Stereoselective syntheses of enantiomerically pure 2,5-disubstituted dihydropyrans based on olefin metathesis.
A short synthesis of 2,5-disubstituted dihydropyrans starting from d-mannitol as a chiral building block is described. Our synthetic approach combines ruthenium-catalyzed ring closing olefin metathesis and palladium-catalyzed nucleophilic substitution.
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