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Sh Erdes

Publications and source records attributed to Sh Erdes.

29 records · Page 2Linked to original sources
PubMed1994

[The epidemiology of spondylarthropathies among the native inhabitants of Chukotka (Eskimos and Chukchi). 1. The prevalence of spondylarthropathies among the Eskimos and the coast Chukchi].

To establish the prevalence of spondyloarthropathies among the indigenous population of Chukot Peninsula, a one-stage cross-sectional study was made with a direct medical examination of the natives of the two settlements of Eastern Chukot Peninsula: Sireniki and Novo-Chaplino where the main part of Eskimos live. During expedition, 640 natives aged over 6 years lived in both settlements (382 and 258 respectively). 464 persons (72.5%) were examined. Of these, 7 persons (1.5%) were diagnosed to suffer from diseases belonging to the group of spondyloarthropathies: 2 persons (0.4%) had ankylosing spondyloarthritis, 2 (0.4%) Reiter's syndrome, 2 undifferentiated spondyloarthropathies, and 1 juvenile chronic arthritis. Of the 7 patients, 4 were Eskimos, 2 half-breeds and 1 was a Chukchi man. The incidence of ankylosing spondyloarthritis among Eskimos amounted to 0.9%, Reiter's syndrome to 0.5%, and undifferentiated spondyloarthropathies to 0.5%. Thus the one-stage expedition examination of the indigenous population of Chukotka Peninsula (Eskimos and Chukchi) has shown that diseases belonging to the group of spondyloarthropathies are widely prevalent among Eskimos.

Adolescent↗
PubMed1991

[Genetic determination of rheumatoid arthritis. Distribution of certain Mendelian markers in the light of correspondence of the disease heritability to the model of single autosomal two-allele locus with incomplete penetrance].

The study on the nature of distribution of certain mendelian markers aimed at specifying their role in determination of rheumatoid arthritis disease was carried out, based on the material from the Family Data Bank of the Department of Epidemiology and Genetics of the rheumatic diseases in this institute comprising data on 200 families of patients with definite rheumatoid arthritis (RA). Antigens of HLA-system (the loci A, B, DR), ABO blood groups, Rh, MN and P, phenotypes of acid erythrocyte phosphatase and the types of haptoglobin were studied. Based on the data from this and the previous studies, it is established that the steadiest deviations of the RA patients groups from the general population concerned the frequency of HLA A11, B12, B27 and DR4, blood group P and phenotypes of the acid erythrocyte phosphatase. When using additional controls--a group of healthy mothers of women-probands from the families with the type of marriage "healthy x healthy", and analysing some pair combinations of the HLA system antigens, it was demonstrated that the most clearly their role in formation of the disease display the antigens DR4, and in their absence--DR3, and B12, whereas accumulation of A11 and B27 depended on the presence of other antigens of HLA loci--A and B. Taken together, these data may imply that genetic markers under study serve, when in certain combinations, as "modifiers" of the major gene, or, in a general case, of major genes of multifactorial disease affecting its appearance and clinical manifestations.

Acid Phosphatase↗
PubMed1991

[Genetic determination of rheumatoid arthritis].

The study on the nature of genetic determination of the definite rheumatoid arthritis (RA) and its forms was carried out, based on the material comprising clinical data on 189 probands and their 1st and 2nd degree relatives (713 subjects) which is contained in the computer Family Data Bank at the Department of Epidemiology and Genetics of this institute. The heritability coefficient "in narrow sense" (80%) obtained within the framework of the multifactorial threshold model confirmed once more important role of genetic factors in the appearance of the disease. The study of genetic heterogeneity within the framework of the Ch. Smith's and T. Reich's models failed to reveal any independent genetically RA forms. An assumption of the essential role of the genes localized in the X chromosome, based on diverse susceptibility of sexes, received no conformation. It has been shown that the RA distribution in the population and families may well be described by means of a variant of the single autosomal two-allele locus model with incomplete and differentiated for two sexes penetrance. The model parameters obtained, a particular penetrance of the mutant homozygote in both sexes equalling 100%, and penetrance of the normal homozygote equalling 0 in men and reaching 0 (0.028%) in women testify to a very essential influence of the major gene on determination of RA.

Arthritis, Rheumatoid↗
PubMed1989

[The development and testing of diagnostic criteria in psoriatic arthritis].

The paper is concerned with diagnostic criteria of psoriatic arthritis developed by the expert method. The criteria include 14 signs with the aid of which one can diagnose classical, definite and probable psoriatic arthritis. The sensitivity of the developed diagnostic criteria tried in 108 patients afflicted with psoriatic arthritis constitutes 99.2%, whereas the specificity tested in patients suffering from related diseases (reactive arthritides, ankylosing spondyloarthritis, seronegative rheumatoid arthritis) amounts up to 77.8%.

Arthritis, Psoriatic↗
PubMed1988

[The role of hereditary factors in the development of psoriatic arthritis and the nature of its interrelations with psoriasis].

Altogether 83 families of probands with psoriatic arthritis and the same number of families of probands with common skin psoriasis were investigated in order to study the role of hereditary factors in the development of psoriatic arthritis and the type of its interrelationship with psoriasis. Obvious accumulation of repeated cases of this disease was observed among the probands' relatives. Genetic analysis made it possible to reject the monogenic type of inheritance of psoriatic arthritis and to prove the multifactorial nature of its inheritance confirmed in 68%. Analysis of the distribution of repeated cases of psoriatic arthritis and uncomplicated psoriasis in both types of families helped to determine a genetic correlation coefficient (0.93) indicating great similarity of the genetic systems of both types of diseases therefore they could be regarded as the clinical variants of one disease--psoriasis.

Adult↗
PubMed1986

[Histocompatibility antigens in psoriatic and seronegative rheumatoid arthritis].

Antigens of A and B loci of the histocompatibility system were investigated in 173 patients: 35 with psoriatic arthritis, 38 with seronegative rheumatoid arthritis, 80 with seropositive rheumatoid arthritis and 20 with uncomplicated psoriasis. The results of typification showed that B13 antigen was common in every other patient with uncomplicated psoriasis or psoriatic arthritis, and in the patients with seronegative rheumatoid arthritis it was much more common than in the patients with seropositive rheumatoid arthritis or in the population. Proceeding from the authors' and literature data it was assumed that as a matter of fact, part of the patients (about 15%) with seronegative rheumatoid arthritis had rheumatoid-like psoriatic arthritis without skin manifestations.

Adult↗
PubMed1986

[Status of tissue microcirculation in psoriatic arthritis].

Microcirculation (the skin and skeletal muscle) was studied using a method of 133Xe clearance from the interstitial depot in 35 patients with psoriatic arthritis. It showed significant microcirculatory disorders expressed in a statistically significant decrease in the effective cutaneous blood flow in unaffected skin zones (mostly in women and in a high inflammatory activity of the process) and in the muscular microcirculation especially noted in the period of reactive hyperemia. The results obtained indicate the presence of generalized involvement of the microcirculatory bed vessels in psoriatic arthritis.

Adult↗
PubMedDate not supplied

[DNA typing of allelic variants of HLA-B27: HLA-B*2705 is the predominant allele of the aboriginal population of the Chukot peninsula (Eskimos and Chukchi)].

The purpose of the study was to estimate the relative frequency of the known HLA-B27 subtypes among HLA-B27 positive Chukot natives. Using oligotyping of the polymerase chain reaction amplified second and third exons of the HLA-B27 gene in 86 DNA samples from HLA-27 positive individuals were success-fully typed. All had HLA-B*2705, including nine patients with ankylosing spondylitis and Reiter's syndrome, except for one Eskimo who had HLA-B*2702. None had HLA-B*2704, a frequent subtype in Orientals. Considering the HLA-B27 subtypes, the Chukot population groups are genetically more closely related to Caucasians than to Orientals.

Alleles↗