Biomedical subjects

Susanne Striegler

Publications and source records attributed to Susanne Striegler.

3 recordsLinked to original sources

PubMed2005

A sugar's choice: coordination to a mononuclear or a dinuclear copper(II) complex?

We proposed a decisive role of the number of metal ions at the sugar binding site for carbohydrate-coordinating copper(II) complexes. To verify this hypothesis, we studied the binding of the representatively chosen carbohydrates D-ribose (7), D-mannose (8), D-glucose (9), and D-maltose (10) to structurally related mono- and dinuclear copper(II) complexes in alkaline solution. All carbohydrates coordinate to the metal complexes in a 1:1 molar ratio. Coordination of 7 or 8 to the dinuclear copper(II) complex 1 is about 0.5 order of magnitude stronger than the complex formation with related mononuclear complexes. On contrast, 9, which is an epimer of 8, coordinates stronger to either one of the mononuclear copper(II) complexes in alkaline aqueous solution.

Carbohydrates↗

PubMed2004

Designing selective sites in templated polymers utilizing coordinative bonds.

This review gives a survey over recent achievements on the design of selective sites in templated polymers. Particularly, coordinative bonds as driving force for the interaction between a substrate and a templated polymer are discussed. Recent achievements on the selective recognition of larger molecules, such as dipeptides and disaccharides, are highlighted that promise a fast development on biomolecule templated material towards enzyme-like catalysis in the up-coming years. Additionally, the achievements on the incorporation of catalytic centers based on transition metal complexes are summarized.

Amino Acids↗

PubMed2003

A sugar discriminating binuclear copper(II) complex.

We investigated the complex formation between various underivatized carbohydrates and the binuclear copper(II) complex 1, Cu(2)(bpdpo). A combined approach of UV/vis and CD spectroscopic investigations shows a large discrimination ability of 1 for structurally closely related monosaccharides in alkaline solution. The dominating form of the binuclear copper(II) complex consists of a [Cu(2)L(-)(H)(OH)(2)](+) species between pH 11 and 13, as determined from pH-dependent spectrophotometric titration experiments. The binding strengths of the 1:1 sugar-1 complexes, derived from the biologically important monosaccharides d-mannose (3) and d-glucose (5), is about 1.5 orders of magnitude different at pH 12.40. Moreover, a blue- or a red-shift of the absorption maximum of 1 accompanies the sugar binding and highlights the ability of 1 to discriminate carbohydrates. This phenomenon is due to the number of hydroxyl groups of the particular monosaccharide involved in chelation to the binuclear metal complex.

Carbohydrates↗