Biomedical subjects

Snezana Filipović

Publications and source records attributed to Snezana Filipović.

5 recordsLinked to original sources

PubMed2005

[Chronic sarcoidosis].

INTRODUCTION: According to available literature data, chronic pulmonary and extrapulmonary sarcoidosis occurs in 10-30% of all sarcoidosis patients. Unpredictable course of the disease is a great challenge for scientists and researchers. Clinical and biological parameters for evaluation and prediction of the course of the disease are still the topic of different scientific investigations all over the world. According to an American case control study on sarcoidosis, unique diagnostic criteria have been established in order to simplify the diagnosis of sarcoidosis. The aim of this study was to present the morbidity and the clinical course of sarcoidosis in our patients. MATERIALS AND METHODS: We analyzed 370 sarcoidosis patients and confirmed the diagnosis of sarcoidosis by biopsy of the suspected granuloma, and by excluding any other possible cause of granulomatous inflammation. In our analyzed patients with sarcoidosis, chronic form was diagnosed in about 30%. An extremly unpredictable, chronic form of the disease was established in patients with extrapulmonary localisations (heart, CNS, liver and bones). CONCLUSION: Follow-up criteria and control examinations of sarcoidosis patients are suggested as well.

Chronic Disease↗

PubMed2005

[Sarcoidosis and diabetes: therapeutic aspects].

FIRST CASE: A 45-year-old female patient with diabetes was on corticosteroid therapy for a year due to pulmonary sarcoidosis. During the last six years she was treated with oral antidiabetic drugs, but during the last couple of months, she required insulin therapy due to impaired glycoregulation. After corticosteroid therapy was discontinued, glycoregulation improved and insulin therapy was discontinued as well. SECOND CASE: a 32-year-old male patient was on prednisolone therapy due to pulmonary and extrapulmonary sarcoidosis. A few weeks later diabetes mellitus (de novo) was established. During the treatment of sarcoidosis with corticosteroids, short-term insulin therapy was due to impaired glycoregulation. Insulin therapy has improved the glycoregulation. DISCUSSION: There is no certain evidence about the incidence of diabetes mellitus under the influence of corticosteroids, due to increase of hepatic glucose production, insulin resistance and exhaustion of pancreatic beta-cells because of stimulated endogenous secretion. During treatment of sarcoidosis, corticosteroid therapy may cause deterioration of glycoregulation and occurrence of clinically manifested diabetes mellitus in patients with impaired glycose tolerance or predisposition to diabetes. CONCLUSION: Diabetic patients with sarcoidosis who need corticosteroid therapy, should control glycoregulation Patients with sorcoidosis, treated with corticosteroid therapy need regular control in order to diagnose early diabetes.

Adult↗

PubMed2005

[Application of measuring instruments--quality of life questionnaires in patients with chronic sarcoidosis].

INTRODUCTION: Health-related quality of life in interstitial lung diseases, especially in sarcoidosis, has hardly received appropriate attention in clinical studies due to lack of validated methods of measurement. Until now, in patients with sarcoidosis and interstitial lung diseases, several generic and respiratory specific quality-of-life instruments were used in order to discover the most valid and reliable quality-of-life instrument. Sarcoidosis is a multi-system disease that affects quality of life in many different ways. MATERIAL AND METHODS: In this study the Sarcoidosis Health Questionnaire was used to evaluate the quality of life in sarcoidosis patients. 89 biopsy positive sarcoidosis patients were analyzed (16 male, 73 female); their mean age 46.15 +/- 11.11 years. 34 (39%) patients presented with acute sarcoidosis, 53 (61%) with chronic sarcoidosis and 46 patients (51.7%) had extrapulmonary disease. In regard to treatment, 51 (57%) patients were treated with corticosteroids 18 (20%) with methotrexate and in 20 (23%) spontaneous remission was reported. All analyses were performed using the Statistical Package for Social Science Software: A probability value less than 0.01 considered being statistically significant. RESULTS: Statistically significant correlation was found between the sarcoidosis health questionnaire scores and chronic sarcoidosis. daily 0.001, emotional 0.014 and total 0.01. In regard to treatment, significant difference between groups was found in the domain of physical (sig 0.006) emotional (sign 0.005) and total (sign 0.001) scores. CONCLUSION: The first sarcoidosis specific questionnaire shows perfect correlation with the possible clinical course in patients with sarcoidosis.

Chronic Disease↗

PubMed2005

[The role of EQ5D self-classifier in assessing quality of life in patients with sarcoidosis].

INTRODUCTION: In medicine, quality of life is a very important issue. Nowdays, in our circumstances, it is an important part of diagnostic and therapeutic procedures. The aim of this study was to analyze the role of EQ5D questionnaire in patients with sarcoidosis. MATERIAL AND METHODS: EQ5D self-questionnaire was used in patients with sarcoidosis and we analyzed the obtained data. RESULTS: The analysis included patients with previously proved sarcoidosis--pulnmonary and extrapulmonary (bronchoscopy and other biopsies). All patients were treated at the Institute of Tuberculosis and Lung Diseases. We analyzed a group of 84 (19 male and 65 female) patients with average age of 45 years. Most patients had a chronic state of disease and were nonsmokers. In regard to the radiographic stage of pulmonary sarcoidosis, levels of disease activity (acute, chronic and relapse), levels of sACE, levels of sIgE, smokers--non smokers, and in regard to obtained scores, no statistically significant difference was found in examined groups, except in the group of patients with low level sIgE (score 0.276). CONCLUSION: EQ5D questionnaire is a good tool for analyzing the health status of patients with sarcoidosis, but still a more specific questionnaire should be designed for this multisystem disease.

Adolescent↗

PubMed2004

[Analysis of patients with tuberculosis and diabetes mellitus at the Institute of Pulmonary Diseases and Tuberculosis of the Clinical Center of Serbia (2000-2002)].

INTRODUCTION: Tuberculosis and diabetes mellitus are diseases that are commonly found together with adverse mutual effects. MATERIAL AND METHODS: The aim of this study was to analyze the incidence and association between tuberculosis and diabetes mellitus among TB patients hospitalized at the Institute of Pulmonary Diseases and Tuberculosis, Clinical Center of Serbia over the three-year period: 2000-2002. RESULTS: Among the tuberculous patients the average incidence of diabetes mellitus over the analyzed period was 9.8%. Most of the patients were above 55 years of age (52.8%), followed by 41.6% of middle aged (30-55 years) patients, while only a small number of patients (6.5%) belonged to the young population group (below 30). Males (64%) were more frequently affected than females (36%). Significant number of patients (61%) had a severe form of diabetes mellitus with frequent glycoregulation disorders necessitating either short-term or permanent insulin therapy. Analysis of clinical forms of tuberculosis at the time of detection revealed that 50% of patients had a moderately disseminated form of the disease with bilateral changes while the other 50% had a disseminated form. The average bacillarity was 56%. Radiological findings of tuberculosis in diabetics was manifested atypically in the lower pulmonary fields with bronchopneumonic shadows found in 11.1% of patients. CONCLUSION: Tuberculosis presents with changed clinical and radiological pictures in considerable number of diabetics, particularly elderly ones, resembling other unspecific lung diseases and thus it may cause differential-diagnostic dilemmas and delayed detection.

Adult↗