ROSE system for treatment of cholera dehydration.
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Biomedical subjects
Publications and source records attributed to Suharjono.
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The upper intestinal microflora was studied in 10 malnourished Indonesian children using the paediatric Enterotest Capsules. Trophozoites of Giardia lamblia were found in 2 specimens, profuse fungal mycelia in 3, and ascaris worms and eggs in 1. In 9 patients an abnormally profuse small intestinal bacterial flora was found. Provided precautions are taken to exclude artefactual contamination of the line on its withdrawal, this is a safe and simple method for studying the upper gut flora which could be applied to field conditions since it does not require radiological facilities.
Basal gastric acid output was reduced in 9 out of 14 infants and young children with malnutrition compared with 21 age-matched controls. In all the patients the response of the gastric mucosa to stimulation by pentagastrin was impaired, and gastritis of variable severity was present in 8 out of the 9 patients in who biopsies were performed. Impaired gastric acid secretion probably contributes towards bacterial overgrowth and diarrhoeal diseases in malnourished children.
Intestinal immunoglobulin levels were quantitated in undernourished Indonesian children with enteric infections and normally nourished Indonesians with and without enteric infections. These were compared to the same parameters in Australian Aboriginal children (also suffering undernutrition) and normal Caucasian children. Children with enteric infections displayed equally elevated levels of intestinal immunoglobulin irrespective of their nutritional status. Intestinal infections appeared to elevate IgG levels more than secretory IgA levels in the age group examined. However, it appeared likely that some of the EgG was serum-derived whereas the IgA appeared to be locally produced. There was no apparent deficiency in the capacity of undernourished children to manufacture and secrete immunoglobulin in the gut.
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