Silvio Caldas Neto | PubMed Health

PubMed2006

Otomicroscopic and histologic findings of induced myringosclerosis in rats: a critical study of an experimental model.

UNLABELLED: Myringosclerosis is characterized by hyaline changes of the lamina propria of the tympanic membrane. Experimental studies have used otomicroscopy or histology to evaluate myringosclerosis in animals, but they do not correlate precisely these two methods. AIM: The present study evaluates the accuracy of otomicroscopy in the diagnosis of myringosclerosis in rats. STUDY DESIGN: Experimental. MATERIAL AND METHOD: Myringosclerosis was induced by transtympanic inoculation of Streptococcus pneumoniae in 25 Wistar rats, which were examined weekly through otomicroscopy and sacrificed after eight weeks for histologic study of their tympanic membranes. RESULTS: From the comparison of the otomicroscopic data in relation to the histologic findings, we could observe sensibility of 80% and specificity of 75% for the otomicroscopy. CONCLUSION: Considering the results in this study, otomicroscopy did not represent a good method to evaluate myringosclerosis in this experimental model.

Animals↗

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Postgraduate pariah.

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Brazil↗

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Efficacy of functional endoscopic sinus surgery for symptoms in chronic rhinosinusitis with or without polyposis.

UNLABELLED: Functional endoscopic sinus surgery is the preferred treatment for chronic rhinosinusitis currently. Success on symptoms relief and quality of life improvement are the study leading objectives. STUDY DESIGN: retrospective clinical trial. METHODS: Questionnaires were given to the patients referred to Hospital das Clinicas-UFPE to chronic rhinosinusitis (CRS) functional endoscopic sinus intervention during 2003-2004. Symptoms outcome before and after surgery were compared and analyzed using a five-point-ranking scale. RESULTS: Twenty-four patients answered the questions. Eleven patients had CRS and 13 had CRS associated with nasal polypos. Quality of life was restricted by CRS in everyone, with a good improvement in 54,2% cases. All patients could recommend functional endoscopic sinus surgery to someone with same nasal problems and only 3 would not get surgery again. The best symptoms relief results were: nasal obstruction (83,3%), cacosmia/halitosis (80%), hyposmia/anosmia (63,15%), headache (62%). Patients with polyps achieved better symptomatic response than patients with only CRS. CONCLUSIONS: The leading symptoms were improved by functional endoscopic sinus surgery but not so much we expect. Allergic rhinitis presenting, not using nasal spray, poor ambient control influenced this result. Polyps patient achieved better symptoms outcome and quality of life responses on the most of symptoms than CRS patients.

Adult↗