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Biomedical subjects

Sh G Guseĭnov

Publications and source records attributed to Sh G Guseĭnov.

12 recordsLinked to original sources
PubMed1991

[Immunologic status of alcoholic patients with pulmonary tuberculosis].

Monoclonal antibodies were used to study the T and B immunity systems in 60 alcoholic patients suffering from pulmonary tuberculosis. The patients with that combined pathology demonstrated marked immunodeficiency as regards the T system and an increase of humoral immunity. It is assumed that one of the main causes of immunodeficiency lies in the blockade of the differentiation of T cells at the stage of T prothymocytes. The rise of the level of humoral immunity is connected to a decline of T suppressors. Administration of thymalin to patients with associated alcoholism and pulmonary tuberculosis was found to be highly effective.

Adult↗
PubMed1986

[Secretion of somatotropic hormone in patients with pancreatitis].

The concentration of somatotropic hormone (STH) was measured by radioimmunoassay in 108 patients with acute and chronic pancreatitis and in 15 healthy persons. In addition, to study the reserve capacity of the somatotropic function of the pituitary, insulin hypoglycemia was employed. It was established that during exacerbation, the pancreatitis patients manifested an increase in the hormone content. In the patients suffering from acute pancreatitis, the STH level returned to normal following treatment. In chronic pancreatitis, the hormone concentration remained elevated after treatment. No correlation was discovered between alterations in the STH level and the activity of pancreatic enzymes. The data obtained point to a definite role of STH in the pathogenesis of chronic pancreatitis.

Acute Disease↗
PubMedDate not supplied

[Changes in the function of the hypothalamo-hypophyseo-adrenal system and the thymus as affected by corticotropin in guinea pigs].

Functional state of the hypothalamic-hypophyseal-adrenal system and the thymus was studied in thymic hypo- and hyperplasia of guinea pigs. It was detected that thymomegalia is accompanied by STH and prolactin hyperproduction in adeno-hypophysis, intensified lymphopoiesis (at the expense of T-lymphocytes) and the adrenal glucocorticoid function inhibition, resultant of the lowered ACTH secretion, as well as by the enhanced catecholamine and serotonin content in the hypothalamus. Reverse changes are seen in thymic hypoplasia following intramuscular ACTH injection in a dose 1 U/kg/day within 5 to 10 days.

Adrenocorticotropic Hormone↗
PubMedDate not supplied

[Hormonal and immunological status of children with thymus hyperplasia].

The state of the adrenocortical system, cellular and humoral immunity was studied in 152 infants, suffering from thymomegaly, associated with virus-bacterial pneumonia. The results obtained allow one of to consider the hormonal and immunological state of the patients with thymomegaly to be inhibited and the adrenocortical hypofunction to be secondary. Therefore, the infants with thymomegaly should be separated into a special "risk" group, according to their immunodeficient states, respiratory allergies, acute and chronic adrenocortical deficiency.

11-Hydroxycorticosteroids↗
PubMedDate not supplied

[Potential reserve capabilities of the adenohypophyseal-adrenal cortex system in children with thymus hyperplasia and prospects for treatment].

The potentialities of the adrenocortical system and thymic condition after corticotropin use were studied in young children with thymic hyperplasia combined with pneumonia. The results of the hormonal status studies after zinc-corticotropin suspension load indicate the secondary adrenocortical hypofunction. Corticotropin use within 5 to 10 days in a dose of 1 E/kg body weight intramuscularly is adequate to obtain the thymic involution in thymomegaly.

Adrenal Cortex↗
PubMedDate not supplied

[Model of thymus gland dysfunction].

The thymus dysfunction induced by different doses of lymphocyte-stimulating substance, thymozine, antilymphocyte immunoglobulin and prednisolone effect upon the hormonal-immunologic balance of the hypophyseal-thymus-adrenocortical system, was studied in guinea pigs. It was stated that thymomegalia is accompanied by intensified lymphopoiesis (mainly, owing to T-lymphocytes), somatostimulating hormone and prolactin hypersecretion by adenohypophysis and the adrenocortical glucocorticoid function inhibition. Inverse proportional changes are seen in the thymus hypoplasia. The data obtained may serve as a reliable criterion for physiology and pathology of the thymus and conjugated organs and systems.

11-Hydroxycorticosteroids↗