Biomedical subjects

Shiva Das

Publications and source records attributed to Shiva Das.

3 recordsLinked to original sources

PubMed2006

Physics and imaging for targeting of oligometastases.

Oligometastases refer to metastases that are limited in number and location and are amenable to regional treatment. The majority of these metastases appear in the brain, lung, liver, and bone. Although the focus of interest in the past within radiation oncology has been on the treatment of intracranial metastases, there has been growing interest in extracranial sites such as the liver and lung. This is largely because of the rapid development of targeting techniques for oligometastases such as intensity-modulated and image-guided radiation therapy, which has made it possible to deliver single or a few fractions of high-dose radiation treatments, highly conformal to the target. The clinical decision to use radiation to treat oligometastases is based on both radiobiological and physics considerations. The radiobiological considerations involve improvement of treatment schema for time, dose, and volume. Areas of interests are hypofractionation, tumor and normal tissue tolerance, and hypoxia. The physics considerations for oligometastases treatment are focused mainly on ensuring treatment accuracy and precision. This article discusses the physics and imaging aspects involved in each step of the radiation treatment process for oligometastases, including target definition, treatment simulation, treatment planning, pretreatment target localization, radiation delivery, treatment verification, and treatment evaluation.

Dose Fractionation, Radiation↗

PubMed2004

Relationship between the generalized equivalent uniform dose formulation and the Poisson statistics-based tumor control probability model.

The generalized equivalent uniform dose (GEUD) model uses a power-law formalism, where the outcome is related to the dose via a power law. We herein investigate the mathematical compatibility between this GEUD model and the Poisson statistics based tumor control probability (TCP) model. The GEUD and TCP formulations are combined and subjected to a compatibility constraint equation. This compatibility constraint equates tumor control probability from the original heterogeneous target dose distribution to that from the homogeneous dose from the GEUD formalism. It is shown that this constraint equation possesses a unique, analytical closed-form solution which relates radiation dose to the tumor cell survival fraction. It is further demonstrated that, when there is no positive threshold or finite critical dose in the tumor response to radiation, this relationship is not bounded within the realistic cell survival limits of 0%-100%. Thus, the GEUD and TCP formalisms are, in general, mathematically inconsistent. However, when a threshold dose or finite critical dose exists in the tumor response to radiation, there is a unique mathematical solution for the tumor cell survival fraction that allows the GEUD and TCP formalisms to coexist, provided that all portions of the tumor are confined within certain specific dose ranges.

Algorithms↗

PubMed2003

Beam orientation selection for intensity-modulated radiation therapy based on target equivalent uniform dose maximization.

PURPOSE: To develop an automated beam-orientation selection procedure for intensity-modulated radiotherapy (IMRT), and to determine if a small number of beams picked by this automated procedure can yield results comparable to a large number of manually placed orientations. METHODS AND MATERIALS: The automated beam selection procedure maximizes an unconstrained objective function composed of target equivalent uniform dose (EUD) and critical structure dose-volume histogram (DVH) constraints. Beam orientations are selected from a large feasible set of directions through a series of alternating fluence optimization and orientation alteration steps, until convergence to a stable orientation set. The fluence optimization step adjusts fluences to maximize the objective function. The orientation alteration step substitutes beams in the orientation set currently under consideration with beams of the parent set in the immediate angular vicinity; the altered orientation set is deemed current if it produces a higher objective function value in the fluence optimization step. RESULTS AND CONCLUSIONS: It is demonstrated, for prostate IMRT planning, that a modest number of appropriately selected beam orientations (3 or 5) can provide dose distributions as satisfactory as those produced by a large number of unselected equispaced orientations. Such selected beam orientations can reduce overall treatment time, thus making IMRT more clinically practical.

Algorithms↗