EGFR) and the related receptor tyrosine kinase, ErbB4. HB-EGF-null mice (HB(del/del)) were generated to examine the role of HB-EGF in vivo. More than half of the HB(del/del) mice died in the first postnatal week. The survivors developed severe heart failure with grossly enlarged ventricular chambers. Echocardiographic examination showed that the ventricular chambers were dilated and that cardiac function was diminished. Moreover, HB(del/del) mice developed grossly enlarged cardiac valves. The cardiac valve and the ventricular chamber phenotypes resembled those displayed by mice lacking EGFR, a receptor for HB-EGF, and by mice conditionally lacking ErbB2, respectively. HB-EGF-ErbB interactions in the heart were examined in vivo by administering HB-EGF to WT mice. HB-EGF induced tyrosine phosphorylation of ErbB2 and ErbB4, and to a lesser degree, of EGFR in cardiac myocytes. In addition, constitutive tyrosine phosphorylation of both ErbB2 and ErbB4 was significantly reduced in HB(del/del) hearts. It was concluded that HB-EGF activation of receptor tyrosine kinases is essential for normal heart function.

Animals↗

PubMed2002

Divergence-free WKB method.

A new semiclassical approach to the linear and nonlinear one-dimensional Schrödinger equation is presented. For both equations our zeroth-order solutions include nonperturbative quantum corrections to the WKB solution and the Thomas-Fermi solution, thereby allowing us to make uniformly converging perturbative expansions of the wave functions. Our method leads to a new quantization condition that yields exact eigenenergies for the harmonic-oscillator and Morse potentials.

Journal Article↗

PubMed2002

The difference in condylar position between centric relation and centric occlusion in pretreatment Japanese orthodontic patients.

This study investigates the differences in condylar position between centric relation (CR) and centric occlusion (CO) in Japanese orthodontic patients before treatment. We employed 150 consecutive cases (age range: 6-57 years) for the study. Dental casts were mounted on a Panadent articulator with a power centric CR bite record. The differences in condylar position between CR and CO in all three spatial planes were measured using the Panadent Condyle Position Indicator (CPI). The subjects were divided into groups by age, gender, mandibular plane angle or angle classification. No significant differences in the magnitude of CPI measurements were found among the groups. The three-dimensional distances of condylar displacement on both sides were almost identical, and the superoinferior displacement (S-I) was greater (P < .0001) than the anteroposterior displacement (A-P). The S-I was greater (P = .02) on the left side than on the right side, while the A-P displacement was smaller (P < .0001) on the left side than that on the right side. Significant condylar displacement (2.0 mm for S-I and A-P, 0.5 mm for the lateral displacement, L) was found frequently in L (31.3%), S-I, and A-P, in that order. Fifty-eight (38.7%) of the subjects had significant displacement in L, S-I, or A-P. Moreover, Angle Class III subjects tended to have significant condylar displacement toward the left side. The results suggest that orthodontists should be aware of a high incidence of condylar displacement in Japanese orthodontic patients and measure condylar displacement before the start of comprehensive orthodontic treatment to unmask real jaw relationships and avoid possible misdiagnoses.

Adolescent↗