Brain metastases.
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Antineoplastic Agents↗
Biomedical subjects
Stuart H Burri
Publications and source records attributed to Stuart H Burri.
Brain metastases treated with radiosurgery alone: an alternative to whole brain radiotherapy?
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Brain Neoplasms↗
Black and white patients fare equally well when treated with postlumpectomy radiotherapy.
PURPOSE: Some previous studies have demonstrated that black patients have inferior local-regional control and disease-free survival when treated with postlumpectomy radiotherapy. The intention of this study was to analyze the same outcomes with a larger series of black patients. METHODS: A retrospective chart review was performed at an academic referral center, a community hospital, and an inner-city public hospital. RESULTS: A total of 270 patients that received postlumpectomy radiotherapy were reviewed. Of those, 102 were black, 162 white, and six nonblack, nonwhite. The black patients were statistically significantly more likely to present with higher-stage disease (Stage II: 43.1% vs. 32.1%), positive lymph nodes (29.4% vs. 14.8%), higher-grade disease (Grade III: 35.3% vs. 24.1%), and age < 45. The actuarial local control at five years in the black patients was 95.5% and in the white patients was 94.8%. The actuarial five-year disease-free survival in the black patients was 90.3% and in the white patients was 91.7%. There was no statistically significant difference in either local control or disease free-survival in the black and white patients when matched by stage. CONCLUSION: At five years, the local control and disease-free survival for black patients are equally as good as white patients.
Adult↗
In regard to Regine et al. Risk of symptomatic brain tumor recurrence and neurologic deficit after radiosurgery alone in patients with newly diagnosed brain metastases: results and implications.
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Brain Neoplasms↗
Breast conservation is an effective option in Black, medically indigent patients.
The purpose of the study was to evaluate the efficacy of lumpectomy and postoperative radiotherapy in an African-American, medically indigent population. From 1980 through 1996, a retrospective chart review was undertaken of the patients treated with radiotherapy after lumpectomy at an inner city hospital, whose patients are primarily African American and uninsured. One hundred and one patients were treated with breast conservation during this time. Of those, 72 were African American and with invasive carcinoma. The data were analyzed using JMP IN (SAS Institute). The study found that African-American patients with invasive carcinoma had 95.2% local control at 5 years and 87.9% at 10 years. The disease-free survival was 84.6% at 5 years and 65.3% at 10 years. Patients that received less than 50 Gray to the tumor bed had inferior local control, disease-free survival, and overall survival (p < 0.0001 for all three). The 5-year and 10-year local control for DCIS, in a limited number of patients, was 95.2%. We conclude that lumpectomy followed by radiotherapy is an effective treatment strategy in the high-risk population of African-American, medically indigent patients. The local control and disease-free survival compare favorably to published controls in this traditionally high-risk patient population.
Black People↗