Interferon-alpha response and signal transduction pathway in transitional carcinoma cell lines.
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Antineoplastic Agents↗
Biomedical subjects
Surena F Matin
Publications and source records attributed to Surena F Matin.
Laparoscopic approaches to urologic malignancies.
Urologic laparoscopy has had its greatest impact on patients with genitourinary malignancies. Only pelvic lymph node dissection and the occasional nephrectomy were considered oncologically feasible early in the evolution of laparoscopic urology. Presently, multiple approaches are considered standard at centers of excellence and in the general community. Laparoscopic adrenalectomy and radical nephrectomy have gained overwhelming acceptance. Laparoscopic cytoreductive nephrectomy has been found to be feasible for select patients with metastatic renal cell carcinoma. Minimally invasive nephron-sparing approaches, such as cryoablation, radiofrequency ablation, and laparoscopic partial nephrectomy, continue to generate great interest, but follow-up remains limited. Early data with laparoscopic radical prostatectomy suggest excellent continence rates and equivalent oncologic results based on pathologic surrogates of cure. However, long-term data are still needed, in addition to validated information regarding return of erectile function and quality of life. Other novel therapies, such as laparoscopic radical cystectomy with urinary diversion and laparoscopic retroperitoneal lymph node dissection, hold great promise of benefiting patients with urologic malignancies.
Carcinoma, Renal Cell↗
Laparoscopic partial nephrectomy with suture repair of the pelvicaliceal system.
OBJECTIVES: Laparoscopic partial nephrectomy is emerging as a viable minimally invasive nephron-sparing option for select patients with an exophytic renal tumor. With increasing experience, we are applying laparoscopic partial nephrectomy to tumors invading more deeply into the renal parenchyma, necessitating intentional caliceal entry to ensure an adequate margin of resection. In this prospective study, we assessed the safety and efficacy of such substantive renal parenchymal resections that incorporate laparoscopic suture repair of the collecting system. METHODS: Since August 1999, laparoscopic partial nephrectomy was performed in 64 patients with a renal tumor. Our technique routinely involved transient clamping of the renal artery and vein, caliceal suture repair (if necessary), and renal parenchymal suture repair. Intraoperative and postoperative data from the group requiring caliceal repair (group 1, n = 27) were compared with those not requiring caliceal repair (group 2, n = 37). The mean tumor size was 3.4 +/- 1.6 cm in group 1 and 2.6 +/- 0.9 cm in group 2 (P = 0.02). The mean depth of tumor invasion into the renal parenchyma was 1.5 +/- 0.8 cm in group 1 and 0.9 +/- 0.3 cm in group 2 (P = 0.15). RESULTS: Laparoscopic partial nephrectomy was technically successful in all 64 cases without any open conversions. Both groups 1 and 2 were comparable in terms of total operative time (3.2 +/- 0.9 hours versus 2.7 +/- 1.0 hours, P = 0.06), tumor excision time (5.9 +/- 1.8 minutes versus 6.0 +/- 1.9 minutes, P = 0.97), and estimated blood loss (241 +/- 306 mL versus 258 +/- 342 mL, P = 0.27). Pelvicaliceal suture repair was associated with a longer warm ischemia time (30.2 +/- 5.4 minutes versus 19.4 +/- 4.9 minutes, P <0.0001), and a greater hospital stay (3.0 +/- 1.7 days versus 1.8 +/- 1.2 days, P = 0.003). No patients in group 1, and 1 patient in group 2, developed an asymptomatic perinephric urinoma that was drained percutaneously. On pathologic examination, inked surgical margins were negative for cancer in all but 1 case; the width of the parenchymal margin on histologic examination was 0.5 +/- 0.4 cm in group 1, and 0.4 +/- 0.3 cm in group 2 (P = 0.59). The mean preoperative and postoperative serum creatinine was 1.1 and 1.2 mg/dL in group 1 and 1.0 and 1.1 mg/dL in group 2, respectively (P = 0.4). During a mean follow-up of 9.5 +/- 3.5 months in group 1 and 15.7 +/- 4 months in group 2, no renal unit developed irreversible ischemic damage or local cancer recurrence. CONCLUSIONS: Laparoscopic partial nephrectomy can be performed safely and efficaciously for select invasive renal tumors with intrarenal extension, even up to the collecting system. Intentional caliceal entry in such cases can be effectively repaired in a watertight manner by laparoscopic freehand suturing, albeit with longer mean operative and warm ischemia times, without adverse renal functional sequelae.
Adult↗
Modified Pfannenstiel incision for intact specimen extraction after retroperitoneoscopic renal surgery.
OBJECTIVES: To describe a simple modification of the Pfannenstiel incision for performing intact specimen extraction during retroperitoneal laparoscopic radical nephrectomy. TECHNICAL CONSIDERATIONS: After retroperitoneal laparoscopic radical nephrectomy is completed, and the specimen is entrapped in a specimen retrieval bag, a 5 to 7-cm Pfannenstiel (transverse) skin incision is made over the symphysis pubis, lateralized slightly toward the side of surgery. A vertical incision is then made in the anterior rectus fascia near the lateral aspect of the ipsilateral rectus muscle, from the level of the pubic bone extending cephalad for approximately 5 to 7 cm. The transversalis fascia is then perforated near the level of the pubis to enter the pelvic extraperitoneal space, which is developed to the upper retroperitoneum. The drawstring of the closed bag is grasped, allowing delivery of the entrapped intact specimen through the modified Pfannenstiel incision. CONCLUSIONS: More than 50 specimen extractions have been performed in this manner, with specimen weights ranging up to 1.7 kg, after retroperitoneoscopic radical nephrectomy. No complications specific to this incision and no postoperative hernias have developed, although follow-up was short. Our modification combines the advantage of a potentially less painful, non-muscle-cutting Pfannenstiel skin incision with the advantages of retroperitoneal access afforded by a Gibson fascial incision. Although it has been our initial subjective impression that the degree of comfort and cosmesis from this modified Pfannenstiel incision may be better than that after enlargement of the primary port site, a detailed comparison of these two approaches is required.
Abdominal Muscles↗
Prospective randomized trial of skin adhesive versus sutures for closure of 217 laparoscopic port-site incisions.
BACKGROUND: The purpose of this study is to determine whether closure of laparoscopic port-site incisions using octylcyanoacrylate (OCA) is feasible, whether it is faster than traditional subcuticular suturing, whether the number and length of incisions impact on closure time, and to determine wound morbidity and patient satisfaction outcomes. STUDY DESIGN: A prospective randomized trial was performed on adult patients scheduled for elective laparoscopic surgery in three surgical specialties at a tertiary referral center. Patients were randomized to have closure of laparoscopic port sites using either OCA or sutures. Patients were followed up 2 to 3 weeks postoperatively. At 2 months patients were mailed a questionnaire regarding their satisfaction with the method of closure and the appearance of their scars. RESULTS: A total of 175 incisions in 50 patients were closed with OCA, and 142 incisions in 42 patients were closed with subcuticular sutures. Time to close was significantly faster for OCA (median 2.5 minutes versus 6 minutes, p < 0.001). OCA was faster than traditional subcuticular suturing for cases involving three or more port sites (median 2.5 minutes versus 6 minutes, p < 0.001), and for cases with total length of incisions >4 cm (median 2.6 minutes versus 7 minutes, p < 0.001). OCA and subcuticular suturing groups did not differ significantly on patient acceptance or assessment of scars. CONCLUSIONS: Closure of laparoscopic port-site incisions is feasible with OCA. Closure with OCA requires significantly less operative time than subcuticular suturing, particularly in cases when three or more port sites are used or when total incision length is greater than 4 cm. OCA appears to have equivalent adverse wound outcomes and patient acceptance rates as subcuticular suturing.
Cost Savings↗
Ureteral tissue balloon expansion for laparoscopic bladder augmentation: survival study.
BACKGROUND AND PURPOSE: The search for the perfect urinary bladder substitute continues. Despite their inherent limitations, intestinal segments remain the commonest material for bladder reconstruction. The ureter, with its transitional epithelium, may be the ideal tissue to augment the bladder. Ikeguchi et al reported the feasibility of chronic ureteral balloon expansion by open surgery (J Urol 1998;159:1665). Herein, we propose a completely minimally invasive approach to balloon overdilate a segment of juxtavesical ureter incrementally and to use this in-line tissue-expanded ureteral patch to augment the bladder laparoscopically. MATERIALS AND METHODS: In five female pigs, a novel ureteral expansion balloon device (Microvasive, MA) was inserted percutaneously and advanced antegrade into the juxtavesical ureter. The device has two channels: one for balloon inflation and the other for draining the kidney. After progressive ureteral expansion over a 3- to 4-week period, laparoscopic augmentation ureterocystoplasty was performed. Animals were euthanized at 15 days (N = 1), 1 month (N = 1), 2 months (N = 1), and 3 months (N = 2). RESULTS: Percutaneous balloon device placement was technically successful in all five cases (mean operating room time 52 minutes). The mean volume of the tissue-expanded ureter at 1, 2, and 3 weeks was 12.9 cc, 60.3 cc, and 171.8 cc, respectively. Laparoscopic augmentation ureterocystoplasty with (N = 3) or without (N = 2) concomitant subtotal cystectomy was technically successful in all five cases without any open conversion. The mean operative time was 126.5 minutes, and the mean blood loss was 29 mL. Postoperative complications consisted of one case each of pyelonephritis and ureteral stricture. At autopsy, the mean capacity of the bladder was 574 mL, and the P(ves) at maximum capacity was 14 cm H(2)O. Histologic examination of the tissue-expanded ureter revealed regenerated transitional epithelium and muscle hypertrophy. CONCLUSIONS: Chronic ureteral tissue expansion can be carried out safely and efficaciously. The expanded tissue is thick, healthy, and vascular, with histologic features of normal transitional epithelium and muscle hypertrophy and hyperplasia. This expanded ureteral tissue can be used to augment the bladder with laparoscopic techniques. Such augmented bladders do not show significant shrinkage and possess urodynamic characteristic of normal capacity and normal compliance over a follow-up of 3 months.
Anastomosis, Surgical↗
Ureteroscopic laser endopyelotomy: a single-center experience.
PURPOSE: We review our experience with ureteroscopic endopyelotomy using a holmium laser for correction of ureteropelvic junction (UPJ) obstruction in order to further define the immediate and long-term results and complications. PATIENTS AND METHODS: From 1999 to 2002, 11 men and 34 women (mean age 42 years) underwent 46 ureteroscopic holmium laser endopyelotomy procedures for treatment of primary (N=40) or secondary (N=5) UPJ obstruction. The inclusion criteria were a short (<2-cm) obstruction and absence of ipsilateral renal calculi. Demographic, intraoperative, and postoperative measures were obtained from a prospectively designed and updated database. The endopyelotomy was performed under direct vision using a semirigid (N=40) or flexible (N=5) ureteroscope with a laser setting of 1 J at 10 Hz. Radiographic confirmation of obstruction and the results of intervention was obtained by combinations of intravenous and diuretic urography, diuretic renography, ultrasonography, and CT. The first postoperative and latest radiographic follow-up studies were compared with the preoperative studies to determine whether the obstruction was resolved, unchanged, or worsened. Success was defined as symptomatic relief and radiographic resolution. RESULTS: The mean operative time was 65 minutes (range 10-153 minutes). There were no intraoperative complications, although 5 patients (11.1%) experienced postoperative complications consisting of subcapsular hematoma, pyelonephritis, sepsis, urinary retention, or dysrhythmia. Forty-two patients (93%) had a hospital stay of <23 hours. Stents were removed 3 to 8 weeks (mean 5 weeks) postoperatively. The mean length of follow-up was 23.2 months (range 5-43 months). Symptoms were resolved in 65.4% of patients, improved in 7.7%, unchanged in 11.5%, and worse in 15.4%. Radiographically, at latest follow-up, the obstruction was resolved in 73.1% of patients, unchanged in 23.1%, and worse in 3.8%. Primary UPJ obstruction was associated with a symptomatic success rate of 68% compared with only 50% for secondary UPJ obstruction. CONCLUSIONS: Ureteroscopic laser endopyelotomy is a minimally invasive, short-stay outpatient procedure associated with a 65.4% symptomatic and 73.1% radiographic success rate. In contrast to the findings in previous reports of results of retrograde or antegrade endopyelotomy, patients treated for primary UPJ obstruction experienced higher rates of success than those with secondary obstruction.
Adolescent↗
Laparoscopic radical nephrectomy for cancer with level I renal vein involvement.
PURPOSE: Venous involvement develops in 5% to 10% of patients with renal cell carcinoma and is generally considered a relative contraindication to laparoscopic radical nephrectomy. To our knowledge we report the initial clinical series of laparoscopic radical nephrectomy for renal cell carcinoma associated with level I renal vein thrombus. MATERIALS AND METHODS: At our 2 institutions 8 patients each underwent laparoscopic radical nephrectomy for level I microscopic renal vein thrombus (group 1) and level I gross thrombus (group 2). In all 8 group 2 patients the level I thrombus was preoperatively diagnosed by computerized tomography. Mean renal tumor size in groups 1 and 2 was 7.8 and 12.4 cm., respectively. After controlling the renal artery the renal vein was secured by firing an endoscopic gastrointestinal anastomosis stapler on its collapsed, uninvolved proximal part adjacent to the vena cava. Intraoperative, postoperative and pathological parameters were assessed in the 2 groups. RESULTS: In group 1 laparoscopic radical nephrectomy was technically successful in all 8 patients. Mean operative time was 3.1 hours, mean estimated blood loss was 382 cc and mean hospital stay was 1.9 days. In 1 patient each a soft tissue and a vascular margin was positive for cancer. At a mean follow up of 19.5 months (range 2 to 36) metastatic disease occurred in 3 cases (38%). In group 2 laparoscopic radical nephrectomy was technically successful in 7 cases with open conversion in 1. Mean operative time was 3.3 hours, mean estimated blood loss was 354 cc and mean hospital stay was 2.3 days. Surgical soft tissue and the renal vein vascular margin of the transected vein were negative for cancer in all 8 cases. At a mean followup of 9.4 months (range 5 to 16) pulmonary metastasis developed in 1 patient (13%). CONCLUSIONS: Although it is an advanced procedure, laparoscopic radical nephrectomy in patients with level I renal vein thrombus is feasible, safe and follows established oncological principles.
Adult↗
Comparative analysis of laparoscopic versus open partial nephrectomy for renal tumors in 200 patients.
PURPOSE: Laparoscopic partial nephrectomy is an emerging minimally invasive, nephron sparing approach for renal cell carcinoma. We compared perioperative outcomes after laparoscopic and open nephron sparing surgery (NSS) for patients with a solitary renal tumor of 7 cm or less at a single institution. MATERIALS AND METHODS: Since September 1999, 100 consecutive patients have undergone laparoscopic partial nephrectomy for a sporadic single renal tumor of 7 cm or less at our institution. A contemporary cohort of 100 consecutive patients with similar inclusion criteria have undergone open NSS since April 1998. Since our laparoscopic technique was based on our established open surgical principles, the 2 approaches were similar, including transient renal vascular control, sharp tumor excision in a bloodless field, pelvicaliceal repair when necessary, suture ligation of transected intrarenal blood vessels and suture repair of the renal parenchymal defect over a bolster. Demographic, intraoperative, postoperative and short-term followup data were retrospectively compared between the 2 groups. RESULTS: Median tumor size was 2.8 cm in the laparoscopic group and 3.3 cm in the open group (p = 0.005). There were significantly more tumors greater than 4 cm in the open group (p <0.001). There were more patients with a solitary kidney in the open surgical group (p = 0.002). More patients in the open group underwent NSS for a malignant tumor (p = 002). Comparing the laparoscopic versus open groups, median surgical time was 3 vs 3.9 hours (p <0.001), blood loss was 125 vs 250 ml (p <0.001) and mean warm ischemia time was 27.8 vs 17.5 minutes (p <0.001), respectively. In the laparoscopic and open groups median analgesic requirement was 20.2 vs 252.5 mg morphine sulfate equivalents (p <0.001), hospital stay was 2 vs 5 days (p <0.001) and average convalescence was 4 vs 6 weeks (p <0.001). Median preoperative serum creatinine (1.0 vs 1.0 mg/dl, p = 0.52) and postoperative serum creatinine (1.1 vs 1.2 mg/dl, p = 0.65) were similar in the 2 groups. No kidney was lost due to warm ischemic injury. Three patients in the laparoscopic group had a positive surgical margin compared to none in the open groups (3% vs 0%, p = 0.1). Laparoscopic NSS was associated with a higher rate of major intraoperative complications (5% vs 0%, p = 0.02). There were no significant differences in overall postoperative complications, although renal/urological complications were more common in the laparoscopic group (11% vs 2%, p = 0.01). CONCLUSIONS: Open surgical partial nephrectomy remains the established standard for nephron sparing treatment of renal tumors. When applied to small renal tumors, the laparoscopic approach is associated with longer warm renal ischemia time, more major intraoperative complications and more postoperative urological complications. Our data also suggest that more deliberate efforts to achieve a wider surgical margin are necessary with the laparoscopic approach. Nevertheless, our data suggest that laparoscopic NSS is emerging as an effective, minimally invasive therapeutic approach with respect to renal functional outcome with the additional advantages of decreased postoperative narcotic use, earlier hospital discharge and a more rapid convalescence. Continued efforts are required to develop laparoscopic renal hypothermia techniques and facilitate intrarenal suturing, while minimizing warm ischemia time.
Aged↗
Evaluation of age and comorbidity as risk factors after laparoscopic urological surgery.
PURPOSE: Few reports in the urological literature have focused on the growing population of elderly (65 years or older) patients. Coexistent medical conditions, which are more prevalent in elderly individuals, can confound results of outcome studies in this population. This single center, retrospective study was done to determine whether age and comorbidity are predictors of outcome in patients undergoing laparoscopic renal and adrenal surgery. MATERIALS AND METHODS: From 1997 to 2001 laparoscopic radical nephrectomy, partial nephrectomy, nephroureterectomy and adrenalectomy were performed in 399 consecutive adults. Patient demographics and preoperative, intraoperative and postoperative parameters were extracted from a prospectively designed computerized database. Risk stratification was based on preoperative American Society of Anesthesiologists (ASA) score. Additional risk stratification was constructed using the Charlson comorbidity index. Univariate and multivariate analyses were also performed. RESULTS: Age 65 years or older was not associated with an increased incidence of intraoperative, postoperative or late operative complications on univariate or multivariate analyses. However, patients 65 years or older were hospitalized significantly longer than those younger than 65 years (43 vs 24 hours, p = 0.02). Blood loss and the requirement for blood transfusion were associated with longer operative time, a higher incidence of intraoperative and postoperative complications on univariate analysis, and longer hospitalization. No association of blood loss with postoperative complications was noted on multivariate analysis. Patients with a higher ASA score were more likely to receive blood transfusion. On univariate analysis risk stratification using the ASA score and the Charlson comorbidity index was not associated with intraoperative or postoperative complications. However, on multivariable analysis patients with the lowest indexes were less likely to experience postoperative complications than those with the highest indexes (less than vs greater than 3, p = 0.04). The comorbidity index had a marginal association with the incidence of late complications (p = 0.06). CONCLUSIONS: Laparoscopic renal and adrenal surgery in patients 65 years or older is well tolerated. Age 65 years or older is predictive of a significantly increased hospital stay of approximately 1 day after major renal and adrenal laparoscopic surgery and it does not appear to increase independently the risk of intraoperative, postoperative or late operative complications.
Age Factors↗
Laparoscopic radical nephrectomy: retroperitoneal versus transperitoneal approach.
Laparoscopic radical nephrectomy can be efficaciously performed by either the transperitoneal or the retroperitoneal laparoscopic approach. The primary indication for selecting one approach over another has historically depended on the individual surgeon's experience and training. With either technique, laparoscopy adheres to established surgical oncologic principles of wide specimen mobilization and early vascular control. This article reviews the history, contraindications, anatomic considerations, patient preparation, and surgical technique of these two laparoscopic approaches. A salient summary of the worldwide experience with these procedures is presented, as well as a brief synopsis of controversial arguments favoring specimen morcellation versus intact extraction.
Humans↗
Acute renal failure due to subcapsular renal hematoma in a solitary kidney: improvement after decompression.
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Acute Kidney Injury↗
Outcome of laparoscopic radical and open partial nephrectomy for the sporadic 4 cm. or less renal tumor with a normal contralateral kidney.
PURPOSE: Nephron sparing surgery provides effective therapy in patients with a solitary sporadic renal tumor 4 cm. or less and a normal contralateral kidney. Laparoscopic radical nephrectomy has been applied as a newer alternative therapy in these patients. These 2 contemporary approaches represent divergent treatment alternatives at centers where laparoscopic nephron sparing surgery is not offered. We compared the short-term and long-term impact of these 2 treatment modalities in patients with a sporadic localized solitary renal tumor 4 cm. or less and a normal opposite kidney. MATERIALS AND METHODS: A retrospective review of a contemporary series of patients (1996 to 2001) who underwent open nephron sparing surgery and met study inclusion criteria was performed and compared with a similar cohort (1997 to 2001) that underwent laparoscopic radical nephrectomy. Only patients with a single renal tumor of 4 cm. or less, normal serum creatinine less than 1.5 mg./dl. and a normal contralateral kidney were included in analysis. The 2 groups were compared in regard to demographic, clinical and pathological variables using parametric and nonparametric tests. Linear regression analysis was done to compare the percent change in serum creatinine, while adjusting for demographic and clinical variables, and followup. RESULTS: A total of 35 patients who underwent laparoscopic radical nephrectomy and 82 who underwent open nephron sparing surgery met study inclusion criteria. Mean patient age in the laparoscopic group was significantly greater (67.3 versus 56.2 years, p <0.001), mean American Society of Anesthesiologists class score was higher (p = 0.04) and mean tumor size was greater (3.1 versus 2.6 cm., p = 0.003) than in the nephron sparing group. The laparoscopic group had significantly decreased mean blood loss (100 versus 200 ml., p <0.001), hospital stay (1 versus 5 days, p <0.001), narcotic use (16.5 versus 224 mg., p <0.001) and operative time (184.4 versus 216.2 minutes, p <0.007) compared with the nephron sparing group. Patients who underwent nephron sparing surgery experienced less postoperative deterioration in renal function, as measured by the percent increase in serum creatinine postoperatively (0% versus 25%, p <0.001). The results of regression analyses at 4 and 6 months of followup indicated that open nephron sparing surgery is associated with significantly lower serum creatinine than laparoscopic radical nephrectomy after adjusting for demographic and clinical variables, and followup. CONCLUSIONS: Open nephron sparing surgery and laparoscopic radical nephrectomy are relatively recent and significant developments for treating patients with renal cell carcinoma and they represent accepted standards of care in those with a small renal mass and normal contralateral kidney. In patients presenting with a sporadic solitary renal tumor of 4 cm. or less and a normal contralateral kidney the significant short-term and intermediate term benefits of the laparoscopic approach must be weighed against the long-term advantage of better renal function associated with open nephron sparing surgery. The distinct advantages of these 2 approaches may ultimately be realized with the standardization of laparoscopic partial nephrectomy.
Aged↗
Robotic-assisted laparoscopic adrenalectomy.
INTRODUCTION: Remote robotic telemanipulators have been recently used in performing laparoscopic urologic procedures, both in the laboratory and in clinical practice. We present, to our knowledge, the initial 2 cases of robotic-assisted laparoscopic adrenalectomy in humans. TECHNICAL CONSIDERATIONS: Robotic-assisted laparoscopic adrenalectomy (one right, one left) was performed in 2 patients with an adrenal tumor (one nonfunctional, one pheochromocytoma). Patient age was 81 and 47 years, and tumor size was 4.5 and 3 cm, respectively. Both cases were performed transperitoneally using the da Vinci Robotic Surgical System. Robotic-assisted laparoscopic adrenalectomy was successful in both cases without conversion to conventional laparoscopy or open surgery. The operative time was 110 and 165 minutes, the blood loss was 50 and 100 mL, and the hospital stay was 2 and 3 days. No intraoperative or postoperative complications occurred. CONCLUSIONS: Robotic-assisted laparoscopic adrenalectomy is technically feasible. With increasing experience and refinement in the technology, the role of robotics in urologic laparoscopy is likely to expand.
Adrenal Gland Neoplasms↗
Laparoscopic radical cystectomy with urinary diversion: completely intracorporeal technique.
Laparoscopic radical cystectomy with urinary diversion performed using intracorporeal techniques exclusively is a new development in the growing field of minimally invasive urology. This report details step by step the completely intracorporeal laparoscopic technique of cystectomy, bilateral pelvic lymphadenectomy, and urinary diversion with creation of an ileal conduit or neobladder, including the isolation of ileum, restoration of bowel continuity, retroperitoneal transfer of the left ureter to the right side, bilateral stented ureteroileal anastomoses, and urethroileal anastomosis in case of orthotopic diversion. Although at present, this is still a technique in development at high-volume medical centers, it holds promise as a minimally invasive yet appropriately radical form of treatment for patients with muscle-invasive bladder cancer. Definition of its true role awaits greater experience and long-term comparisons of the outcomes with those of traditional open surgery.
Cystectomy↗