Biomedical subjects

Seymour Brownstein

Publications and source records attributed to Seymour Brownstein.

22 records · Page 2Linked to original sources

PubMedDate not supplied

Conjunctival mucoepidermoid carcinoma in a patient with ocular cicatricial pemphigoid and a review of the literature.

Invasive mucoepidermoid carcinoma of the conjunctiva of the left lower eyelid was diagnosed in an orbital exenteration specimen of a 57-year-old woman, after a biopsy of the same lesion was originally diagnosed as invasive squamous cell carcinoma. The woman was undergoing mitomycin C injections for ocular cicatricial pemphigoid, diagnosed in the same eye 2 years prior to identification of the neoplasm. The tumor invaded the cornea, sclera, lacrimal gland, regional small nerves, and lymphatics, but did not show intraocular involvement. The original biopsy specimen was reassessed with stains for mucin and found to be mucoepidermoid carcinoma of the conjunctiva. We reviewed 21 cases of mucoepidermoid carcinoma of the conjunctiva described to date in the English literature. We believe this number underestimates the true incidence of this condition, as it is frequently misdiagnosed both clinically and histopathologically. Evaluating suspected aggressive squamous cell carcinoma with special stains for mucin generally helps to identify mucoepidermoid carcinoma of the conjunctiva. More extensive surgical excision than that used for squamous cell carcinoma should be implemented in the management of mucoepidermoid carcinoma of the conjunctiva to prevent recurrence.

Basement Membrane↗

PubMedDate not supplied

Cicatricial conjunctival inflammation with trichiasis as the presenting feature of Wegener granulomatosis.

Wegener granulomatosis has a variety of uncommon initial presentations. Although conjunctival involvement in this condition is rare, the diagnosis of Wegener granulomatosis should be suspected when the conjunctival inflammation is recurrent and not typical of other conjunctival inflammatory conditions.

Aged↗

PubMedDate not supplied

Infected aluminum oxide orbital implant.

Porous orbital implant infection is rare. The diagnosis may be delayed as the initial symptoms and signs are not always indicative of implant infection. It is often only with time, a persistence of symptoms and signs, and additional symptoms and signs that implant infection is suspected.

Aluminum Oxide↗

PubMedDate not supplied

Malignant melanoma of the conjunctiva.

BACKGROUND: Conjunctival melanoma is a relatively rare ocular malignancy with substantial associated morbidity and mortality. METHODS: More than 100 articles on conjunctival melanoma were reviewed, including most of the relevant recent publications cited in a current MEDLINE search. The author's experience with conjunctival melanomas is also incorporated in this review. RESULTS: Recognition of their precursor lesions at an early stage is important. Staging of the disease by sentinel lymph node biopsy is now advocated in some centers. Surgical excision with adjuvant cryotherapy and alcohol corneal epithelialectomy is usually effective in eradicating most of these lesions. Extensive cases of flat primary acquired melanosis with atypia may be managed with mitomycin C. Multifocal and advanced melanoma, especially in cases showing intraocular or orbital invasion, may require exenteration and/or radiotherapy to adequately extirpate the neoplasm locally. However, systemic metastases already may have occurred in these patients with advanced disease. CONCLUSIONS: Conjunctival melanoma is a condition of concern because of its rarity and lethal potential. Advances in the understanding and management of this neoplasm have markedly reduced the mortality and possibly the morbidity associated with this malignancy.

Brachytherapy↗