Biomedical subjects

Suling Hong

Publications and source records attributed to Suling Hong.

3 recordsLinked to original sources

PubMed2005

[The expression of cytokines in experimental otitis media with effusion].

OBJECTIVE: To explore the relationship between type I allergic reaction and OME and the expression of Th1, Th2 cytokines in the middle ear mucosa in OME. METHOD: BALB/C mice were randomly divided into experimental group (Exp), control group I (Con1) and control group II (Con2), BALB/C mice were sensitized to ovalbumin (OVA) and challenged transtympanically. The thickness of mucosa, the infiltration of eosinophils were detected by hematotoxylin-eosin staining (HE staining), the expression of IL-4, IL-5, IFN-gamma and IL-12 were examined by immunohistochemistry. RESULT: In experimental group, the expression of IL-4, IL-5, the thicknesss of mucosa and the numbers of eosinophils were significantly higher than those of Con1, Con2. But the expression of IFN-gamma, IL-12 were both significantly low. The concentration of IL-5 were positively correlated with the number of eosinophils in mucosa. CONCLUSION: This study demonstrates that type I allergic reaction, Th2 cytokines have an important effect on OME.

Animals↗

PubMed2005

[Correlations between BCG-PSN and tuberculin responses].

OBJECTIVE: To investigate the correlations between tuberculin responses and allergic rhinitis treated by BCG-PSN. METHOD: A total 60 patients with allergic rhinitis were randomly divided into BCG-PSN treated group and control group. All patients were given purified protein derivate (PPD), and PPD induration were recorded after 72 h, also the eosinophil cationic protein (ECP) and total IgE (TIgE) in serum were assayed with Pharmacia UniCAP System. RESULT: ECP and tIgE levels of patients treated by BCG-PSN were significantly lower than before treatment (P < 0.01). 37.5% patients who had negative reaction had induration after treatment using BCG-PSN. CONCLUSION: These results indicate that exposure BCG-PSN can correct the imbalance state of Th1 and Th2 cytokines and inhibit allergic airway inflammation and control allergic rhinitis.

Adolescent↗

PubMed2003

[Expression and significance of proliferation marker and apoptosis-related genes in benign and malignant epithelial lesions of the larynx].

OBJECTIVE: In order to study the ki-67, bcl-2, bax proteins expression and significance in the benign and malignant epithelium of the larynx. METHOD: An immunohistochemical S-P assay was used to detect the expression of ki-67, bcl-2, bax in LSCCs, epithelial dysplasia, papillomas, simple hyperplasia and normal laryngeal epithelium. RESULT: The mean value of ki-67 was 52.0%, 50.0%, 47.8%, 41.6%, 10.0% respectively. The different was statistically significant between LSCCS or dysplasia and normal laryngeal epithelial (P < 0.05). The mean value of bcl-2 was 44.0% in LSCCs, 11.0% in dysplasia, 0% in other three epithelial lesions of the larynx. Bcl-2 was highly positive in LSCCs compared to the other lesions (P < 0.05, P < 0.01, P < 0.01). The expression of bax was 76.0%, 77.8%, 69.6%, 58.3%, 80.0%. In papillomas, there was statistically significant positive correlation between Bcl-2 and ki-67. CONCLUSION: Ki-67 and Bcl-2 coexpression may play a role in the uncontrolled proliferation in papillomas. Ki-67, bax, Bcl-2 could help in estimation the premalignant stages of the larynx.

Apoptosis↗