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Biomedical subjects

Satoshi Soen

Publications and source records attributed to Satoshi Soen.

5 recordsLinked to original sources
PubMed2006

[Guidelines for the treatment of glucocorticoid-induced osteoporosis and their future problems].

Osteoporosis is the most frequent adverse effect of glucocorticoids. Management guidelines for glucocorticoid-induced osteoporosis have been established in the United States, the United Kingdom, and many other countries. The 2004 edition of the guidelines on the management and treatment of glucocorticoid-induced osteoporosis have been proposed by The Japanese Society for Bone and Mineral Research. The subjects were patients with using or planning to use oral glucocorticoids for 3 months or longer. The criterion for starting treatment was patients with prior fragility fracture and with new fractures during treatment, patients with less bone mineral density (BMD) than 80% of young adult mean, and patients with using as a dose of 5mg/day or higher (mean daily dose) as prednisolone equivalent. The bisphosphonates have been recommended as first-line drugs and active vitamin D(3) and vitamin K(2) have been recommended as second-line drugs.

Bone Density↗
PubMed2005

Glucocorticoid-induced osteoporosis: skeletal manifestations of glucocorticoid use and 2004 Japanese Society for Bone and Mineral Research-proposed guidelines for its management.

Glucocorticoid (GC) is widely used to treat a variety of inflammatory and allergic diseases, and about 0.9% of the adult population in Japan (approximately one million people) are known to take oral GC at any given time. GC causes a number of significant side effects, among which are skeletal manifestations such as osteoporosis and degenerative bone fracture, maor complications of GC therapy. Although the population of GC-induced osteoporosis patients is estimated to be approximately one-fifth of patients with primary osteoporosis, few physicians are aware of the increased risk of fracture caused of GC, and there is inadequate information concerning the effetiveness of prevention and treatment of GC-induced osteoporosis. Recently, mechanisms of GC-induced osteoporosis have been clarified, and treatment strategies have been developed. Accordingly, the 2004 Japanese Society for Bone and Mineral Research (JSBMR)-proposed guidelines for the management and treatment of GC-induced osteoporosis have been developed based on the results of a longitudinal study by subcommittee members and the results of an analysis of patients collected by the Subcommittee to Study Diagnostic Criteria for Corticosteroid-induced Osteoporosis, together with evidence obtained overseas and in Japan. The present guideline is prepared for clinical practice.

Journal Article↗
PubMed2005

[Management of glucocorticoid-induced osteoporosis].

Osteoporosis is the most frequent adverse effect observed during glucocorticoids therapy. The 2004 edition of the guideline on the management and treatment of glucocorticoid-induced osteoporosis has been proposed by The Japanese Society for Bone and Mineral Research. The subjects were patients with using or planning to use oral glucocorticoids for 3 months or longer. The criterion for starting treatment consisted patients with prior fragility fracture and with new fractures during treatment, patients with less BMD than %YAM80, and patients with using as a dose of 5 mg/day or higher (mean daily dose) as prednisolone equivalent. The Bisphosphonates have been recommended as first-line drugs. Active vitamin D3 and vitamin K2 have been recommended as second-line drugs.

Bone Density↗
PubMed2005

[Secondary osteoporosis and bone quality].

In secondary osteoporosis, rheumatoid arthritis patients showed high bone turnover and the same cut-off value in bone mineral density as postmenopausal osteoporosis. On the other hand, Glucocorticoid-induced osteoporosis showed low bone turnover and the higher cut-off value compared with postmenopausal osteoporosis. Examination about secondary osteoporosis except these conditions is needed.

Arthritis, Rheumatoid↗