Biomedical subjects

Shu-Ping Huang

Publications and source records attributed to Shu-Ping Huang.

7 recordsLinked to original sources

PubMed2006

Theoretical study of two-photon absorption in donor-acceptor chromophores tetraalkylammonium halide/carbon tetrabromide.

Two-photon absorption properties of a series of donor-acceptor chromophores of tetraalkylammonium halide/carbon tetrabromide ([NR4h.CBr4], h = Cl, Br, I; R = Me, Et, Pr) complexes are investigated in terms of the calculated results by the time-dependent density functional theory (TDDFT) technique combined with the sum-over-states (SOS) method. The modeling two-photon absorption spectra show that these charge-transfer complexes have large two-photon absorption (TPA) cross sections and the [NEt4I.CBr4] has the largest TPA cross section delta with the value of 5.0 x 10(-45) cm4 s photon(-1). The maximum values of delta increase with increasing separations between the donor/acceptor in the order Cl...Br < Br...Br < I...Br for [NEt4h.CBr4] complexes; however, the TPA cross sections delta vary slightly as the size of the alkyl group increases from methyl to propyl for the bromide as a donor, and the maximum wavelength of the TPA peak lambdamax indicates a bathochromic shift. The charge transfers from the halide anion to the carbon tetrabromide make a significant contribution to the excited states, and the donor-acceptor charge transfer plays an important role in the TPA activity, whereas changes in size of alkyl group do not make a substantial contribution to TPA.

Computer Simulation↗

PubMed2006

Se2(B2O7): a new type of second-order NLO material.

Exploration on the compounds in the selenite-borate system led to the discovery of a new second-order NLO material, Se2B2O7, with a SHG efficiency of about 2.2 times that of KDP (KH2PO4). Its structure features a 3D network with helical tunnels, and it is transparent in the UV and visible region. The compound is a wide band gap semiconductor.

Journal Article↗

PubMed2006

Synthesis, characterization and properties of chromium(III) complex [Cr(SA)(en)2]Cl.2H2O.

The reaction of chromium(III) chloride, salicylic acid (SA) and ethylenediamine (en) led to the formation of chromium complex [Cr(SA)(en)(2)]Clx2H(2)O(1). The crystal structure belongs to monoclinic system with the space group P2(1), R(1)=0.0358. In this compound, Cr(III) atom is six-coordinated in octahedral coordination geometry by one phenolic hydroxyl oxygen, one carboxylate oxygen from the salicylic acid and four nitrogen atoms from two ethylenediamine molecules, respectively. The transfer manners of Cr(III) from the title compound to the low-molecular-mass chelator, ethylenediamine-N,N,N',N'-tetraacetic acid (EDTA) and the iron-binding protein apoovotransferrin (apoOTf) were followed by a combination of UV-visible (UV-Vis) and fluorescence spectra in 0.01M Hepes at pH 7.4. The results show that Cr(III) can be transferred from the complex to apoovotransferrin with the retention of the salicylate acted as a synergistic anion.

Chlorides↗

PubMed2005

Preparation and characterization of inclusion complexes of pefloxacin mesylate with three kinds of cyclodextrins.

The ability of alpha-cyclodextrin, beta-cyclodextrin and hydroxypropyl-beta-cyclodextrin (alpha-CD, beta-CD and HP-beta-CD) to break pefloxacin mesylate (PM) aggregates by forming inclusion complexes has been studied using 1H NMR (nuclear magnetic resonance spectroscopy), 13C NMR and fluorescence spectra. The inclusion constants are determined to compare the corresponding inclusion capacity. Solid-inclusion complexes of PM with CDs are synthesized by coprecipitation method, and all the inclusion ratios are found to be 1:1. Additionally, spatial characterization of complexes has been proposed based on two-dimensional nuclear magnetic resonance technique (2D NMR) and spatial conformation is also investigated to propose two possible models between PM and CDs.

2-Hydroxypropyl-beta-cyclodextrin↗

PubMed2004

(1R,2R)-(-)-Bis[mu4-1-[[1,1-dimethyl-2-(trimethylsilyl)amidino]amino]-2-([1,1-dimethyl-2-[1,1-dimethyl-2-(trimethylsilyl)amidino]amidino]amino)cyclohexane]tetralithium(I).

The title compound, [Li(4)(C(21)H(46)N(8)Si(2))(2)], has been prepared and its structure determined. The whole molecule can be regarded as a molecular cage made up of the central eight-membered ring and six contiguous rings of three types. As the first example of a bridged amidinate-dicyanamide framework, this noteworthy structure and its electronic features are presented.

Journal Article↗

PubMed2004

[Benzylbis(dimethylamino)methylsilyl-kappa2C,N](N,N,N',N'-tetramethylethylenediamine-kappa2N,N)lithium(I).

The title compound, [Li(C12H21NSi)(C6H16N2)], is an intermediate in the synthesis of the corresponding organometallic compounds. The molecule has an unusual C-Si-N-Li four-membered heterocycle which adopts a folded conformation, with the coordination around the Li, N, C and Si atoms being distorted tetrahedral. Its structure is strongly supported by 1H NMR, 13C NMR and 13C-1H correlation spectra. The compound has potential for application in the synthesis of other novel organometallic compounds.

Journal Article↗

PubMed2004

Preparation and study on the solid inclusion complex of sparfloxacin with beta-cyclodextrin.

The interaction of sparfloxacin with beta-cyclodextrin (beta-CD) has been studied by several analytical techniques, including 1H-NMR, 13C-NMR, fluorescence spectroscopy, infrared spectroscopy, thermal analysis, and scanning electron microscope. In this paper, solid inclusion complex of sparfloxacin with beta-CD was synthesized by the coprecipitation method. In addition, the characterization of the inclusion complex has been proved by fluorimetry, Infrared, differential scanning calorimetry and 1D, 2D NMR. The experimental results confirmed the existence of 1:1 inclusion complex of sparfloxacin with beta-CD. The formation constant of complex was determined by fluorescence method and 1H-NMR. Spacial configuration of complex has been proposed on 2D NMR techniques.

Calorimetry, Differential Scanning↗