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Biomedical subjects

Susan M Cera

Publications and source records attributed to Susan M Cera.

5 recordsLinked to original sources

Laparoscopic surgery for ulcerative colitis.

Laparoscopic techniques have revolutionized management of colorectal diseases; however, inflammatory diseases of the intestine have proven challenging because of the technical demands of their nature. Intense investigation and subsequent refinements in technique and technology have recently led to considerable advances and a clear role for laparoscopic management of Crohn's disease. and diverticulitis; laparoscopy for ulcerative colitis has not proven as promising. Laparoscopic procedures for ulcerative colitis require a significant learning curve. Although numerous experienced laparoscopic teams have documented their ability to complete them, long operative times and elevated rates of morbidity in some studies appear to counter the advantages. The question remains as to the universal application and appropriateness of these procedures in surgical management of ulcerative colitis.

Colectomy↗

Physiologic predictors of survival in post-traumatic arrest.

Traumatic cardiac or pulmonary arrest is often associated with a dismal outcome and is considered by many to be an example of medical futility and inappropriate use of resources. This study aimed to identify the predictors of survival in patients experiencing traumatic cardiac arrest. We retrospectively reviewed all trauma patients undergoing cardiopulmonary resuscitation on arrival to the Emergency Department (ED) at an American College of Surgeons-designated Level I trauma center over 4 years. ED survival, hospital survival, and neurologic outcomes on discharge were the primary outcomes. Survival rates were examined in relation to demographics, mechanism of injury, airway management, cardiac electrical rhythm, and pupil size and reactivity. Statistical analyses used chi-square and t tests, P < 0.05 was considered significant. A total of 195 patients arrived in the ED with traumatic cardiac arrest; 34 were pronounced dead on arrival (no signs of life), and no resuscitation efforts were initiated. Of the remaining 161 patients 53 (33%) survived to leave the ED, and only 15 (9%) left the hospital alive. Demographic features were similar in survivors and nonsurvivors. The setting of intubation (prehospital vs ED) did not influence survival (P = 0.36). Penetrating trauma adversely affected survival in the ED (P = 0.01); however, this only approached significance in the final outcome of hospital survival (P = 0.06). The presence of sinus rhythm and nondilated reactive pupils was highly significant in predicting ED and hospital survival (P = 0.001). No patient with agonal rhythm or ventricular fibrillation/tachycardia survived, and 14 of the 15 hospital survivors had reactive pupils on arrival to the ED. We conclude that sinus rhythm and pupil size and reactivity are important physiologic variables that predict potential survival and may be used to guide continuation of resuscitative efforts in patients with traumatic cardiac arrest.

Adolescent↗

Minimally invasive treatment of colon cancer.

The advantages of laparoscopy in the treatment of benign diseases have been well demonstrated. Compared with laparotomy, the laparoscopic approach is associated with a shorter hospitalization period, shorter duration of ileus, decreased postoperative pain, earlier return to work, and improved cosmesis. The role of laparoscopy for the treatment of gastrointestinal malignancy has had a slower evolution and been the subject of considerable debate over the past decade. Since 1991, several concerns have limited the widespread use of laparoscopy for attempted cure of colorectal carcinoma. This review aims to analyze the results of several studies published to date on short and long term outcome of laparoscopy for colorectal carcinoma, based on levels of evidence. From the least to the most convincing data, the hierarchy of study designs progresses through a spectrum ranging from retrospective reviews to prospective series, to case-controlled, cohort, and ultimately randomized controlled trials.

Carcinoma↗