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Biomedical subjects

Summer R Youker

Publications and source records attributed to Summer R Youker.

4 recordsLinked to original sources
PubMed2005

Combined Merkel cell carcinoma and atypical fibroxanthoma.

BACKGROUND: Although there are reports of squamous cell carcinoma arising within and adjacent to Merkel cell carcinoma, and one report of an atypical fibroxanthoma-like tumor arising in an irradiated recurrent Merkel cell carcinoma, there have previously been no reports of an immunohistochemically verified atypical fibroxanthoma occurring in conjunction with a Merkel cell carcinoma. OBJECTIVE: We report on a neoplasm with distinct features of both Merkel cell carcinoma and atypical fibroxanthoma. METHODS: Histologic and immunohistochemical evaluations were performed. RESULTS: Our results verify the finding of a combined Merkel cell carcinoma and atypical fibroxanthoma. CONCLUSION: This case is an interesting and unusual combination of tumors. The origin of the Merkel cell carcinoma is revisited. Debated origins include neuroendocrine, epithelial, and pleuripotent stem cell.

Aged↗
PubMed2003

White piedra: further evidence of a synergistic infection.

White piedra is a fungal infection of the hair shaft caused by Trichosporon beigelii. A synergistic coryneform bacterial infection is often present with T beigelii. White piedra, although not commonly reported to infect scalp hair in North America, is an important consideration in the differential diagnosis of scalp hair concretions. We report a case of white piedra of scalp hair with synergistic coryneform bacterial infection in two sisters, both US natives. Culture and light and electronmicroscopic evidence of the synergistic infection are presented.

Actinomycetales Infections↗
PubMed2003

Merkel cell carcinoma.

Merkel cell carcinoma is an aggressive tumor that should be treated early and aggressively. Although there are 5 published cases of spontaneous regression of Merkel cell carcinoma, a patient's best chance for survival is early detection with either wide local excision or Mohs' micrographically controlled margins with a final 5- to 10-mm layer. This should be followed by sentinel lymph node biopsy with lymph node dissection of the draining basin if metastases are discovered. Adjuvant radiation to the primary site and the draining basin should follow. Although this aggressive approach to treatment is not appropriate for every case, the literature, although scanty, supports this. Chemotherapy with or without additional radiation therapy should be offered to patients with advanced disease, mostly for palliation. The need for prospective trials and longer follow-up for larger series of patients is obvious.

Carcinoma, Merkel Cell↗