Biomedical subjects

Si-Hyun Park

Publications and source records attributed to Si-Hyun Park.

4 recordsLinked to original sources

PubMed2006

Foreign body removal and immediate nasal reconstruction with superficial temporal fascia.

For nasal augmentation, various materials have been used for many years. The injection of foreign body has been carried on, although it is performed mostly by laymen. Because many complications arise after augmentation rhinoplasty by foreign body injection, secondary correction has been needed. These complications have included headaches, swelling, redness, palpable mass, skin discoloration, telangiectasia and fear of cancer. The authors treated 10 patients who had undergone injection of foreign body to the nose. After the foreign body was removed, we immediately reconstructed nasal deformity by silicone implant wrapping with superficial temporal fascia. This method has many advantages including easy contouring of nasal shape and fixation, absence of foreign body reaction, reduced inflammatory reaction, no or minimal concerns regarding the migration or extrusion of the implants, and nonvisible donor scar. The mean follow-up period was 8 months, and no complications occurred. The authors conclude that nasal deformity can be successfully reconstructed immediately using silicone implant wrapping with superficial temporal fascia after foreign body is removed from the nose. In the authors' experience, this procedure has improved aesthetic appearance and met patients' expectations.

Adult↗

PubMed2006

Reduction malarplasty by 3-mm percutaneous osteotomy.

Oriental people usually have a wide midface and a prominent malar curve. The zygomatic bone forms the prominence of the cheek, and it is the most important part in determining the ideal oval shape of the face on the frontal view and the character of the oblique profile. Therefore, zygoma contouring is commonly performed. Women with a prominent zygoma have an inferiority complex associated with unattractive facial features resembling aged, melancholic, and strong characters in oriental culture. Zygoma is the highlighted area of the midface and a major determinant of midfacial shape, but harmony with the adjacent area is very important. Therefore, to obtain the optimal outcome of reduction malarplasty, various ancillary procedures must be performed simultaneously. The authors performed 30 reduction malarplasties during the past 2 years. The amount of bone to be removed was determined by the preoperative interview, physical examination, and x-rays. Intraoral incisions provided access to the zygomatic body and lateral orbital rim. After the L-shaped osteotomy, two parallel vertical and transverse osteotomies in the medial part of the zygomatic body, the midsegment was removed. The posterior portion of the zygomatic arch was approached through a stab incision in the preauricular area. A 3-mm osteotome was used. After completion of the osteotomy, the movable zygomatic complex was reduced medially and superiorly, then fixed with miniplates and screws on the zygmaticomaxillary buttress. The combined operations with reduction malarplasty were as follows: reduction of the mandibular angle in 15 cases, rhinoplasty in 14 cases, and double-fold operation in 11 cases. The follow-up period was 2 months to 2 years, and all the patients were satisfied with the results. In conclusion, this method is a very simple, easy, and safe method that reduces the operating time to 1 h and minimizes postoperative edema and swelling. Consequently, recovery time is relatively short, and no conspicuous scars in the preauricular area are left. The authors also performed many ancillary procedures, thereby obtaining optimal satisfaction with their results, including decreased facial width and superior mobilization of the prominent area. They were able to prevent postoperative cheek drooping, and to give the patients a more youthful, charming look.

Adult↗

PubMed2006

Synthesis and evaluation of antitumor activity of novel 1,4-naphthoquinone derivatives (IV).

1,4-Naphthoquinones are widely distributed in nature and many clinically important antitumor drugs containing a quinone moiety, such as anthracyclines, mitoxantrones and saintopin, show excellent anticancer activity. In this study, 2- or 6-substituted 5,8-dimethoxy-1,4-naphthoquinone (DMNQ) and 5,8-dihydroxy-1,4-naphthoquinone (DHNQ) derivatives were synthesized, and their cytotoxic activity against L1210 and P388 cancer cells was examined. Their antitumor activity was also assessed in mice bearing S-180 cells in the peritoneal cavity. In comparison with the DMNQ derivatives, the DHNQ derivatives exhibited more potent bioactivities than the DMNQ derivatives against both L1210 and P388 cells in vitro and S-180 cells in vivo. The ED50 values of the DHNQ derivatives against P388 cells were in the range of 0.18-1.81 microg/mL whereas those of the DMNQ derivatives were in the range of 0.26-40.41 microg/mL. The T/C (%) values of the DHNQ derivatives, 8, 17, 18, 19, and 20, were found to be comparable to or even better than that of adriamycin. It was also observed that the 2-substituted derivatives (8, 19, 20) showed better antitumor activity than the 6-substituted derivatives (7, 17, 18) in the mice bearing S-180 cells in the peritoneal cavity.

Animals↗

PubMed2004

Nasal tip plasty using various techniques in rhinoplasty.

Rhinoplasty is one of the most common aesthetic surgical procedures in Korea today. However, simple augmentation rhinoplasty results often failed to satisfy the high expectations of patients. As a result, many procedures have been developed to improve the appearance of the nasal tip and nasal projection. However, the characteristics of Korean nasal tips including the bulbous appearance (attributable to the thickness of the skin), flared nostrils, and restriction of the nasal tip attributable to an underdeveloped medical crus of the alar cartilage and a short columella have made such procedures difficult. Currently, most plastic surgeons perform rhinoplasty simultaneously with various nasal tip plasty techniques to improve the surgical results. An important part of an aesthetically pleasing result is to ensure an adequate nasal tip positioned slightly higher than the proper dorsum, with the two tip defining points in close proximity to each other, giving the nose a triangular shape from the caudal view. From June 2002 to November 2003, the authors performed rhinoplasty with simultaneous nasal tip plasty using various techniques according to the tip status of 55 patients (25 deviated noses, 9 broad noses, 15 low noses, and 6 secondary cleft lip and nose deformities). The surgery included realignment of alar cartilage by resection and suture, fibroareolar and subcutaneous tissue resection, tip graft, and columellar strut. The postoperative results over an average period of 10 months were entirely satisfactory. There were no patient complaints, nor complications resulting from the procedures. Good nasal tip projection, natural columellar appearance, and improvement of the nasolabial angle were achieved for most patients. In conclusion, rhinoplasty with simultaneous nasal tip plasty, achieved by a variety of techniques according to patients' tip status, is an effective method for improving the appearance of the nose and satisfying the desires of the patients.

Adult↗