[Effect of extracorporeal sorption treatment on blood hormone levels].
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Biomedical subjects
Publications and source records attributed to Sh Z Kasymov.
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Alterations of histamine and serotonin levels in blood were found to depend on the duration and degree of the pathological process in the pancreas in acute pancreatitis. The effect of plasmapheresis on the content of biologically active substances in blood at different stages of the development of pancreatonecrosis was studied. It was established that plasmapheresis was an effective means to make the level of histamine and serotonin lower.
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Extracorporeal perfusion of toxic blood via carbonic sorbents is an effective method for correcting severe disturbances of hemostasis. Ultrastructural alterations in hepatic cells were studied in experimental toxic liver injury before and after hemosorption. It was established that after hemosorption the processes of intracellular regeneration were significantly activated in the liver parenchyma. The number of crysts in the mitochondria increased as did the electronic density of the matrix. At the same time the number of lysosomes rose as well. However, in persistent unresolved cholestasis, destructive alterations in the hepatic tissue progressed despite the performance of hemosorption.
Results of the examination of 133 patients show sorption methods of detoxication to be effective means in the complex treatment of hepatic insufficiency. In hepatocerebral insufficiency however resulting from portal cirrhosis better results were obtained after lymphosorption. Hemosorption is indicated in cholemic intoxications as well as after liquidation of the obstruction of the common bile duct.