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Biomedical subjects

Sid Gilman

Publications and source records attributed to Sid Gilman.

28 records · Page 2Linked to original sources
PubMed2004

Denny-Brown, Boston City Hospital, and the history of American neurology.

Harvard University's Neurological Unit at Boston City Hospital (BCH) became the premier center for neurological training in the United States during the middle part of the 20th century. During part of this period (1939-1967), it was directed by Derek Denny-Brown, who had been recruited from England by Harvard president James Conant. The training program that Denny-Brown initiated at BCH emphasized neurology as a medical specialty, independent of psychiatry and neurosurgery. This program, which reflected Denny-Brown's British training, was remarkably effective and served as a model for rest of the country.

Biomedical Research↗
PubMed2003

Using extirpations to understand the human motor cortex: Horsley, Foerster, and Bucy.

During the last part of the 19th century and through the middle of the 20th century, surgeons sometimes extirpated parts of the human motor cortex to control abnormal involuntary movements. This procedure can be traced directly to Victor Horsley, who pioneered the first successful surgery of this type in 1886. Although many neurosurgeons followed Horsley's lead in performing this procedure, few used their results, as he did, to formulate concepts on the role of the motor cortex in movement control. Otfrid Foerster and Paul Bucy were the principal exceptions. We reviewed the surgical procedures these 3 notable neurosurgeons performed on the motor cortex and the hypotheses they subsequently developed on the functions of the motor cortex. We also evaluated these writings relative to contemporary views of motor cortex function.

England↗
PubMed2003

Feud and fable: the Sherrington-Horsley polemic and the delayed publication.

In the February and March 1894 pages of The Lancet and in private letters, Charles Sherrington and Victor Horsley exchanged angry accusations pertaining to primacy of research on the course of the pyramidal fiber tract as determined from studies in monkeys. The polemics appear not to have ended in a manner satisfactory to either one. Moreover, the dispute allegedly led to a remarkable delay in publication of one of Sherrington's major contributions, which pertained to the localization of the motor cortex in apes that was published in 1917. Here we examine the argument in detail including the comments of an intermediary, Professor Rubert Boyce. We also examine the evidence for the supposed delay in publication, and conclude that the account of the delay originated in John Fulton's 1952 obituary of Sherrington, and is not true. We suggest it has become a fable that should no longer be repeated.

Animals↗
PubMed2002

Denny-Brown, Wilson's disease, and BAL (British antilewisite [2,3-dimercaptopropanol]).

In 1951 Denny-Brown and Porter described the successful treatment of Wilson's disease using the chelating agent British antilewisite. The presentation of their results both at meetings and in print changed the traditional view of neurology from a descriptive to an interventional discipline using treatments based on the underlying biochemical disorder. The authors review the importance of these reports and provide edited digital versions of the films Denny-Brown made of the five patients described in the initial reports.

Dimercaprol↗
PubMed2002

Hereditary neuronal intranuclear inclusion disease with autonomic failure and cerebellar degeneration.

BACKGROUND: Neuronal intranuclear inclusion disease (NIID), a multiple-system degeneration, occurs usually as a sporadic disorder with onset in childhood. The disease has been found in monozygotic twins and in siblings. In 2 previously described families, the disorder has affected 2 generations. OBJECTIVE: To investigate the clinical, anatomical, and electrophysiological characteristics of NIID that affect the central nervous system and the central and peripheral components of the autonomic nervous system in 2 successive generations of a family. DESIGN: Case report. SETTING: Tertiary care hospital. PATIENTS: A 53-year old woman and her sons, aged 28 and 25 years. Symptoms began in childhood in 2 of the 3 cases, and consisted of urinary and fecal incontinence, erectile dysfunction in the men, and recurrent orthostatic hypotension. METHODS: We used results of clinical neurological evaluations; cranial magnetic resonance imaging; skeletal muscle and sphincter electromyography (EMG); peripheral nerve conduction and bulbocavernosus reflex studies; autonomic function tests; brainstem, visual, somatosensory, and motor evoked potentials; auditory and vestibular testing; metabolic and molecular genetic testing; and muscle and rectal biopsy with immunohistochemistry. RESULTS: We found variable degrees of ocular dysmetria in 2 cases, ataxic dysarthria and limb ataxia in 1, and hyperreflexia in 2. Magnetic resonance imaging revealed cerebellar atrophy in all 3 cases and diffuse cerebral cortical atrophy in 1. Results of peripheral nerve conduction studies were normal. Sphincter EMG findings were abnormal in 2 of the 3 cases, and results of autonomic function tests were abnormal in the same 2. The EMG in 1 case revealed a chronic neurogenic pattern in the distal limb muscles. Metabolic and molecular genetic testing revealed no abnormal findings. Results of the muscle biopsy were negative, but results of the rectal biopsy revealed eosinophilic ubiquitinated intranuclear inclusions in neurons. CONCLUSION: Transmission of NIID in 2 generations presenting with autonomic failure and cerebellar ataxia was hereditary.

Adult↗
PubMed2002

Horsley was the first to use electrical stimulation of the human cerebral cortex intraoperatively.

Fedor Krause has previously been credited with being the first surgeon to use electrical stimulation to define epileptic foci in the human cerebral cortex before extirpation. We provide evidence indicating that Krause was probably preceded by Horsley, and Bidwell and Sherrington in England, and by Keen in the United States. Sir Victor Horsley apparently first used electrical stimulation diagnostically in 1884 and slightly later (1886) to define epileptic foci.

Brain Diseases↗
PubMed2002

Relationship between neuropsychological and emotional functioning in severe chronic alcoholism.

Previous studies of patients with severe chronic alcoholism have shown a high prevalence of emotional distress such as anxiety and depression, and neuropsychological impairments such as executive deficits, but few have examined the relationship between these disorders. We addressed this issue in 51 abstinent patients with histories of severe chronic alcoholism utilizing the Minnesota Multiphasic Personality Inventory (MMPI) and the Halstead-Reitan Neuropsychological Test Battery (HRNTB). Applying factor analysis to the MMPI clinical and validity scales, we derived four dimensions accounting for 78% of the available variance. We found that Factor 1, which loaded on most clinical scales of the MMPI, was significantly correlated (p <.01) with performance on the Halstead Category Test (HCT), a measure of executive functioning. Further, group analysis with MANOVA using HCT (impaired and nonimpaired) as the independent variable revealed a significant main effect for Factor 1 (p <.004), which was maintained and strengthened when age and education were controlled as covariates (p <.001). The results suggest a relationship between emotional distress and executive functioning as measured by the HCT, reflecting differing facets of frontal lobe dysfunction common to cognitive and affective domains in patients with severe chronic alcoholism.

Adult↗
PubMed2002

Motor cortex extirpation (1886-1950): the influence of Sir Victor Horsley.

OBJECTIVE: To delineate Sir Victor Horsley's influence on neurosurgeons who subsequently reported (through 1950) on the effects of motor cortex extirpation surgery. METHODS: We used the available literature to divide Horsley's influence into five categories, i.e., direct trainee, via a trainee or colleague, via personal contact and publications, via publications only, and no evidence of influence. RESULTS: Of 15 later neurosurgeons who reported results through 1950, the numbers corresponding to the five categories were 1, 6, 2, 3, and 3, respectively. CONCLUSION: Horsley's influence on neurosurgeons who performed motor cortex extirpation surgery was primarily indirect, with most influence occurring via trainees of his students or colleagues. Although indirectly associated with Horsley, Paul Bucy was his truest disciple.

History, 20th Century↗