PubMed Health⌕ Search

Biomedical subjects

Stefan Lohmander

Publications and source records attributed to Stefan Lohmander.

13 recordsLinked to original sources
PubMed2005

Concomitant therapy: an outcome variable for musculoskeletal disorders? Part 2: total joint replacement in osteoarthritis trials.

Interest has grown in using the requirement of total joint replacement (TJR) as a "hard" outcome measure. Limitations exist, however, in the use of such an outcome, in particular the variability in the decision to perform surgery, length of surgical waiting lists, and sensitivity to change. This special interest group is exploring ways of retaining the clinical relevance of TJR but overcoming the problems--2 alternative outcomes are being considered: "time to physician's decision to recommend surgery" and "time to fulfilling criteria for total joint replacement."

Arthroplasty, Replacement↗
PubMed2003

Osteoarthritis.

Explore the source record for details and available documents.

Analgesics↗
PubMed2002

[Icelandic genealogical registry sheds light on the significance of heredity in osteoarthritis].

Osteoarthritis is a heterogeneous and multifactorial disease with many pathogenic mechanisms implicated in its development and progression. Although osteoarthritis is a manifestation of certain metabolic, mechanical or inflammatory events, several distinct forms of osteoarthritis are inherited as dominantly acquired Mendelian traits. Gathering evidence is showing that inheritance and possible mutations in genes associated with osteoarthritis can play a major role in the common form of osteoarthritis in many joints. By the introduction of new biological methods for finding gene defects the search for possible gene defects have taken mainly three forms: (1) Parametric linkage analysis of rare families in which osteoarthritis segregates as a Mendelian trait; (2) model free linkage analysis of affected sibling pairs, and (3) association analysis of known candidate genes. Mutations today known to be associated with osteoarthritis all occur in relatively rare syndromes or diseases, which have osteoarthritis as a major component. In recent years many loci have been found associated with the "common osteoarthritis phenotype". Chromosomes 2, 4, 6, 11 and 16 were identified in multiple genome scans and are therefore the most likely to encode susceptibility. Ongoing studies will lead to classifications of the "common osteoarthritis" based on the exact causative gene defects, rather than on their variable clinical and radiographic phenotype. Hopefully, these studies will lead to future new therapy of osteoarthritis.

Databases, Factual↗
PubMed2002

[Many paths converge in arthritis. Awareness of risk factors and illness mechanisms increase steadily].

Osteoarthritis does not deserve the term "degenerative joint disease", the course of the disease is characterized by dynamic changes in both synthesis and degradation of cartilage and other joint tissues. At the end stage all tissues of the joint are involved, not only the cartilage. In the early phases of the disease, changes in cartilage metabolism can be detected through assay of biomarkers in joint fluid, blood or urine. These changes evolve into macroscopic changes of fibrillation and loss of cartilage. Concomitantly, changes occur in other joint tissues and bone. The more advanced stages of change, as loss of joint space and osteophytes, may be detected by radiological examination. Osteoarthritis is a complex disease where genetic variations in several loci appear to interact with environmental factors to initiate and drive disease progression towards several different phenotypes. These may be recognized in different joint patterns, predominant inflammation or lack of inflammation, predominant loss of joint space or osteophytosis, etc. Increased occupational joint load, joint injuries and obesity are well recognized risk factors for osteoarthritis.

Adult↗
PubMed2002

Osteoarthritis.

Explore the source record for details and available documents.

Analgesics↗
PubMed2002

Osteoarthritis.

Explore the source record for details and available documents.

Analgesics↗