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Biomedical subjects

Seema Sen

Publications and source records attributed to Seema Sen.

At least 19 recordsLinked to original sources
PubMed2007

Unilateral congenital corneal keloid with anterior segment mesenchymal dysgenesis and subluxated lens: case report and review of literature.

PURPOSE: To report the unusual association of unilateral congenital corneal keloid with anterior-segment mesenchymal dysgenesis and bilateral subluxated lens. METHODS: A 20-year old man presented with a mass lesion involving the left cornea. The corneal lesion had been present since birth. On biomicroscopic examination, a well-defined vascularized, grayish-white mass occupying the whole of the left cornea was seen. The right eye showed multiple peripheral corneal opacities with iridocorneal adhesions, a poorly defined supranasal limbus, and a subluxated lens. Excision biopsy of the mass was done for histopathologic examination. RESULTS: Histopathologic examination of the excised corneal mass showed features consistent with that of a corneal keloid: thickened keratinized epithelium, absent Bowman membrane layer, and fibrovascular hyperplasia composed of hyalinized collagen fibers with irregular orientation of the collagen lamellae. During penetrating keratoplasty of the left eye, an anomalous iris pattern with poorly defined angle and a supranasal subluxated lens was also observed. Extraction of the subluxated lens was also done. The graft failed subsequent to a nonhealing persistent epithelial defect. CONCLUSION: Our case report highlights the rare association of a unilateral congenital corneal keloid with anterior-segment mesenchymal dysgenesis and bilateral subluxated lens.

Adult↗
PubMed2006

Bilateral dissociated vertical deviation in a case of congenital hereditary endothelial dystrophy.

Dissociated vertical deviation (DVD) is an intermittent anomaly of the non-fixing eye. Although association of DVD with sensory visual deprivation owing to congenital or acquired opacities of the ocular media has been reported, its association with congenital hereditary endothelial dystrophy (CHED) has not been reported hitherto. We report a case having a bilateral asymmetric DVD, in a know case of bilateral CHED.

Child, Preschool↗
PubMed2005

Indications of penetrating keratoplasty in northern India.

PURPOSE: To identify the indications for penetrating keratoplasty in northern India. METHODS: All the eye bank records of penetrating keratoplasties performed during the period from June 1997 to November 2003 at Rajendra Prasad Center for Ophthalmic Sciences were reviewed. RESULTS: During this period, 2022 penetrating keratoplasties were performed. The leading indications for penetrating keratoplasty were corneal scarring (38.03%) followed by acute infectious keratitis (28.38%), regrafting (11.5%), aphakic bullous keratopathy (7.27%), pseudophakic bullous keratopathy (6.18%), and corneal dystrophy (3.85%). Healed infectious keratitis (19.83%) was the most common subcategory among the eyes with corneal scarring followed by traumatic corneal scars (16.71%). Healed (19.83%) and active keratitis (28.38%) together accounted for the majority of keratoplasties (48.21%). In cataract-related corneal edema (13.45%), aphakic bullous keratopathy (7.27%) was almost as frequent as compared with pseudophakic bullous keratopathy (6.18%). CONCLUSIONS: Corneal infections either active or healed are the most common indication for keratoplasty in northern India.

Adolescent↗
PubMed2005

Orbital ectopic glial tissue in relation to medial rectus: a rare entity.

Heterotopic brain tissue is a rare entity and it is rarer still in the orbit. There have been very few case reports of orbital ectopic glial tissue. The case is described herein of a 3-month-old baby presenting with an orbital glial hamartoma inseparable from the medial rectus muscle. The diagnosis was based on the histopathological features and a positive GFAP stain. The features of this case and the previously reported cases are discussed.

Brain↗
PubMed2004

Langerhans cell histiocytosis presenting as a limbal nodule in an adult patient.

PURPOSE: To report a case of Langerhans cell histiocytosis presenting as a limbal nodule. DESIGN: Observational case report. METHOD: A 26-year-old man presented with a superior limbal mass. On clinical examination, an infiltrative/neoplastic lesion was suspected, and a differential diagnosis of limbal amyloidosis, limbal fibrous histiocytoma, lymphoma, and juvenile xanthogranuloma was made. There was no other associated ocular or systemic abnormality. An excision biopsy was performed. RESULTS: The histopathology and immunohistochemical staining examination established the diagnosis of limbal Langerhans cell histiocytosis. CONCLUSION: To the best of our knowledge, this is an unusual presentation of Langerhans cell histiocytosis, and although rare, Langerhans cell histiocytosis should be included in the differential diagnosis of a limbal mass.

Adult↗
PubMed2004

Pattern of orbital exenteration in a tertiary eye care centre in India.

PURPOSE: This study aimed to determine the clinical indications for orbital exenteration, profile of these patients and clinicopathological correlations, and to compare these results with previous published data. METHODS: A retrospective analysis was conducted of exenterations performed in adults at a tertiary eye care centre in India over a period of 10 years (January 1990 to December 2000). Patient records were reviewed to obtain demographic data, presenting symptoms and their duration, laterality, and clinical and histopathological diagnosis. RESULTS: A total of 26 cases were identified. Patients ranged in age from 32 to 72 years (mean +/- SD 58.7 +/- 9.23 years). No sex predilection was observed. Classification of cases on histopathological criteria showed that exenterations were performed mostly for squamous cell carcinoma (10 cases), followed by sebaceous gland carcinoma (six cases) and basal cell carcinoma (two cases) of the eyelid. Conjunctival malignant melanoma contributed to 5 of 26 cases of exenteration. Adenoid cystic carcinoma of the lacrimal gland (one case), neurofibroma (one case) and orbital fungal infection (one case) were the other indications of exenteration. The clinicopathological correlation was 100% for squamous cell carcinoma, 100% for basal cell carcinoma, 80% for malignant melanoma and 75% for sebaceous gland carcinoma. CONCLUSION: Exenteration is mainly performed as a life-saving treatment for advanced malignant tumours with epithelial tumours being the commonest. In comparison to previous published data, the indications of surgery in India differed, as squamous cell carcinoma and sebaceous gland carcinoma were the commonest indications for exenteration.

Adult↗
PubMed2004

Pleomorphic adenomas of the lacrimal gland: a clinicopathological analysis.

PURPOSE: To analyse retrospectively 32 cases of pleomorphic adenoma of the lacrimal gland diagnosed over a 10-year period in a tertiary referral eye centre from North India. METHODS: The clinical features of 32 cases of pleomorphic adenomas diagnosed between 1991 and 2000 were analysed and the histopathological features reviewed light microscopically. RESULTS: Among the clinical features, a marked male predominance with younger age of presentation and left-sided dominance was noted. The duration of symptoms was less than 10 months in 28% cases. Histopathologically, the features included presence of cystic degeneration (15.6%) and squamous metaplasia (18.7%). Calcification, osteoid formation and malignant transformation (3.1% each) were occasionally observed. CONCLUSIONS: Pleomorphic adenomas of the lacrimal gland may present with duration of symptoms of less than 10 months. Cystic degeneration, squamous metaplasia, calcification or ossification may be observed in lacrimal gland pleomorphic adenomas, as has been described in pleomorphic adenomas of salivary glands. However, the presence of calcification and bone erosion radiologically in a lacrimal gland tumour does not necessarily indicate malignancy.

Adenoma, Pleomorphic↗
PubMed2003

Primary orbital plasmacytoma: A case report.

A 50-year-old man presented with a fungating growth in the left eye of 3 months duration. Biopsy of the mass followed by light microscopy was suggestive of plasmacytoma and the diagnosis was confirmed by immunohistochemical stains, which demonstrated monoclonality to kappa light chains. Systemic investigations ruled out a multiple myeloma. The patient received radiotherapy; however, due to a residual mass, the left orbit had to be exenterated. Solitary plasmacytomas may not always be completely radiosensitive and radical surgery may be required in such cases. Immunohistochemical stains for kappa and lambda light chains can prove useful in confirming the diagnosis of suspected plasmacytomas.

Combined Modality Therapy↗
PubMed2003

Conjunctival rhinosporidiosis.

Conjunctival rhinosporidiosis is usually a surprise diagnosis in histological section of an excised conjunctival mass. The condition is rarely encountered outside the endemic coastal areas of South India. Accurate diagnosis of this rare condition is infrequent in clinical practice; tumour, neoplasm, papilloma being the common misdiagnoses. Herein, a report of a case of an 18-year-old otherwise healthy male who attended outpatient department of Regional Institute of Ophthalmology, Medical College, Kolkata with a red fleshy papillomatous growth about 7 mm x 4 mm in size, in the palpebral conjunctiva just behind the intermarginal strip of his right upper lid. His routine blood examination was within normal limits. The growth was excised under local anaesthesia and histopathological examination revealed rhinosporidiosis. There was no recurrence of the growth within one month of follow-up.

Adolescent↗
PubMed2002

Diagnostic intraocular aspiration cytology of choroidal melanoma.

Fine-needle aspiration cytology (FNAC) was performed on an intraocular mass in a 32-yr-old Indian woman and a cytologic diagnosis of malignant melanoma was made, supported by immunocytochemistry. The cytologic features included spindle-shaped tumour cells with minimal pleomorphism and the presence of nuclear grooves. No intracellular pigment was identified; however, positivity for HMB-45 allowed a rapid and reliable diagnosis. The utility of FNAC in an atypical presentation of choroidal melanoma is discussed.

Adult↗
PubMed2002

Neurofibroma of the lacrimal sac.

Neurofibroma is an extremely rare neural tumor of the lacrimal sac. We present a case of neurofibroma of the lacrimal sac in a 45-year-old lady. Based on the history of intermittent epiphora, presence of a mass in the lacrimal sac region, dacryocystogram suggestive of space occupying lesion within the lacrimal sac and computed tomographic image of a tumor lying in the lacrimal fossa region, a tentative diagnosis of lacrimal sac neoplasm was made. Excision of the tumor with repair of the lacrimal sac was performed. Histopathology proved it to be neurofibroma of the lacrimal sac. Until now, only four cases have been reported worldwide. The paucity of reported cases limits our knowledge regarding the natural course, treatment, results and prognosis of this tumor.

Eye Neoplasms↗
PubMedDate not supplied

Simple dacryops: a case series and review of the literature.

In this prospective, small case series, 3 patients with simple dacryops were analyzed along with a review of literature. All 3 patients in this series had classical clinical features of simple dacryops. All of them underwent complete cyst removal with the aid of a cryoprobe. Histopathology was compatible with dacryops. In 2 of the 3 patients, the cyst revealed calcification, which to the best of our knowledge has not been reported. None of the patients developed a recurrence. In conclusion, simple dacryops is an easily recognized clinical entity. This entity has been infrequently reviewed in the older literature, and in the last decade only 6 cases have been reported. Most of the patients underwent complete excision of the cyst with no recurrences.

Adult↗
PubMedDate not supplied

Orbital spread of conjunctival squamous cell carcinoma following evisceration: a reminder of the importance of thorough evaluation before and after destructive surgery.

Evisceration is a neglected surgery usually performed by the most junior ophthalmologists in unsalvageable eyes with panophthalmitis. It is universal knowledge that evisceration is contraindicated in eyes with intraocular malignancy. We report 2 patients who presented to us with squamous cell carcinoma (SCC) in eviscerated sockets. While one of them was diagnosed with SCC on histopathological examination of the eviscerated contents, the other had history suggestive of conjunctival SCC prior to evisceration. The second patient presented to us with complaints of poorly fitting prostheses. We conclude that it is imperative to rule out not just intraocular but also adnexal malignancy prior to evisceration, and these eyes should be regularly followed up and carefully examined if poor fitting of the prostheses develops.

Adult↗