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Biomedical subjects

Siegfried J Pöppl

Publications and source records attributed to Siegfried J Pöppl.

3 recordsLinked to original sources

Artificial neural network-based classification to screen for dysphonia using psychoacoustic scaling of acoustic voice features.

SUMMARY: For diagnosis and classification of dysphonia, voice specialists can choose from an array of diagnostic tools like perceptual tests or acoustic voice analysis. These methods have in common that they require a high level of specialized training and experience, and therefore are mostly reserved to specialized centers. We aimed at developing an acoustic voice analysis system that could be used as a screening device to monitor, document, and diagnose voice problems that are also encountered by non-voice specialists, such as anesthesiologists, head and neck surgeons, and general surgeons before surgery of the thyroid gland and the upper thoracic aperture. An acoustical feature extraction paradigm that focused on jitter, shimmer, standard deviation of fundamental frequency, and the glottal-to-noise excitation ratio was used to reanalyse 120 voice samples previously analyzed by Schönweiler et al (A Novel Approach to Acoustical Voice Analysis Using Artificial Neural Networks. JARO. 2000:1;270-282). An improved artificial neural network (ANN) was used for classification. Building on this preliminary work, we modified the mathematical algorithm to further improve classification accuracy. Eighty percent of all voice samples could be classified correctly as either healthy or hoarse (sensitivity: 63.0%; specificity: 93.9%; area under the curve: 0.854). The adaptation of the ANN-voice analysis system for mobile use may facilitate its use and acceptance by non-voice specialists for the discovery and documentation of preexisting voice disorders, and may thereby lead to a timely initiation of further diagnosis and therapy by voice specialists.

Diagnosis, Differential↗

The 'subsequent artificial neural network' (SANN) approach might bring more classificatory power to ANN-based DNA microarray analyses.

MOTIVATION: Human decisions often proceed in two steps. Initially those most preferred are chosen followed by a subsequent choice of these preferences. Applying one artificial neural network (ANN), a classification is limited to the preselection process. The final categorization is only possible by a subsequent ANN that distinguishes the pre-chosen classes. Existing strategies using coupled ANNs are discussed and a new approach particularly suited for multiclass classification problems is introduced ('Subsequent ANN', SANN). RESULTS: Evaluating a simulated data base comprising 3 classes, classification results of SANN were obviously superior to those achieved by ANN. To evaluate a real-world data base the microarray benchmark GCM (14 classes) was chosen. The ANN results reached 72%, comparable to previous results. Using SANN, up to 81% of the tumors were correctly classified. AVAILABILITY: Programs used in this work and numerical results are available upon request.

Algorithms↗

A novel method for diagnosing chronic rhinosinusitis based on an electronic nose.

The nasal out-breath of persons with chronic nasal and/or paranasal infections may have characteristic strange odors, which in our experience are in most cases related to bacterial and/or fungal infections of the sinuses. The objective of the present study was to examine nasal out-breath samples from patients with chronic rhinosinusitis (CRS) (with or without polyposis) and healthy control volunteers using the electronic-nose (EN) technology. We developed a simple technique for collecting samples of nasal out-breath in disposable sterile plastic sacks with a tight closing seal. The principal component analysis correctly classified all individual EN patterns for CRS patients and misclassified 2 samples from the healthy controls (80.0% successful classification rate). The artificial neural network analysis correctly classified 60.0% of the patterns of both groups. We believe that the use of methodologies based on EN technology, combined with conventional clinical examinations, may improve the diagnosis of chronic rhinosinusitis.

Adult↗