Biomedical subjects

Sedat Kalaycioglu

Publications and source records attributed to Sedat Kalaycioglu.

4 recordsLinked to original sources

PubMed2006

Free intra-abdominal hemorrhage after open-heart surgery: an unusual gastrointestinal complication.

Gastrointestinal complications after open-heart surgery are rare. Many preoperative, intraoperative, and postoperative factors may predispose patients to these complications or cause them. Our patient was a 64-year-old woman who underwent aortic valve replacement due to aortic stenosis. Free intra-abdominal hemorrhage occurred on the 2nd postoperative day. During exploratory laparotomy, it was determined that the hemorrhage was from a vein near the falciform ligament of the liver and from a bleeding laceration of the splenic capsule. The complication was repaired surgically. To our knowledge, intra-abdominal hemorrhage of both liver and spleen after open-heart surgery has never been reported before, even in large patient series. We report the case and present our ideas regarding the cause of the bleeding.

Aortic Valve Stenosis↗

PubMed2005

Protective effect of aprotinin against lung damage in patients undergoing CABG surgery.

OBJECTIVE: We investigated the protective effects of aprotinin, administered in the pulmonary artery, on lung damage after cardiopulmonary bypass (CPB). METHODS: A total of 20 patients undergoing elective coronary artery bypass grafting operations was included in the study and divided into two groups. In the aprotinin group (study group) (n = 10) the drug was administered in the pulmonary artery (15,000 KIU/min) via the pulmonary artery catheter. The control group (n = 10) received only placebo. Blood gas measurements, respiratory function tests, malondialdehyde (MDA), nitric oxide (NO), C4 and leukocyte counts were determined as parameters. Blood samples were taken before and after cross clamping. Lung biopsies were taken before and after CPB. RESULTS: In the aprotinin group, forced expiratory volume (FEV1) and paCO2 values were better than in the control group. The postclamping MDA value in the study group was 20.6 +/- 8.7 etamol/ml and in the control group 37.5 +/- 9.6 etamol/ ml. The post clamping NO value in the study group was 261.9 micromol/l and in the control group 147.20 +/- 27.6 micromol/l. C4 levels were found to be better in the study group than in the control group: reduced levels of C4 were found to be statistically significant (study group postclamping: 12.98 +/- 2.63 mg/dl vs. control group 20.6 +/- 11.81 mg/dl). The increase in leukocyte count was found to be statistically significant (12.63 +/- 3.83 x 10(3) vs. 7.27 +/- 1.72 x 10(3). The difference between the preoperative and postoperative FEV1 in the control group was statistically significant. A statistically significant difference was found in the postoperative FEV1 in both groups. CONCLUSION: Aprotinin administered in the pulmonary artery during CPB had a protective effect against lung damage after open-heart surgery.

Aprotinin↗

PubMedDate not supplied

Brucella endocarditis with repeated mitral valve replacement.

Brucella endocarditis, although a rare complication of brucellosis, is a life threatening and often under-diagnosed complication. Despite its high mortality rate with combined medical and surgical treatment, has a low occurrence rate in cases of brucellosis. Here we describe a patient who underwent mitral valve replacement for 3 times due to underdiagnosis of Brucella endocarditis. If a valve replacement fails because of an unknown reason, the doubt of a Brucella infection should be kept in mind for accurate treatment of such patients.

Adult↗

PubMedDate not supplied

Effects of ischemic preconditioning in human heart.

BACKGROUND: The aim of this study is to investigate the effects of ischemic preconditioning (IP) on myocardium and the level of nitric oxide (NO) in patients undergoing aorta-coronary bypass surgery. METHODS: Twenty consecutive patients with coronary artery disease were subjected into two equal groups; the IP group and the control group. Following the onset of cardiopulmonary bypass in the study group, hearts were preconditioned with two 3-minute periods of cross-clamping separated by 2 minutes of reperfusion. In the control group, cardiopulmonary bypass was continued for 10 minutes without using cross-clamp. Arterial and coronary sinus blood samples were used to determine serum NO, malondialdehyde (MDA), creatine phosphokinase-MB (CKMB), and lactate dehydrogenase (LDH) levels. Need for defibrillation after cross-clamp removal, ECG changes, postoperative arrhythmias, ejection fraction, and fractional shortening rates were recorded as hemodynamic data. RESULTS: Serum NO level was higher in the study group 5 minutes after aortic clamp removal (199.3 +/- 92.7 vs. 112.2 +/- 35.8 micromol; p = 001). Serum MDA (2.55 +/- 0.4 vs. 4.06 +/- 0.5; etamol/ml; 5 minutes after the aortic clamp removal; p = 0.0002); CK-MB (22.8 +/- 2.5 vs. 37.4 +/- 4.1; U/L 12 hours after the operation, p < 0.0001), and LDH (501.8 +/- 46.7 vs. 611.4 +/- 128.3; IU/L 48 hours after the operation, p = 0.02) levels were significantly lower in the preconditioned group when compared with the control group. Also, need for electrical defibrillation was significantly lower in the study group; Ejection fraction (64.3 +/- 6.3 vs. 57.6 +/- 7.6; p = 0.04) and fractional shortening (31.7 +/- 3.9 vs. 26.2 +/- 4.0; p = 0.04) rates were better in the study group postoperatively. CONCLUSIONS: These data may suggest that cardioprotection by ischemic preconditioning offers higher NO production, a lower myocardial ischemia, and better functional recovery of the hearts in coronary artery surgery patients.

Aged↗