Biomedical subjects

Subhashini Yaturu

Publications and source records attributed to Subhashini Yaturu.

3 recordsLinked to original sources

PubMed2002

Levels of soluble human leukocyte antigen class 1 are increased in Graves' disease and toxic multinodular goiter and correlate with the levels of triiodothyronine.

Soluble human leukocyte antigens class 1 (sHLA-1) are postulated to play a role in immunomodulation. Thyroid hormones and thyroid stimulating hormone influence expression of major histocompatibility complex (MHC) class 1 genes. We hypothesized similar changes in sHLA-1 with changes in the thyroid hormone. We measured serum levels of sHLA-1 in 140 normal controls, 11 patients with toxic multinodular goiter and 26 patients with active Graves' disease. On follow-up 1 year after treatment for Graves' disease, we repeated the measurement of the levels of sHLA-1 in 21 patients. Levels of sHLA-1 were markedly elevated in the group of patients with active Graves' disease compared to the normal controls (p = 0.00016). The levels of sHLA-1 were also elevated significantly in patients with toxic multinodular goiter compared to normal controls (p = 0.034). There is no significant difference between genders and the two races tested among patients with Graves' disease in contrast to controls. Free triiodothyronine (T(3)) levels positively correlated with the levels of sHLA-1 (r = 0.61). On follow-up after treatment for Graves' disease, levels of sHLA-1 decreased by 62% with p = 0.0006 (active Graves vs. follow-up). We conclude that there is a definite association between thyroid hormones and sHLA-1 levels.

Adult↗

PubMedDate not supplied

Differentiated thyroid carcinoma with functional autonomy.

OBJECTIVE: To present a case of papillary carcinoma in an autonomously hyperfunctioning thyroid nodule. METHODS: We chronicle the clinical and laboratory findings in a patient with a painless neck mass, with a particular focus on the pathologic findings after surgical removal of the right thyroid lobe. RESULTS: A 39-year-old woman had an enlarging nodule of the right thyroid lobe. Results of thyroid function tests suggested subclinical hyperthyroidism. Two months later, the patient complained of increasing swelling in the neck (but still had no symptoms suggestive of hyperthyroidism). Thus, resection of the right thyroid lobe was performed. Pathologic analysis disclosed low-grade papillary thyroid carcinoma within the nodule, with a small rim of compressed inactive-appearing thyroid tissue surrounding the nodule. Subsequently, she underwent total thyroidectomy and follow-up care for thyroid carcinoma. CONCLUSION: Although solitary hyperfunctioning nodules of the thyroid gland are usually considered benign, the current case suggests that the diagnosis of autonomous thyroid nodules does not preclude thyroid carcinoma in a functioning nodule.

Adult↗

PubMedDate not supplied

Gynecomastia attributable to human chorionic gonadotropin-secreting giant cell carcinoma of lung.

OBJECTIVE: To describe a patient with human chorionic gonadotropin (hCG)-secreting giant cell carcinoma of the lung manifesting as painful gynecomastia, which resolved after surgical treatment. METHODS: We present the clinical, radiologic, and clinical course of our patient, who presented with painful gynecomastia. RESULTS: A 51-year-old man presented with a lung mass and rapidly progressing bilateral painful gynecomastia. Hormonal evaluation revealed high levels of hCG beta subunit, estradiol, and total and free testosterone and suppressed levels of luteinizing hormone and follicle-stimulating hormone. The patient underwent resection of the right upper and middle lobes of the lung. After the surgical procedure, the levels of hCG and estradiol rapidly decreased, and the gynecomastia resolved completely within 3 months. Fluctuation in the levels of serum hCG paralleled the clinical course of the lung tumor. CONCLUSION: Although gynecomastia is a common disorder, hormonal work-up including hCG beta subunit should be done in an adult male patient presenting with rapidly progressing or recent onset of painful gynecomastia. Lung cancer should be considered in the differential diagnosis of gynecomastia attributable to ectopic production of hCG beta subunit.

Carcinoma, Giant Cell↗