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Biomedical subjects

Stephen J Harris

Publications and source records attributed to Stephen J Harris.

3 recordsLinked to original sources

Holiday waistline. Jolly, fit and fat: should we be singing the "Santa Too Fat Blues"?

Santa Claus's apparent weight gain, much chronicled in the popular media, raises the question of whether his jolly persona could be at risk. We investigate why Santa remains jolly, even though he is becoming obese, and what factors could be keeping him upbeat. Measures of body mass, mental health and physical activity were collected from a representative cohort of Canadian adults surveyed in 1988 and again 15 years later. Remaining sedentary was generally associated with a low jolly quotient (JQ). In addition, a "healthy weight" pattern and remaining "sedentary" was associated with higher odds of a low JQ than remaining or becoming obese (from overweight) while staying active. Although mechanisms for understanding how Santa remains active are yet to be elucidated, we have uncovered a few clues and conclude that Santa indeed remains jolly particularly because he is active, and that a GIFT (graduated intensity fitness training) is good for combating the "Santa Too Fat Blues."

Activities of Daily Living↗

A conserved RNA structure within the HCV IRES eIF3-binding site.

The hepatitis C virus (HCV) internal ribosome entry site (IRES) is recognized specifically by the small ribosomal subunit and eukaryotic initiation factor 3 (eIF3) before viral translation initiation. Using extensive mutagenesis and structure probing analysis, we show that the eIF3-binding domain of the HCV IRES contains an internal loop structure (loop IIIb) and an adjacent mismatched helix that are important for IRES-dependent initiation of translation. NMR studies reveal a unique three-dimensional structure for this internal loop that is conserved between viral isolates of varying primary sequence in this region. These data indicate that internal loop IIIb may be an attractive target for structure-based design of new antiviral agents.

5' Untranslated Regions↗