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Biomedical subjects

Simon Taylor

Publications and source records attributed to Simon Taylor.

7 recordsLinked to original sources
PubMed2006

Minimum foot clearance during walking: strategies for the minimisation of trip-related falls.

This paper models minimum foot clearance (MFC) data during steady-state gait to investigate how the various descriptive statistics of the MFC distribution differ in healthy young and elderly females. A minimum of 20min of treadmill walking was analysed for 17 young and 16 elderly females using a Peak Motus motion analysis system. The results indicated that none of the 33 participants' MFC data sets were Normally distributed. The deviation from a Normal distribution was systematic (always skewness>0 and kurtosis>0). Skewness and kurtosis in MFC data was highly correlated (young: r=0.60, p=0.01; elderly: r=0.95, p<0.01). MFC descriptive statistics provide useful information about basic strategies used by individuals to minimize the likelihood of tripping. Possible strategies to minimize tripping include: (a) increasing MFC height central tendency, (b) reducing MFC variability, and/or (c) increasing right skewness. A low median MFC was often associated with a low IQR or high skewness to compensate. Further research is required to establish how, or if at all, these strategies are modified in populations that are more at risk of falling.

Accidental Falls↗
PubMed2005

Modification of the ultrafiltration technique to overcome solubility and non-specific binding challenges associated with the measurement of plasma protein binding of corticosteroids.

Plasma protein binding (PPB) methodology suitable for application in the lead optimisation of a corticosteroid series known to demonstrate non-specific binding (NSB) and poor solubility has been established. The method involved a modification to standard ultrafiltration (UF) techniques. In parallel with each experimental plasma sample, a control plasma sample was also processed by ultrafiltration. The retentate from experimental and control plasma samples were mixed back into the filtrate of the partner sample. The resulting regenerated plasma samples, one representing the experimental filtrate and one representing the experimental retentate, were then analysed by LC/MS/MS. Varying degrees of NSB were demonstrated with a number of corticosteroids, and this effect was eliminated using the modified method. Validation using a panel of established corticosteroids showed good agreement with published PPB figures. The published PPB figure for fluticasone propionate (FP) was, however, found to be an underestimate, and this was subsequently confirmed, at clinically relevant plasma concentrations, to be 99.3%. The modified method was particularly suited to lead optimisation because it provided samples in a consistent matrix compatible with standard high throughput LC/MS/MS analysis.

Adrenal Cortex Hormones↗