Biomedical subjects

Shashi

Publications and source records attributed to Shashi.

4 recordsLinked to original sources

PubMed1992

Testicular proteins and DNA in experimental fluorosis.

Experimental fluorosis was induced in young male albino rabbits by exposing them to 0, 5, 10, 20 and 50 mg of NaF via subcutaneous injections for a period of 3-1/2 months. The testicular structural, nuclear and total proteins were significantly depleted in all test groups of animals as compared to the control. There was a significant (p < 0.001) reduction in the testicular DNA after drug administration. The relevance of these results in experimental fluorosis has been discussed.

Animals↗

PubMed1990

Histopathological changes in rabbit testes during experimental fluorosis.

The aim of the study was to evaluate relationship between infertility and the histological structure of the testes following the subcutaneous administration of different doses of sodium fluoride (5, 10, 20 and 50 mg/kg/day), for 100 days, to groups of six male albino rabbits; the six control animals were given 1 cc distilled water/kg b.w./day for the same length of time. Deficient maturation and differentiation of the spermatocytes and an increase in the amount of interstitial tissue were found in the experimental animals. In the higher dosage groups, spermatogenesis stopped and the seminiferous tubules became necrotic. The study thus established the existence of a definite relationship between fluorosis and testicular damage.

Animals↗

PubMed1990

Histopathological changes in rabbit ovary during experimental fluorosis.

Albino rabbits were injected sodium fluoride solutions in the concentration of 5, 10, 20 and 50 mg/kg body weight/day subcutaneously for 100 days. The control rabbits were given 1 cc of distilled water for the same period and sacrificed. The ovary was examined for histopathological changes. Animals in control and 5 mg fluoride treated groups displayed normal follicles with oocytes and interstitial tissue in ovaries. In animals treated with 10 and 20 mg fluoride, ovary exhibited congested oocytes in the follicles, necrosis of follicle cells and interstitial oedema. The degenerative changes were most pronounced in animals treated with 50 mg fluoride, in which complete atrophy of follicles along with oocyte disintegration and marked necrosis of cells accompanied by infiltration of monocytes, lymphocytes and histiocytes in interstitial tissue occurred. The data indicate that the structural alterations in the ovary were more pronounced with the concomitant increase in the dose of fluoride.

Acute Disease↗

PubMed1988

Pulmonary damage caused by fluoride in rabbits during experimental fluorosis.

The effect of fluoride on lung tissue was assessed in rabbits during experimental fluorosis. Sodium fluoride as 5, 10, 20 and 50 mg/kg body weight/day was injected subcutaneously for 100 days into rabbits of both sexes. The control animals were given 1 cc distilled water/kg body weight/day for the same period. Histological studies showed alveolar hemorrhage, necrosis of alveolar epithelium and bronchiolitis, followed by progressive exudation of oedema fluid, congestion, and hyperplasia of alveolar cell nuclei in treated animals. In animals of the 50 mg fluoride group, lung parenchyma had a distorted appearance with loss of alveolar architecture. The structural manifestations in pulmonary tissue were more progressive with the subsequent increase in the dosage of fluoride.

Animals↗