Biomedical subjects

Suk-Kyu Chang

Publications and source records attributed to Suk-Kyu Chang.

4 recordsLinked to original sources

PubMed2006

Fluorogenic Hg2+-selective chemodosimeter derived from 8-hydroxyquinoline.

[reaction: see text] A new thioamide derivative of 8-hydroxyquinoline-benzothiazole was prepared, and its fluorogenic chemodosimetric behaviors toward transition-metal ions were investigated. The thioamide derivative showed highly Hg2+-selective fluorescence enhancing properties (167-fold) in 30% aqueous acetonitrile solution. The selective and sensitive signaling behaviors were found to originate from the Hg2+ ion induced transformation of the very weak fluorescent thioamide derivative into a highly fluorescent amide analogue.

Journal Article↗

PubMed2006

Hg2+-selective OFF-ON and Cu2+-selective ON-OFF type fluoroionophore based upon cyclam.

[structure: see text]. A new cyclam derivative having two different fluorophores of pyrene and NBD subunits was prepared, and its Hg2+- and Cu2+-selective signaling behaviors were investigated. The detection limits for the analysis of Hg2+ and Cu2+ ions were found to be 7.9 x 10(-6) and 2.6 x 10(-7) M in aqueous acetonitrile solution (H2O-CH3CN = 10:90, v/v), respectively. The compound also exhibited a selective Hg2+/Cu2+-induced OFF-ON-OFF type of signaling pattern that can be utilized for the construction of functional supramolecular switching systems.

Journal Article↗

PubMed2005

Diametrically disubstituted cyclam derivative having Hg2+-selective fluoroionophoric behaviors.

[reaction: see text] A new fluoroionophore has been synthesized by appending two signaling pyrenylacetamide subunits on the binding motif of 1,8-dimethylcyclam. The designed compound exhibited highly selective and sensitive fluoroionophoric behavior toward Hg(2+) ions of excimer emission in aqueous dioxane (dioxane/H(2)O = 1:9, v/v) solution with a detection limit of 1.3 x 10(-)(6) M. The "ON-OFF" type signaling behavior of the fluoroionophore is due to the metal ion induced conformational changes from folded to open-winged conformations by exploiting the two nearby appended pyrenyl fluorophores.

Fluorescent Dyes↗

PubMed2004

New Hg2+-selective chromo- and fluoroionophore based upon 8-hydroxyquinoline.

A new 8-hydroxyquinoline derivative having an appended boron-dipyrromethene function has been prepared, and its metal ion sensing properties were investigated. The designed compound exhibited pronounced Hg(2+)-selective on-off-type fluoroionophoric properties among the representative transition- and heavy-metal ions in aqueous dioxane solution. The fluorescence was efficiently quenched more than 98% with 5 equiv of Hg(2+) ions, and the detection limit was found to be 5 x 10(-)(6) M in a dioxane-water (1:3, v/v) solvent system. The ionophore also showed a selective chromogenic behavior toward Hg(2+) ions by changing the color of the solution from light amber to red, which can be detected with the naked eye.

Journal Article↗