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Biomedical subjects

Susan Hart

Publications and source records attributed to Susan Hart.

4 recordsLinked to original sources
PubMed2005

Fluid Intake in patients with eating disorders.

OBJECTIVES: The current study examined the fluid intake of patients with eating disorders and factors that may influence the amount and type of fluid consumed. Subjects comprised 81 inpatients with eating disorders. METHODS: A 7-day semi-standardized, retrospective fluid history was taken by a dietitian when the subjects were admitted to an eating disorder unit. Total fluid consumed per day was measured, which included all energy-free, energy-containing, and caffeine-containing fluids (all in milliliters per kilogram). Age, body mass index (BMI), and eating disorder behaviors (purging, binge eating, and excessive exercise) were also evaluated. RESULTS: Fluid intakes ranged from 250 ml to >6 L per day, with an average of 2.7 L. Only 17% of patients had fluid intakes in the recommended range. The most commonly consumed beverage was water followed by diet cola, coffee, juice, and tea. The lower the BMI and the older the patient, the greater the fluid intake. CONCLUSIONS: Fluid intake is variable and should be part of the clinical assessment of the eating disorder patient.

Adolescent↗
PubMed2004

Phase II study of proteasome inhibitor bortezomib in relapsed or refractory B-cell non-Hodgkin's lymphoma.

PURPOSE: Evaluate efficacy and toxicity of bortezomib in patients with relapsed or refractory B-cell non-Hodgkin's lymphoma. PATIENTS AND METHODS: Patients were stratified, based on preclinical data, into arm A (mantle-cell lymphoma) or arm B (other B-cell lymphomas) without limitation in number of prior therapies. Bortezomib was administered as an intravenous push (1.5 mg/m2) on days 1, 4, 8, and 11 every 21 days for a maximum of six cycles. RESULTS: Sixty patients with a median number of prior therapies of 3.5 (range, one to 12 therapies) were enrolled; 33 patients were in arm A and 27 were in arm B, including 12 diffuse large B-cell lymphomas, five follicular lymphomas (FL), three transformed FLs, four small lymphocytic lymphomas (SLL), two Waldenstrom's macroglobulinemias (WM), and one marginal zone lymphoma. In arm A, 12 of 29 assessable patients responded (six complete responses [CR] and six partial responses [PR]) for an overall response rate (ORR) of 41% (95% CI, 24% to 61%), and a median time to progression not reached yet, with a median follow-up of 9.3 months (range, 1.7 to 24 months). In arm B, four of 21 assessable patients responded (one SLL patient had a CR, one FL patient had a CR unconfirmed, one diffuse large B-cell lymphoma patient had a PR, and one WM patient had a PR) for an ORR of 19% (95% CI, 5% to 42%). Grade 3 toxicity included thrombocytopenia (47%), gastrointestinal (20%), fatigue (13%), neutropenia (10%), and peripheral neuropathy (5%). Grade 4 toxicity occurred in nine patients (15%), and three deaths from progression of disease occurred within 30 days of withdrawal from study. CONCLUSION: Bortezomib showed promising activity in relapsed mantle-cell lymphoma and encouraging results in other B-cell lymphomas. Future studies will explore bortezomib in combination with other cytotoxic or biologic agents.

Adult↗
PubMed2002

Effects of standing and sitting on finger-tapping speed in healthy adults.

STUDY DESIGN: A repeated-measures design was used to compare finger-tapping performance (hand functional control) across 4 standing and sitting conditions of limb body support postures. OBJECTIVES: The intent was to examine the hypothesized hemispheric control interference effects of lower limb body support postures on finger-tapping performance. A secondary objective was to gain a better understanding of the relationship between lower limb posture and concurrent finger-tapping activity. BACKGROUND: In a task such as kicking a ball with the right foot, foot control theory suggests that the left hemisphere contralaterally controls right-foot kicking action. However, it can also be interpreted that the postural support (with the left foot in this example) involving the action of antigravity muscles (leg extensors) is driven ipsilaterally. Based on this explanation, we would expect a hemispheric effect to occur during standing on the left limb while performing a finger-tapping task with the right hand. This study has theoretical and clinical significance for understanding hemispheric and functional control of limbs, which may underlie the assessment of movement control and the development and use of therapeutic interventions that can potentially improve functional movement control. METHODS AND MEASURES: Ninety-eight (98) adult participants (ages 19 to 32 years) performed a finger-tapping task in 4 postural conditions: seated, standing on both feet, standing on the right foot only (RF), and standing on the left foot only (LF). RESULTS: As predicted, manual performance was significantly slower in the LF condition as compared to the standing and sitting positions. However, when comparing performance between the LF and RF conditions, the difference was minimal. CONCLUSIONS: Although support for the ipsilateral effect was not found, postural position did influence manual performance.

Adult↗