Biomedical subjects

Stefan Spitzer

Publications and source records attributed to Stefan Spitzer.

3 recordsLinked to original sources

PubMed2006

Transient ST-segment-elevation during pulmonary vein ablation using circumferential coiled microelectrodes in a prospective multi-centre study.

AIMS: Paroxysmal atrial fibrillation (PAF) is predominantly triggered by focal ectopies located within the pulmonary veins (PV). The BITMAP Study (Breakthrough and Isolation Trial: Mapping and Ablation of Pulmonary Veins) investigated prospectively the safety and efficacy of a catheter design with circumferential mapping and ablation electrodes. We report the phenomenon of ST-segment-elevation during catheter placement in the left atrium (LA) and superior PVs in this multi-centre study. METHODS AND RESULTS: Forty-three patients (57+/-10 years) with PAF were included in this study. Radiofrequency catheter (RFC) ablation supported by the 4F REVELATION Helix microcatheter (Cardima Inc., Freemont, CA, USA) with eight distal-coiled microelectrodes for bipolar mapping and ablation. RFC was applied at the ostial region of PV (30 W, 45-50 degrees C) with a maximum of four RFC applications per electrode. In four of the 43 patients from three centres, we recorded the occurrence of ST-segment-elevation greater than 0.2 mV and accompanying left thoracic discomfort. The ECG changes and the symptoms started abruptly and lasted for 4.2+/-2.2 min. Pericardial effusion could instantaneously be excluded by echocardiography in all cases. Coronary angiograms were performed in three patients with the longest episodes; no thrombotic material or air emboli were present. The symptoms and the ECG changes resolved completely in all patients. CONCLUSION: The phenomenon of ST-segment-elevation during LA- and PV-mapping in patients with PAF may be a common occurrence. In this prospective multi-centre trial, we demonstrated the reversibility of this phenomenon; no cardiovascular or cerebral damage was reported during both the procedure and the follow-up. Although the mechanism is still unclear, vasospasm may contribute to this phenomenon because of autonomic dysregulation.

Adult↗

PubMed2005

Mortality after cardiac surgery with or without microwave ablation in patients with permanent atrial fibrillation.

BACKGROUND AND AIM OF THE STUDY: The surgical treatment of atrial fibrillation (AF) by Cox and other ablation methods shows a 50-90% conversion rate to sinus rhythm. However, to date no study has addressed the influence of ablation on the mortality rate. METHODS: The perioperative and postoperative mortalities of 210 consecutive patients with permanent AF was investigated for up to two years after cardiac surgery with (n = 111) or without (n = 99) endocardial microwave ablation within the framework of a prospective register study. All patients were followed up. RESULTS: In the ablation group, one patient (0.9%) died perioperatively, seven died during the first year of follow up (6.3%), and nine in the second year of follow up (8.1%). In the control group, five patients died perioperatively (5.1%), 12 died in the first year of follow up (12.1%), and 22 in the second year of follow up (22.2%). During the two-year follow up period, significantly more patients died in the control group than in the ablation group (Log-Rank test: p = 0.0051). CONCLUSION: The results of this register study showed that among patients with permanent AF who underwent cardiac surgery with ablation, mortality was significantly lower than in those who underwent comparable surgery but without ablation. The marked difference in mortality was essentially based on the typical clinical consequences of AF (e.g. thromboembolic complications, cardiac arrhythmias and bleeding complications due to anticoagulation therapy), which occurred less often in the ablation group.

Adult↗

PubMed2002

Combined atrial fibrillation and mitral valve surgery using microwave technology.

Atrial fibrillation is associated with a significant morbidity and mortality and is typically related to patients with mitral valve disease. Microwave ablation is a new option for surgical treatment of chronic atrial fibrillation. We present our experience with surgical treatment of mitral valve disease and microwave ablation in patients with chronic atrial fibrillation. In 105 patients (73 women, 32 men, 68.6 +/- 8 years of age from 45 to 83 years, ejection fraction 28% to 80%, left atrial diameter 56 +/- 9.1 mm from 35 to 97 mm) with mitral valve disease, chronic atrial fibrillation was documented for 8.6 +/- 6.8 years. Microwave ablation was performed using a continuous ablation line starting at the posterior mitral valve annulus and incorporating the interior of all pulmonary veins. In 33 patients, mitral valve reconstruction was performed. Ten patients received biologic valve replacement; 3 of them got a stentless quattro mitral valve prosthesis. Survival rate was 99.1% (n = 104). In the 6-month follow-up, 42 of 69 patients were in sinus rhythm (61%); in the 1-year follow-up, 37 of 64 patients were in sinus rhythm (57.8%). Microwave ablation is a safe and efficient method for surgical treatment of chronic atrial fibrillation in patients with mitral valve disease.

Aged↗