Biomedical subjects

Sharon Stratton

Publications and source records attributed to Sharon Stratton.

2 recordsLinked to original sources

PubMed2004

Identification of 2,3-diaryl-pyrazolo[1,5-b]pyridazines as potent and selective cyclooxygenase-2 inhibitors.

GW406381 (8), currently undergoing clinical evaluation for the treatment of inflammatory pain is a member of a novel series of 2,3-diaryl-pyrazolo[1,5-b]pyridazine based cyclooxygenase-2 (COX-2) inhibitors, which have been shown to be highly potent and selective. Several examples of the series, in addition to possessing favourable pharmacokinetic profiles and analgesic activity in vivo, have also demonstrated relatively high brain penetration in the rat compared with the clinically available compounds, which may ultimately prove beneficial in the treatment of pain.

Administration, Oral↗

PubMed2003

Recent developments from genetic mouse models of seizures.

The use of genetically altered mice has revolutionised biomedical research into the genetics and neurobiological mechanisms contributing to complex human disorders such as epilepsy. Recent studies using mutant mice have expanded our knowledge of the key roles that abnormalities in synaptic function and formation play in epileptogenesis, and further illustrate just how closely some mouse models resemble human epilepsy. Broader utilisation of epileptic mouse mutants should provide new molecular targets for developing novel anti-epileptic drugs, and also improved means for predicting their efficacy in currently refractory forms of epilepsy.

Animals↗