Biomedical subjects

Sharareh Ahmadi

Publications and source records attributed to Sharareh Ahmadi.

3 recordsLinked to original sources

PubMed2005

Pruritic urticarial papules and plaques of pregnancy: current status.

Pruritic urticarial papules and plaques of pregnancy is a common benign dermatosis of pregnancy that was described in 1979 as an intensely pruritic urticarial cutaneous eruption. This is a well-defined clinical entity that mainly occurs in primigravidas in the third trimester, which resolves spontaneously or with delivery and is usually responsive to topical treatments. The aetiology of PUPPP is obscure. Histology is non-specific, but consistently shows mild lymphohistiocytic perivascular inflammatory infiltrate with a variable number of eosinophils. Immunofluorescent studies are negative. The maternal and fetal prognosis are generally unaffected, and the condition is usually responsive to topical corticosteroids and oral antihistamines.

Administration, Cutaneous↗

PubMed2004

Evaluation of the penetration of 5-aminolevulinic acid through basal cell carcinoma: a pilot study.

Aminolevulinic acid (ALA) is a charged, hydrophilic molecule that penetrates poorly through cellular structures. This property has been implicated in the poor clinical response of non-superficial basal cell carcinomas (BCCs) to photodynamic therapy (PDT). Release of ALA hydrochloride from a 20% w/w formulation was found to be incomplete and that approximately 36.8% of the total dose is released during the application period of 4 h. Using scintillation spectroscopy and a precise tissue sectioning protocol, it was demonstrated that depths of penetration of at least 2 mm from the lesion surface had been reached. Using cumulative stratal ALA concentrations, it was found that 10% of the total applied dose permeated into the lesion. In spite of this, comparisons drawn with photodynamic concentrations used in tissue culture work reported elsewhere revealed that estimations of the ALA concentration at 2 mm were sufficient to elicit a possible therapeutic response. Results from this work question the reasons given for poor outcomes of PDT in nodular BCC based solely on depth as a hindering factor.

Aged↗

PubMedDate not supplied

Pyoderma gangrenosum: uncommon presentations.

Pyoderma gangrenosum (PG) is a rare, inflammatory, noninfective, nonneoplastic skin disorder, which is often associated with systemic diseases. These include inflammatory bowel disease, rheumatoid arthritis, paraproteinaemia, or hematologic malignancy, which can be found in up to 50% of patients with some variants of PG. Brunsting et al (Arch Dermatol 1930;22:655-80) first described PG as a disease entity in 5 patients who had painful, enlarging necrotic ulcers with bluish undermined borders surrounded by advancing zones of erythema. Four of these patients had chronic ulcerative colitis. They felt that the condition might be associated with bacterial infection (pyoderma) and considered it as linked to the underlying bowel disease. Although the cause of PG remains obscure, bacterial infection seems to be unrelated to its causation, rendering the term pyoderma redundant. In addition, the number of conditions reported in association with PG has markedly expanded in recent years, showing clearly that this is not solely a cutaneous manifestation of inflammatory bowel disease. The clinical concept of PG has also been broadened, and certain clinical variants of PG have been linked with different types of associated disease seen in these patients.

Adult↗