Biomedical subjects
Steven L Shumak
Publications and source records attributed to Steven L Shumak.
How to read clinical journals: XII. How you too can profit from pharmaceutical advertisements.
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C-reactive protein for the prediction of cardiovascular risk: ready for prime-time?
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Is there sustained renal benefit from previous intensive insulin therapy in people with type 1 diabetes?
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How to read clinical journals: XI. Everything you always wanted to know about editorials (but were afraid to ask).
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A cryptic cause of cryptococcal meningitis.
Cryptococcus neoformans commonly causes opportunistic infection in immunocompromised patients, especially in patients with AIDS. The CD4+ T-lymphocyte count is measured in patients with HIV infection, because it signals an increased risk of opportunistic infection and a decline in immunological function. We report a case of cryptococcal meningitis in a patient with persistently low CD4+ cell counts without evidence of HIV infection. The patient's underlying immunocompromised state was attributed to idiopathic CD4+ T-lymphocytopenia (ICL), a recently described syndrome characterized by depletions in the CD4+ T-cell subsets without evidence of HIV infection. Immunodeficiency can exist in the absence of laboratory evidence of HIV infection, highlighting the importance of evaluating T-cell subsets in patients who present with unusual infections.