Experimental evidence of an octahedron nucleus in ZnS tetrapods.
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Crystallization↗
Biomedical subjects
Shaoguang Yang
Publications and source records attributed to Shaoguang Yang.
Controllable assembly of aligned ZnO nanowires/belts arrays.
We describe a simple method to assemble ZnO nanowires/belts into highly ordered arrays. ZnCu(2) alloy was used as the Zn source, which reacted with water vapor to generate ZnO nanocrystals. The reaction was performed in a mild way, which facilitated the easy control of the reaction conditions. By simply controlling the water bath temperature and carrier gas flux in our experiments, we obtained ZnO nanowires/belts aligned to form ordered arrays. The highly ordered nature of the ZnO arrays is suggested to be related both with the polarities of the H(2)O molecule and the ZnO (0001) surface. Photoluminescence (PL) microscopy revealed that the comblike structures had waveguide properties, where green light enhancement was observed at the tips of the branches. The light enhancement property reveals their promising applications as light source arrays.
Journal Article↗
Single crystal SnO2 zigzag nanobelts.
Zigzag SnO2 nanobelts have been synthesized by evaporating tin grain in air. XRD, SEM, and TEM were employed to characterize the prepared samples. SEM images showed large amounts of zigzag nanobelts with periodic morphology. XRD result showed a pure tetragonal SnO2 phase. HRTEM and SAED revealed a single crystal structure with [010] zone axis on the whole zigzag zone. The zigzag structure is deduced to be formed by shifting the growth direction from [101] to [10] or vice versa. Growing nanobelts along different equivalent directions opens a new avenue for the preparation of novel nanostructured materials.
Journal Article↗
Rapid synthesis and visible photoluminescence of ZnS nanobelts.
Belt-like ZnS with visible photoluminescence was synthesized rapidly with Zn and S in the vapor phase.
Journal Article↗
Systemic infusion of FLK1(+) mesenchymal stem cells ameliorate carbon tetrachloride-induced liver fibrosis in mice.
BACKGROUND: Fibrosis is the common end stage of most liver diseases, for which, unfortunately, there is no effective treatment available currently. It has been shown that mesenchymal stem cells (MSCs) from bone marrow (BM) could engraft in the lung after bleomycin exposure and ameliorate its fibrotic effects. This study was designed to evaluate the effect of Flk1 MSCs from murine BM (termed here Flk1 mMSCs) on fibrosis formation induced by carbon tetrachloride (CCl4). METHODS: A CCl(4)-induced hepatic fibrosis model was used. Flk1 mMSCs were systemically infused immediately or 1 week after mice were challenged with CCl(4). Control mice received only saline infusion. Fibrosis index and donor-cell engraftment were assessed 2 or 5 weeks after CCl(4) challenge. RESULTS: We found that Flk1 mMSCs transplantation immediately, but not 1 week after exposure to CCl(4), significantly reduced CCl(4)-induced liver damage and collagen deposition. In addition, levels of hepatic hydroxyproline and serum fibrosis markers in mice receiving immediate Flk1 mMSCs transplantation after CCl(4) challenge were significantly lower compared with those of control mice. More importantly, histologic examination suggested that hepatic damage recovery was much better in these immediately Flk1 mMSCs-treated mice. Immunofluorescence, polymerase chain reaction, and fluorescence in situ hybridization analysis revealed that donor cells engrafted into host liver, had epithelium-like morphology, and expressed albumin, although at low frequency. CONCLUSION: These results suggest that Flk1 mMSCs might initiate endogenous hepatic tissue regeneration, engraft into host liver in response to CCl(4) injury, and ameliorate its fibrogenic effects.
Actins↗
Multipotency of Flk1CD34 progenitors derived from human fetal bone marrow.
We report that a cell population derived from human fetal bone marrow, termed Flk1+CD34- multipotent stem cells, can differentiate not only into osteogenic, adipogenic, and endothelial lineages but also into hepatocyte-like cells and neural and erythroid cells at the single-cell level. We depleted mononuclear cells from fetal bone marrow of CD45+, GlyA+, and CD34+ cells with the use of micromagnetic beads, then cultured them by limiting dilution. Three single colonies were harvested, expanded, and characterized. The clones have been expanded for more than 50 cell doublings, and cell-doubling time was about 30 hours. About 90% cells were in the G(0)/G(1) phase of the cell cycle, and the cells from the single colony maintained Flk1+ and CD34-. Because fetal bone marrow-derived Flk1+CD34-multipotent stem cells have the capacity for self-renewal and multilineage differentiation even after being expanded for more than 50 cell doublings, they may be an ideal source of stem cells for the treatment of inherited or degenerative diseases.
Antigens, CD34↗
Multiorgan engraftment and multilineage differentiation by human fetal bone marrow Flk1+/CD31-/CD34- Progenitors.
We previously reported that Flk1(+)/CD31(-)/CD34(-) cells isolated from human fetal bone marrow can differentiate at the single cell level into endothelial and hematopoietic cells in vitro. Here we report that within this cell population reside cells that can differentiate into the epithelium of liver, lung, gut, as well as the cells of both hematopoietic and endothelial system after primary or secondary transplantation into irradiated nonobese diabetic/severe combined immunodeficient (NOD/SCID) mice. Hence, Flk1(+)/CD31(-)/CD34(-) cells possess remarkable differentiation potential and may thereby provide an alternative to hematopoietic stem cells for transplantation. In addition, our results show this stem cell population effectively accelerated wound healing in NOD/SCID mice and thus holds therapeutic promise for treatment of genetic disorders, organ dysfunction, and tissue repair in humans.
Animals↗