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Susana Holgado

Publications and source records attributed to Susana Holgado.

5 recordsLinked to original sources
PubMed2006

Piezoelectric ultrathin lead titanate films prepared by deposition of aquo-diol solutions.

We report on the preparation of continuous ultrathin ferroelectric films of pure lead titanate by chemical solution deposition (CSD) methods. Aquo-diol solutions highly diluted have been used to obtain films with thickness down to approximately 13 nm, the lowest reported for CSD films. The formation of islands instead of continuous coatings, which has been reported when CSD is used to prepare ultrathin films, is avoided here. The piezoelectric activity of the films has been characterized by piezoresponse. force microscopy, showing that the thinnest film obtained retains a significant piezoelectric activity at the nanoscale, which is promising for their use as transducer elements in nanoelectromechanical systems (NEMS).

Crystallization↗
PubMed2005

Reversal of HIV-1-associated osteoporosis with once-weekly alendronate.

HIV-1-infected patients with osteoporosis were randomly assigned to alendronate 70 mg once-weekly plus dietary counselling (n = 11) or diet counselling alone (n = 14). At week 96, 27% of patients on alendronate versus 96% of controls presented with osteoporosis. Spine bone mineral density (BMD) increases were detected at week 48, and progressed thereafter. Improvements in trochanter BMD were obtained after 2 years. Once-weekly oral alendronate may be an effective and safe treatment for HIV-1-associated osteoporosis.

Alendronate↗
PubMed2002

[Paget's disease of bone: study of 314 patients].

BACKGROUND: To describe the clinical and laboratory features of Paget's disease of bone at the time of diagnosis. PATIENTS AND METHOD: This multicenter and retrospective study included 314 patients. Diagnosis was performed by means of characteristic radiological findings and typical bone scintigraphy. The variables analyzed included: epidemiological variables, cause of diagnosis, bone involvement, disease extension (Coutris index), complications, alkaline phosphate (AP) levels and disease activity (Renier index). RESULTS: There were 159 (50.5%) males and the mean age was 64.9 years (SD 12.6). Diagnosis was casual in 228 (72.6%) patients. Polyostotic involvement was detected in 201 (63.9%) patients. More common locations were pelvis, skull and lumbar spine. Sacrum was more frequently involved in men than in women (p < 0.05), whereas skull involvement was more common in women (p < 0.05). The number of bones involved was 3.1 SD 3 and the percentage of skeletal involvement was 8.7 % (SD 6.5). One hundred ninety eigth (63%) patients had complications. The disease was active in 242 (77%) patients with a mean AP value of 377 IU/L (SD 493); the activity of the disease measured by the Renier index was 34 (SD 46); the activity was greater in the skull and the humerus. CONCLUSIONS: Paget's disease of bone is usually asymptomatic. Polyostotic involvement and activity are common at the time of diagnosis. Knowledge of the extension and activity by means of a mathematical model may aid to make therapeutical decisions.

Adult↗