Biomedical subjects

Surachai Likasitwattanakul

Publications and source records attributed to Surachai Likasitwattanakul.

3 recordsLinked to original sources

PubMed2005

Serotonin syndrome: a case report.

Serotonin syndrome is a rare but potentially fatal complication of drugs that have effects on central nervous system serotonin. It is characterized by sudden onset of altered mental status, increased neuromuscular activity and autonomic instability. The author reports a child with suprasellar region tumor who presented with depression and obsessive-compulsive disorder and received a combination of sertaline (selective serotonin reuptake inhibitor) and clomipramine (tricyclic antidepressant). Symptoms of serotonin syndrome occurred within 24 hours after increasing the dose of sertaline. The patient's symptoms resolved rapidly with discontinuation of the offending drugs and supportive care.

Child↗

PubMed2005

Epilepsy with continuous spikes and wave during slow sleep: A case report.

This report presents a 5.5-year-old girl who presented with multiple types of seizure disorder along with behavioral change, cognitive deterioration, and language impairment. Electroencephalography showed nearly continuous spike-wave during slow wave sleep. Both clinical and electrographic findings were consistent with epilepsy with continuous spikes and wave during slow sleep (CSWS). Although the seizures were well controlled with conventional antiepileptic drugs, improvement of behavioral, cognitive, and language functions was observed only after adding corticosteroid as an adjunctive treatment. Corticosteriod may have a role in treatment in children with CSWS.

Child, Preschool↗

PubMed2004

Cryptococcosis in HIV-infected children.

Between January 1994 and December 2001, 21 HIV-infected children were diagnosed as having cryptococcosis. The 8-year point prevalence of cryptococcosis among hospitalized HIV-infected patients was 2.97%. Medical records of 19 patients were available for review. Sixteen patients had cryptococcal meningitis. Of these patients, cryptococcal antigen in the cerebrospinal fluid and sera were positive in all tested samples. India ink preparations were positive in 94% of cases. However, the routine CSF examination was normal in 50% of cases. All patients but one received antifungal treatment. Six patients died during treatment, the others (13 patients) were successfully treated. Relapse occurred in 2 patients despite secondary prophylaxis. Two patients died later from other causes and nine were lost to follow-up. We conclude that cryptococcal meningitis was the most common clinical presentation of cryptococcosis among HIV-infected children. HIV-infected children who present with fever, with or without central nervous system signs, should have a lumbar puncture and CSF sent for cryptococcal antigen and culture.

AIDS-Related Opportunistic Infections↗