Biomedical subjects

Sohela S Hassan

Publications and source records attributed to Sohela S Hassan.

3 recordsLinked to original sources

PubMed2006

Ecologic effects on eye banking.

PURPOSE: To examine the climatic conditions at corneal donation for microbial categories of postkeratoplasty endophthalmitis that have been reported to a national surveillance registry. DESIGN: Retrospective case-control study. METHODS: Local weather information on the date of donor corneal procurement was tabulated for reported cases of endophthalmitis after penetrating keratoplasty and then compared between candidal endophthalmitis and postsurgical endophthalmitis that yielded bacteria or no microorganisms or that were not cultured. RESULTS: Compared with other postkeratoplasty endophthalmitis, candidal endophthalmitis after corneal transplantation occurred significantly (P < .001) more often when outdoor afternoon temperatures exceeded 75 F at the source eye bank than on cooler days. CONCLUSION: Higher exterior temperatures at donation may be associated with an increased relative risk of candidal transmission by keratoplasty, but a chain of causation that links the donor's environment to the recipient's infection remains to be elucidated.

Body Temperature↗

PubMed2006

The incidence and risk factors for developing dry eye after myopic LASIK.

PURPOSE: To determine the incidence of dry eye and its risk factors after myopic laser-assisted in situ keratomileusis (LASIK). DESIGN: Single-center, prospective randomized clinical trial of 35 adult patients, aged 24 to 54 years, with myopia undergoing LASIK. METHODS: setting and study population: Participants were randomized to undergo LASIK with a superior or a nasal hinge flap. They were evaluated at 1 week and 1, 3, and 6 months after surgery. intervention: Bilateral LASIK with either a superior-hinge Hansatome microkeratome (n = 17) or a nasal-hinge Amadeus microkeratome (n = 18). main outcome measures: The criterion for dry eye was a total corneal fluorescein staining score > or =3. Visual acuity, ocular surface parameters, and corneal sensitivity were also analyzed. Cox proportional-hazard regression was used to assess rate ratios (RRs) with 95% confidence intervals. RESULTS: The incidence of dry eye in the nasal- and superior-hinge group was eight (47.06%) of 17 and nine (52.94%) of 17 at 1 week, seven (38.89%) of 18 and seven (41.18%) of 17 at 1 month, four (25%) of 16 and three (17.65%) of 17 at 3 months, and two (12.50%) of 16 and six (35.29%) of 17 at 6 months, respectively. Dry eye was associated with level of preoperative myopia (RR 0.88/each diopter, P = .04), laser-calculated ablation depth (RR 1.01/microm, P = 0.01), and combined ablation depth and flap thickness (RR 1.01/microm, P = 0.01). CONCLUSIONS: Dry eye occurs commonly after LASIK surgery in patients with no history of dry eye. The risk of developing dry eye is correlated with the degree of preoperative myopia and the depth of laser treatment.

Adult↗

PubMed2005

Eye-banking risk factors for fungal endophthalmitis compared with bacterial endophthalmitis after corneal transplantation.

PURPOSE: To track the relative frequency and explore possible risk factors of fungal compared with bacterial endophthalmitis after corneal transplantation. DESIGN: Case-comparison study nested in a surveillance registry. METHODS: We examined, among recipients who underwent surgery from January 1991 through December 2003, demographic and eye-banking characteristics of postkeratoplasty endophthalmitis cases that were reported to the Eye Bank Association of America by US eye banks. Potential predictors of fungal compared with bacterial endophthalmitis were examined using multiple logistic regression. RESULTS: Of 234 reported cases of postkeratoplasty endophthalmitis reported by US eye bank, 46 cases (19.7%) were fungal, and 130 cases (55.6%) were bacterial. Concordant cultures of the residual donor corneoscleral rim or preservation medium occurred significantly more often with fungal than bacterial endophthalmitis (P = .009). After the introduction of Optisol-GS, the odds of bacterial relative to fungal endophthalmitis decreased by 77% (95% confidence interval, 44% - 91%). After adjustment for the preservation method and other eye-banking variables, the odds of fungal endophthalmitis was 3.4 (95% confidence interval, 1.6 - 7.4) times that of bacterial endophthalmitis, when donor corneal preservation was 4 days or longer. CONCLUSIONS: The frequency of postkeratoplasty bacterial endophthalmitis compared with fungal endophthalmitis fell after widespread use of a corneal preservation medium supplemented with gentamicin and streptomycin. Further improvements in corneal preservation procedures are needed.

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