Biomedical subjects

Susanne Müller-Egloff

Publications and source records attributed to Susanne Müller-Egloff.

4 recordsLinked to original sources

PubMed2005

Does chronic prenatal Doppler pathology predict feeding difficulties in neonates?

AIM: To determine whether infants with compromised fetomaternal circulation, but not yet critically threatened by absent end-diastolic flow velocities in the umbilical arteries, are at a risk for feeding problems. METHODS: In a retrospective case-control study, enteral feeding and clinical data were compared between infants with decreased prenatal end-diastolic umbilical flow velocity (DEDFV) or brain-sparing pathology and controls matched for gestational age (GA). In all infants, enteral feedings were advanced according to a standardized enteral feeding protocol. RESULTS: 11 (GA>34 wk) of the 87 infants with DEDFV were fully enterally fed by day 5 and excluded, leaving 76 infants (and matched controls) for final analysis. DEDFV infants were significantly smaller (1,230+/-550 g vs 1,600+/-682 g). Advancement of enteral feedings varied widely, with a significant difference between DEDFV infants and controls. There was no difference in the incidence of NEC (five in both groups). In the most severely affected subgroup of 25 infants with GA<30 wk and prenatal brain sparing, enteral feedings were significantly delayed in comparison to the controls (parenteral amino acid administration for 22 vs 15 d; significantly fewer enteral calories through day 15). CONCLUSION: Enteral feeds were introduced more slowly to infants who had shown signs of prenatal distress with brain sparing. However, a predisposition to NEC could not be proven. Our results thus do not support the delay of enteral feedings based on prenatal Doppler pathology.

Blood Flow Velocity↗

PubMed2003

[Cervical incompetence in multifetal gestation: diagnosis and prophylaxis].

OBJECTIVE: Preterm birth following cervical incompetence threatens infants of multiple gestation. The questions at hand are whether we can validate a sonographic early detection system and if prophylactically intended strategies, such as cervical cerclage, potentially influence pregnancy management and/or perinatal outcome. METHODS: Multifetal pregnancies surveyed with three-dimensional ultrasound and pregnancies treated with cervical cerclage were compared to controls. RESULTS: Volumetry of the cervix was possible in all 34 examinations performed. In contrast, two-dimensional cervical length assessment could not be obtained in 6% because the presenting fetal part obstructed the sonographic plane. Mean cervical length was 28.7 mm (SD 7.7). Mean cervical volume was 30.0 cm3 (SD 16.0). A significant correlation was found between mean two-dimensional cervical length and mean cervical volume as both parameters decreased with gestational age (p = 0.01). Prophylactic cervical cerclage was used in 17% of triplet pregnancies studied at a mean gestational age of 16 + 2 weeks (98-138 days). In 50% of the quadruplet/quintuplet pregnancies studied, the cerclage was performed at a mean gestational age of 15 + 2 weeks of gestation (78-152 days). The time interval from operation to delivery was 106 days (62-119) for triplets and 96 days (57-142) for quadruplets/quintuplets. Prophylactic cervical cerclage did not prolong pregnancies compared to controls. With respect to the need for hospitalization or intravenous tocolysis or perinatal outcome parameters, no benefit was achieved. CONCLUSIONS: The results disclaim a positive impact of prophylactic cervical cerclage on the course of a multifetal pregnancy and/or perinatal outcome. On the other hand, early non-invasive diagnosis of cervical incompetence enables a risk-adapted conservative pregnancy management.

Adult↗

PubMed2002

[Obstetrical ultrasonography].

BACKGROUND: As with all new diagnostic options in medicine, great hope was placed in the introduction of high-resolution prenatal sonography. Progress tends to induce higher expectations. Patients and doctors alike may initially overestimate the possibilities of medical advances. QUESTION: The question at hand is whether we can validate a positive influence of prenatal ultrasound on the fetal and/or maternal pregnancy outcome, and how a sonographic routine screening should be structured. MATERIAL AND METHODS: This is an attempt to survey the heterogeneous pool of internationally published data with regard to these critical questions. RESULTS AND CONCLUSION: Different studies lead to a positive conclusion on the benefits of ultrasound monitoring in pregnant women. Ultrasound screening has a positive effect on medical as well as economic issues. Nevertheless litigation concerning prenatal diagnosis remains a growing problem.

Congenital Abnormalities↗

PubMed2002

Routine cervical cerclage in higher order multiple gestation -- does it prolong the pregnancy?

Preterm birth following cervical dilatation is the greatest threat to infants of a multiple pregnancy. Lacking reliable data concerning the effect of prophylactic cerclage, we compared a study group to controls for maternal and perinatal outcome. Sixteen of 94 triplet-, 9 of 18 quadruplet/quintuplet-pregnancies, treated with prophylactic cerclage, were retrospectively compared to those without cervical cerclage respectively. Kruskal-Wallis test and Mann-Whitney-U test were performed as non-parametric one way analysis of variance. For the analysis of frequencies Chi Square test or Fisher's exact test were performed. Odds ratio with 95% confidence interval was used to compare the need for intravenous tocolysis as well as perinatal morbidity and mortality. Gestational age at delivery was not different from the controls in all studied groups. Birth weight revealed a 200 g dominance for the "no cerclage-triplets", while this significant difference was inverted for quadruplets/quintuplets (1245 g vs. 1069 g). With respect to gestational age at birth, need for hospitalisation or medical intervention no benefit was achieved. Moreover, perinatal outcome analysed by arterial pH, APGAR-Score and perinatal mortality was not altered by a prophylactic cerclage. Perinatal morbidity for quadruplets and quintuplets was even higher in cerclage pregnancies. Therefore, these retrospective results disclaim a positive impact of cervical cerclage on pregnancy management or perinatal outcome in multifetal pregnancies.

Apgar Score↗