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Biomedical subjects

Stavros Liatis

Publications and source records attributed to Stavros Liatis.

9 recordsLinked to original sources

Critical review of the international guidelines: what is agreed upon--what is not?

The nutrition recommendations of 6 major scientific organizations (the American Diabetes Association, the Diabetes and Nutrition Study Group of the European Association for the Study of Diabetes, the Canadian Diabetes Association, the Joslin Diabetes Center and Joslin Clinic, the American Association of Clinical Endocrinologists and Diabetes UK) are reviewed. They all agree that weight loss (with reduction in energy intake and increase in physical activity) is an important therapeutic strategy in all overweight/obese individuals who have or are at risk of type-2 diabetes. Very low carbohydrate diets are not considered appropriate. The recommended proportion varies slightly (from 40 to 65%). The concept of the glycemic index is stressed as important in nearly all guidelines. Fiber intake is advised, up to 50 g/day, if tolerated. Protein intake (for normal kidney function) is advised to range from 10 to 20% of total energy. A low fat diet (<30-35%) is recommended by all. Saturated fat and trans-fatty acids should be restricted to <10% and dietary cholesterol to <300 mg/day. Monounsaturated fatty acids are generally considered beneficial and should replace saturated fat or carbohydrates in low-fat diets. Polyunsaturated fatty acids (PUFAs) should comprise about 10%, with the n-3 PUFAs being more beneficial, especially for high triglyceride levels. Alcohol intake has cardioprotective effects when used in moderation. Routine supplementation of the diet with antioxidants and vitamins is not necessary.

Diabetes Mellitus↗

Pseudomonas luteola cutaneous abscess and bacteraemia in a previously healthy man.

Pseudomonas luteola is uncommonly implicated in clinical infections, but it constitutes a significant nosocomial pathogen causing mainly infections associated with foreign material. This report describes an unusual case of a Pseudomonas luteola strain that infected and caused cutaneous abscess and bacteraemia in a previously healthy man.

Abscess↗

Cardiac autonomic nervous system activity in obesity.

The development of obesity is caused by a disturbance of energy balance, with energy intake exceeding energy expenditure. As the autonomic nervous system (ANS) has a role in the regulation of both these variables, it has become a major focus of investigation in the fields of obesity pathogenesis. The enhanced cardiac sympathetic drive shown in most of the studies in obese persons might be due to an increase in their levels of circulating insulin. The role of leptin needs further investigation with studies in humans. There is a blunted response of the cardiac sympathetic nervous system (SNS) activity in obese subjects after consumption of a carbohydrate-rich meal as well as after insulin administration. This might be due to insulin resistance. It is speculated that increased SNS activity in obesity may contribute to the development of hypertension in genetically susceptible individuals. It is also speculated that the increase in cardiac SNS activity under fasting conditions in obesity may be associated with high cardiovascular morbidity and mortality.

Autonomic Nervous System↗

Fusobacterium necrophorum septicemia following Epstein-Barr virus infectious mononucleosis.

We report herein a case of a 20-year-old previously healthy man who presented, 25 days after the onset of clinically and serologically confirmed Epstein-Barr virus (EBV) infectious mononucleosis, Fusobacterium necrophorum septicemia. The diagnosis of postanginal septicemia was confirmed by repeated demonstration of fusiform, obligate anaerobic, Gram-negative bacilli in anaerobic blood cultures, identified as F. necrophorum 15 days after admission. This case report aims at underlining the need of taking into consideration the possibility of severe Fusobacterium septicemia in previously healthy patients following EBV infectious mononucleosis in order to prevent increased mortality and morbidity.

Journal Article↗

Stenotrophomonas maltophilia: a serious and rare complication in patients suffering from burns.

Stenotrophomonas maltophilia is rarely implicated in clinical infections but it constitutes a significant nosocomial pathogen, especially in immunocompromised patients. This report describes the first case of a generalised infection caused by S. maltophilia that included bacteremia, wound and respiratory tract infection in a patient suffering from burns. Given the emergence of S. maltophilia nosocomial infections, especially in patients with burns, isolation of the bacterium from blood cultures should prompt the commencement of adequate antibiotic treatment.

Burns↗

Primary carnitine deficiency in a male adult.

The case is described of a 36 year-old man who presented with progressive proximal muscle weakness and weight loss. His serum creatine phosphokinase (CPK) levels were markedly elevated. The muscle biopsy showed lipid storage myopathy. The muscle carnitine concentration was extremely low (5.6% of normal levels), establishing the diagnosis of myopathic carnitine deficiency. The disorder was considered as primary because there were no indications of any other identifiable condition which could result in a secondary carnitine deficiency. The patient was treated with oral L-carnitine (2 g per day) and showed rapid improvement. Primary myopathic carnitine deficiency is a curable disorder and therefore it should always be considered as a potential diagnosis in cases of myopathy in young adults.

Adult↗