Feature multiplexing--improving the efficiency of microarray devices.
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Base Sequence↗
Biomedical subjects
Scott M Grayson
Publications and source records attributed to Scott M Grayson.
An efficient route to well-defined macrocyclic polymers via "click" cyclization.
Polystyrene macrocycles have been prepared from ATRP precursors by modification of the terminal bromide to an azide, followed by "click" cyclization with a pendant alkyne from the initiator. This route offers exceptional control over the size and polydispersity of the macrocyclic polymers, as well as providing tolerance to a number of functional groups.
Cyclization↗
Synthesis and characterization of norbornanediol isomers and their fluorinated analogues.
[reaction: see text] Fluorinated norbornene monomers exhibit the requisite properties for inclusion in 157 nm photoresists, but traditional addition and radical polymerizations with these monomers have failed. Norbornanediols provide an alternate route to these materials via condensation polymerization, and methods have been developed for the efficient synthesis of the exo-2-syn-7- and endo-2-exo-3-dihydroxynorbornanes. Synthesis of the fluorinated analogues is complicated by steric and electronic effects; however, a high-yielding synthesis of endo-2-exo-3-dihydroxynorbornane bearing a 5-endo-[2,2-bis(trifluoromethyl)hydroxyethyl] substituent is reported.
Journal Article↗
A new approach to heterofunctionalized dendrimers: a versatile triallyl chloride core.
A reactive triallyl chloride moiety was prepared as a suitable core for aliphatic polyether dendrons. In addition to allowing access to fourth generation dendrimers, this core contains three alkene functionalities that can be modified after dendrimer formation and used for further dendritic growth.
Binding Sites↗