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Steinar Sørnes

Publications and source records attributed to Steinar Sørnes.

2 recordsLinked to original sources
PubMed2006

Linezolid and human polymorphonuclear leukocyte function.

BACKGROUND: To examine whether linezolid, a new oxazolidinone antibiotic, has an effect on human polymorphonuclear leukocyte (PMN) function. METHODS: Flow-cytometric techniques for the demonstration of PMN chemotaxis towards zymosan-activated serum, and phagocytosis and respiratory burst after incubation in linezolid. RESULTS: Linezolid at concentrations of 10- 160 mg/l did not significantly influence PMN function as measured by chemotaxis, phagocytosis and respiratory burst. CONCLUSIONS: Linezolid at therapeutic or supratherapeutic concentrations does not influence human PMN function. This applies to the chemically pure substance as well as to the commercial preparation containing additives for intravenous infusion.

Acetamides↗
PubMed2004

Comparative analysis of amplified fragment length polymorphism and pulsed field gel electrophoresis in a hospital outbreak and subsequent endemicity of ampicillin-resistant Enterococcus faecium.

Reliable molecular methods for determination of relatedness between bacterial isolates have become increasingly important to evaluate outbreaks and endemic situations with nosocomial pathogens. In the present study Simpson's index of diversity with calculated confidence intervals was used to compare amplified fragment length polymorphism (AFLP) and pulsed field gel electrophoresis (PFGE) analysis of a hospital outbreak of ampicillin-resistant Enterococcus faecium and subsequent endemicity. The outbreak, in a Norwegian tertiary hospital, of infections caused by these enterococci started in 1995 and increased in 1996 after which the situation turned endemic. The purpose of this study was to compare the two methods in this setting and to determine the length of time during an outbreak that these methods are sufficiently valid to be of value for hospital infection control efforts. One hundred and sixty clinical isolates from urine specimens collected during the period 1995-1999 were included. The findings indicate that PFGE and AFLP are equally discriminative and could in this setting be used for typing purposes over the whole 5-year period.

Ampicillin↗