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Biomedical subjects

Stanisław Błazewicz

Publications and source records attributed to Stanisław Błazewicz.

3 recordsLinked to original sources

[New composite implant for tracheal reconstruction--preliminary study].

Stenosis of trachea's diameter occurs the most often as complications after intubation and tracheotomy. Among the other reasons of narrowing of this organ the following are being named: mechanical injuries, chemical damages, primary and metastasis tumors. The therapy of trachea's stenosis includes both alternative and radical treatments. The radical treatment consists of surgical excision of the narrowed segment followed by reconstruction of trachea (anastomosing of free ends or filling of lost segment with use of auto- or allogenic material). There is no appropriate alloplastic material developed to date, the use of which in reconstructive surgery of large segment trachea defects would bring about positive long-term experimental results. The success of alloplastic material implantation in the reconstruction of large tracheal defects is limited by the fact that the biomechanical characteristics of replaced tissue are distinctly different from synthetic material. The work is devoted to evaluation of complex mechanical characteristic of natural sheep trachea before designing the proper synthetic material for large tracheal defects reconstruction. Various mechanical tests were conducted to study the mechanical behavior of total trachea. Samples of tissue cut out from trachea were also examined. The results revealed strong directional--dependent mechanical properties of trachea. Composite constituents, namely carbon fibers and biocompatible and biostable polysulfone were used to manufacture the implant.

Animals↗

[Study on polysiloxane resin-based composites for bone surgery application].

The study aimed at determination of mechanical and biological properties of three types of carbon fibers-based composites differing in matrix as potential materials for bone surgery. Three types of polymethylphenyl siloxane resins (produced by Lucebni zavody, Kolin, Czech Republic) differing with Si/C ratio were used as matrix. Carbon fibers T-300 (Torayca) were used as the reinforcement. The composite samples were manufactured by liquid impregnation of carbon roving followed by thermal curing. The resins were characterized by means of infrared spectroscopy. The strength and Young's modulus of the composite samples were determined in three-point bending test. The MTT tests were led in the presence of line KMA human macrophages and line hFOB 1.19 human osteoblasts. The results presented in this work indicate that mechanical properties of the composites are adequate from viewpoint of bone surgery requirement for load-bearing implants. The viability of macrophages cultures in contact with all examined samples was higher than 85%. The highest viability of human osteoblasts was obtained for composites based on L 901 and L 4102 resins-above 60%. The results suggest that the investigated polysiloxane-based composites are biocompatible, however their possible use as implants needs further study.

Cell Line↗

[In vitro study of polymer coatings on electronic elements].

The paper presents the results of investigations of polymer coatings used as capsules for implantable microelectronic devices for medical applications. Such devices work in artificial pacemakers and as feeding systems, in nerve ending stimulator sets. Biocompatible and biostable polysulfone capsules for integrated circuits and batteries have been prepared. Preliminary investigation of overall chemical stability of encapsulated electronic devices in Ringer's solutions, has been carried out as a function of immersion time. Influence of number of coating polysulfone layers on voltage-stability of batteries immersed in 0.9% NaCl solution has been measured with time. A comparative study of silicone (SIL) coating and double coating with silicone and polysulfone (SIL + PSU) in an in vitro test has been carried out.

Biocompatible Materials↗