Biomedical subjects

Shenglan Zhang

Publications and source records attributed to Shenglan Zhang.

5 recordsLinked to original sources

PubMed2005

[Oblique sagittal MRI of internal auditory canal applied before cochlear implantation].

OBJECTIVE: To explore practical value of oblique sagittal MRI of internal auditory canal (IAC) before cochlear implantation. METHOD: Fifteen patients(30 ears) with sensorineural hearing loss who prepared to receive cochlear implantation were examined by oblique sagittal MRI (three dimensional T2-weighted fast spin echo) of IAC. RESULT: All patients have successfully completed oblique sagittal magnetic resonance imaging of IAC. The nerves in internal auditory canal were displayed distinctly. Thirteen patients with normal cochlear nerve had CI successfully, while 2 cases didn't receive CI due to abnormality of cochlear nerve. CONCLUSION: Oblique sagittal magnetic resonance imaging of internal auditory canal is a good method for evaluating development of cochlear nerve before cochlear implantation.

Adolescent↗

PubMed2005

[The diagnosis and treatment of facial nerve schwannoma].

OBJECTIVE: To discuss the diagnosis and treatment of facial nerve (FN) schwannomas. METHOD: Two cases of FN schwannoma between 2002 and 2004 in Shanghai Sixth People's Hospital were reviewed. RESULT: Both cases were diagnosed during operation. CONCLUSION: Because of its rarity and various presentations, facial nerve schwannoma is difficult to diagnose. In addition of the common presenting symptoms and physical examination, radiographic studies can delineate the erosion area and the relationship with surrounding tissues. These studies are essential for preoperative planning. The main factors that influence on the recovery of facial nerve function after operation are the preoperative presence of facial nerve deficit and its duration. If the facial nerve deficit lasts over one year, the recovery of facial nerve function will be worse. However, the location and the preoperative grading of facial nerve function has nothing with the recovery.

Adolescent↗

PubMed2004

[CO2 laser assisted stapedotomy with artificial stapes prosthese].

OBJECTIVE: To apply CO2 laser assisted Ugo Fisch stapedotomy with artificial stapes prostheses and to observe its outcome. METHOD: Between October 2001 and June 2003, 24 patients with clinical diagnosis of otosclerosis were performed with CO2 laser assisted Ugo Fisch stapedotomy. Among them 14 were males and 10 were females with a age of 24-65 years (averaged 36.5 years). The preoperative air bone gap of speech frequency is 25.00 to 48.25 dB, with an average of 36.25 dB. Follow-up was done once two months until 6 months. The key techniques are: (1) first disarculate the incudostapedial joint; (2) 0.3 mm or 0.4 mm piston is selected according to the space between horizontal segment of facial nerve and the suprastructure of stapes; (3) fenestrate on the footplate, insert the piston before dealing with stapedial muscle tendon and suprastructure of stapes; (4) deal with stapedial muscle tendon and suprastructure of stapes with CO2 laser. RESULT: A postoperative air bone gap < or = 15 dB is achieved in 23 cases (95.8%), a postoperative air bone gap < or = 10 dB is achieved in 21 cases (87.5%), with a mean of 8.5 dB. The postoperative complication is slight, without sickness and vomit, and 22 patients could walk immediately after surgery. CONCLUSION: CO2 laser assisted stapedotomy is the first choice for treating otosclerosis, which is of significant outcome, high safety and slight postoperative complication.

Adult↗

PubMed2003

The cell-centered database: a database for multiscale structural and protein localization data from light and electron microscopy.

The creation of structured shared data repositories for molecular data in the form of web-accessible databases like GenBank has been a driving force behind the genomic revolution. These resources serve not only to organize and manage molecular data being created by researchers around the globe, but also provide the starting point for data mining operations to uncover interesting information present in the large amount of sequence and structural data. To realize the full impact of the genomic and proteomic efforts of the last decade, similar resources are needed for structural and biochemical complexity in biological systems beyond the molecular level, where proteins and macromolecular complexes are situated within their cellular and tissue environments. In this review, we discuss our efforts in the development of neuroinformatics resources for managing and mining cell level imaging data derived from light and electron microscopy. We describe the main features of our web-accessible database, the Cell Centered Database (CCDB; http://ncmir.ucsd.edu/CCDB/), designed for structural and protein localization information at scales ranging from large expanses of tissue to cellular microdomains with their associated macromolecular constituents. The CCDB was created to make 3D microscopic imaging data available to the scientific community and to serve as a resource for investigating structural and macromolecular complexity of cells and tissues, particularly in the rodent nervous system.

Brain↗

PubMed2002

[Early complications of surgery for chronic suppurative otitis media].

OBJECTIVE: To explore early post-operative complications following surgery for chronic suppurative otitis media. METHOD: From Jan 1992 to July 2000, 291 cases of chronic suppurative otitis media have been treated in our department. 79 cases underwent myringoplasty, 82 cases tympanoplasty, 88 cases modified radical mastoidectomy and 42 cases radical mastoidectomy. RESULT: Facial nerve palsies occurred in 3 cases (1.03%), bone conduction threshold elevation occurred in 13 cases (4.47%), wound infection occurred in 11 cases (3.78%), 7 patients (2.41%) reported symptoms related with chorda tympani trauma, symptoms of jaw discomfort were reported by 7 patients (2.41%) and imbalance or vertigo by 13 patients(4.47%). CONCLUSION: The incidence of early complications of surgery for chronic suppurative otitis media in this report was similar to previous reports.

Adolescent↗